Navigation Links
Research targets basic metabolism of disease-causing fungi, bacteria
Date:8/18/2010

Pablo Sobrado, assistant professor of biochemistry with the Fralin Life Science Institute at Virginia Tech, has received a $1.1 million grant from the National Science Foundation (NSF) to advance his research on the mechanism of iron acquisition in fungi and mycobacteria.

Iron is essential for all life. The level of free iron in humans is less than Aspergillus fumigatus and Mycobacterium tuberculosis need. To satisfy their metabolic needs and enable infection, these microbes secrete molecules called siderophores to obtain iron from the host. The synthesis of siderophores requires special enzymes. Sobrado is studying these enzymes. "Our aim is to understand how the enzymes activate molecular oxygen and attach it to the substrate molecules, lysine or ornithine, in the biosynthesis of siderophores," he said.

He reported in the July 2010 issue of the journal Biochemistry that the enzyme from A. fumigatus contains the cofactor flavin adenine dinucleotide (FAD) that reacts with molecular oxygen and forms a stable intermediate. The NSF grant will fund the research to elucidate the mechanism of action and the structure of the enzymes from A. fumigatus and M. tuberculosis, specifically, how they stabilize the intermediate and what regulates the specificity of the enzyme.

The paper, "Aspergillus fumigatus SidA is a highly specific ornithine hydroxylase with bound flavin cofactor," by Wyatt Chocklett and Sobrado, is available at www.ncbi.nlm.nih.gov/pubmed/20614882.

For the educational component of the NSF grant, Sobrado is collaborating with a group at the University of Pavia who are experts on protein crystallography. "Our students will travel to Italy to be trained in how to solve the structure of enzymes," he said. "The goal is to train global scientists."

The students will include members of Virginia Tech's Multicultural Academic Opportunities Program and Post-baccalaureate Research and Education Program, as well as high school students who will present their work at the local science fair.


'/>"/>

Contact: Susan Trulove
strulove@vt.edu
540-231-5646
Virginia Tech
Source:Eurekalert  

Related biology news :

1. Wistar Institute researcher receives New Innovator award from NIH
2. NC State researchers get to root of parasite genome
3. White Mountain Research Station to host climate change conference
4. Stevens awarded $1M for advanced biofuels research
5. Researchers find animal with ability to survive climate change
6. Researchers find an essential gene for forming ears of corn
7. Researchers note differences between people and animals on calorie restriction
8. Researcher working on destruction of chemical weapons
9. Researchers study acoustic communication in deep-sea fish
10. Researchers discover that growing up too fast may mean dying young in honey bees
11. The Rett Syndrome Research Trust launches operations
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Research targets basic metabolism of disease-causing fungi, bacteria
(Date:6/9/2016)... 9, 2016 Paris Police ... video security solution to ensure the safety of people and ... during the major tournament Teleste, an international technology ... services, announced today that its video security solution will be ... back up public safety across the country. The system roll-out ...
(Date:6/2/2016)... Perimeter Surveillance & Detection Systems, ... Infrastructure, Support & Other Service  The latest ... comprehensive analysis of the global Border Security market ... of $17.98 billion in 2016. Now: In ... in software and hardware technologies for advanced video surveillance. ...
(Date:5/12/2016)... DALLAS , May 12, 2016 ... has just published the overview results from the Q1 ... of the recent wave was consumers, receptivity to a ... wearables data with a health insurance company. ... choose to share," says Michael LaColla , CEO ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... ... June 23, 2016 , ... Charm Sciences, Inc. is pleased ... received AOAC Research Institute approval 061601. , “This is another AOAC-RI approval of ... Salter, Vice President of Regulatory and Industrial Affairs. “The Peel Plate methods perform ...
(Date:6/23/2016)...   EpiBiome , a precision microbiome engineering company, ... financing from Silicon Valley Bank (SVB). The financing will ... its drug development efforts, as well as purchase additional ... has been an incredible strategic partner to us – ... would provide," said Dr. Aeron Tynes Hammack , ...
(Date:6/23/2016)... ... , ... In a new case report published today in STEM CELLS Translational ... lymphedema after being treated for breast cancer benefitted from an injection of stem cells ... this debilitating, frequent side effect of cancer treatment. , Lymphedema refers to ...
(Date:6/23/2016)... June 23, 2016 ... 2016;12(1):22-8 http://doi.org/10.17925/OHR.2016.12.01.22 Published recently ... peer-reviewed journal from touchONCOLOGY, Andrew D Zelenetz ... of cancer care is placing an increasing burden ... expensive biologic therapies. With the patents on many ...
Breaking Biology Technology: