Navigation Links
Research targets basic metabolism of disease-causing fungi, bacteria
Date:8/18/2010

Pablo Sobrado, assistant professor of biochemistry with the Fralin Life Science Institute at Virginia Tech, has received a $1.1 million grant from the National Science Foundation (NSF) to advance his research on the mechanism of iron acquisition in fungi and mycobacteria.

Iron is essential for all life. The level of free iron in humans is less than Aspergillus fumigatus and Mycobacterium tuberculosis need. To satisfy their metabolic needs and enable infection, these microbes secrete molecules called siderophores to obtain iron from the host. The synthesis of siderophores requires special enzymes. Sobrado is studying these enzymes. "Our aim is to understand how the enzymes activate molecular oxygen and attach it to the substrate molecules, lysine or ornithine, in the biosynthesis of siderophores," he said.

He reported in the July 2010 issue of the journal Biochemistry that the enzyme from A. fumigatus contains the cofactor flavin adenine dinucleotide (FAD) that reacts with molecular oxygen and forms a stable intermediate. The NSF grant will fund the research to elucidate the mechanism of action and the structure of the enzymes from A. fumigatus and M. tuberculosis, specifically, how they stabilize the intermediate and what regulates the specificity of the enzyme.

The paper, "Aspergillus fumigatus SidA is a highly specific ornithine hydroxylase with bound flavin cofactor," by Wyatt Chocklett and Sobrado, is available at www.ncbi.nlm.nih.gov/pubmed/20614882.

For the educational component of the NSF grant, Sobrado is collaborating with a group at the University of Pavia who are experts on protein crystallography. "Our students will travel to Italy to be trained in how to solve the structure of enzymes," he said. "The goal is to train global scientists."

The students will include members of Virginia Tech's Multi
'/>"/>

Contact: Susan Trulove
strulove@vt.edu
540-231-5646
Virginia Tech
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Wistar Institute researcher receives New Innovator award from NIH
2. NC State researchers get to root of parasite genome
3. White Mountain Research Station to host climate change conference
4. Stevens awarded $1M for advanced biofuels research
5. Researchers find animal with ability to survive climate change
6. Researchers find an essential gene for forming ears of corn
7. Researchers note differences between people and animals on calorie restriction
8. Researcher working on destruction of chemical weapons
9. Researchers study acoustic communication in deep-sea fish
10. Researchers discover that growing up too fast may mean dying young in honey bees
11. The Rett Syndrome Research Trust launches operations
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Research targets basic metabolism of disease-causing fungi, bacteria
(Date:4/13/2015)... YORK , April 13, 2015 ... by TechSci Research, "Global Biometrics Market Forecast & Opportunities, ... register a CAGR of around 14% till 2020. ... governments for large scale implementation and review of ... and launch of new products with greater efficiency, ...
(Date:4/6/2015)... , Apr. 6, 2015 NXT-ID, Inc. (NASDAQ: ... biometric authentication company focused on the growing mobile ... provisional patent 62/143028 for MINIATURE, MULTI-PURPOSE ... TRANSFER  NXT-ID introduces a new revolutionary ... patent surrounds the use of miniature antenna modules ...
(Date:4/1/2015)... OXFORD, Conn. , Apr. 1, 2015  NXT-ID, ... a biometric authentication company focused on the growing mobile ... number of Wocket smart wallets is underway to early ... early access group includes usage at retail outlets including ... CVS Pharmacy. Users report Wocket was accepted at all ...
Breaking Biology News(10 mins):Global Biometrics Market to Cross US$ 21 Billion by 2020: TechSci Research 2NXT-ID Patents Miniature, Low Power Wireless Magnetic Stripe 2NXT-ID Patents Miniature, Low Power Wireless Magnetic Stripe 3NXT-ID Patents Miniature, Low Power Wireless Magnetic Stripe 4NXT-ID Reports Second Shipment of Wocket Smart Wallets Underway to Early Access Pre-order Customers and Provides User Feedback 2NXT-ID Reports Second Shipment of Wocket Smart Wallets Underway to Early Access Pre-order Customers and Provides User Feedback 3NXT-ID Reports Second Shipment of Wocket Smart Wallets Underway to Early Access Pre-order Customers and Provides User Feedback 4
... immune response in the eyes of freshwater fishes has created ... in the journal Molecular Ecology . The study provides ... that parasitize Canadian fish. "Canada probably has the best ... amazed when we found four times more species of flukes ...
... three decades, oceanographers have been puzzled by the ability of ... very little nitrate, an essential algal nutrient. In this week,s ... along with coauthors Stephen Riser at the University of Washington ... mid-ocean algae obtain nitrate from deep water, as much as ...
... Md., June 24, 2010 The National Science Foundation ... to the American Society for Biochemistry and Molecular Biology ... across the nation. The initiative aims to improve ... foundational concepts and skills for the discipline and by ...
Cached Biology News:Adaptation is (not) in the eye of the beholder 2Researchers discover source of essential nutrients for mid-ocean algae 2Researchers discover source of essential nutrients for mid-ocean algae 3NSF grant will develop new online hub for biochemistry, molecular biology educators 2
(Date:4/16/2015)... 16, 2015  In recognition of World Hemophilia Day, ... groups to illuminate more than 15 prominent landmarks red throughout ... Boston,s Zakim Bridge and Prudential Tower, ... Mercedes-Benz Superdome and Denver,s ... of April 17, and coincide with hemophilia community events in ...
(Date:4/16/2015)... (PRWEB) April 16, 2015 A new ... it easier for research institutions to learn how Apple’s ... data. , The timing is ideal since Apple made ... Research Kit is an open-source framework for developing medical ... provides a way for researchers to collect secure clinical ...
(Date:4/16/2015)... LAUSANNE , Switzerland ... Debiopharm International SA (Debiopharm), part of Debiopharm Group ™ ... prescription drugs that target unmet medical needs ... that preclinical data on the investigational compounds ... inhibitor) will be presented at the 2015 ...
(Date:4/16/2015)... (PRWEB) April 16, 2015 Modality ... management systems for highly regulated industries, is pleased ... name a monthly columnist for Cold Chain IQ ... http://www.coldchainiq.com ). His column titled, Global Cold Chain ... information for today’s life sciences, pharmaceutical and healthcare ...
Breaking Biology Technology:Biogen Shines A Light On Hemophilia Community By Illuminating U.S. Landmarks Red On World Hemophlia Day 2Biogen Shines A Light On Hemophilia Community By Illuminating U.S. Landmarks Red On World Hemophlia Day 3Biogen Shines A Light On Hemophilia Community By Illuminating U.S. Landmarks Red On World Hemophlia Day 4Infographic Illustrates Potential for Research Kit to Impact Clinical Research 2Infographic Illustrates Potential for Research Kit to Impact Clinical Research 3Debiopharm International SA Announces Results of 2 Key Oncology Programs at 2015 AACR Conference 2Debiopharm International SA Announces Results of 2 Key Oncology Programs at 2015 AACR Conference 3Modality Solutions Gary Hutchinson Named Columnist for Cold Chain IQ 2Modality Solutions Gary Hutchinson Named Columnist for Cold Chain IQ 3
... 7 /PRNewswire-FirstCall/ - Oncothyreon Inc. (the,"Company") (Nasdaq: ... development of innovative therapeutic products for the treatment ... its fourth quarter and,full year 2007 financial results ... the U.S. and Canadian markets. Following the release, ...
... Corporation,(Nasdaq: ACEL ) today reported its financial results ... recorded a net loss of approximately $1.7 million, or ... fiscal quarter ended,Jan. 31, compared to a net loss ... share, for the second quarter of fiscal 2007. The ...
... PARK, Ill., March 7 Abbott (NYSE: ... Annual Global Healthcare,Conference on Tuesday, March 18, 2008. ... financial officer, will make a formal,presentation on the ... live audio webcast of the presentation will be ...
Cached Biology Technology:Alfacell Reports Financial Results for Second Quarter of Fiscal 2008 2Alfacell Reports Financial Results for Second Quarter of Fiscal 2008 3Alfacell Reports Financial Results for Second Quarter of Fiscal 2008 4Alfacell Reports Financial Results for Second Quarter of Fiscal 2008 5
Includes a choice of any 3 EasySep mouse selection kits and EasySep magnet...
... 1.5mg of purified RNA samples., , This ... of aqueous RNA samples that have been ... phenol/chloroform, silica, oligo dT etc or other ... the necessary components for the stabilization of ...
Human SEAP ORF, provided in a pORF plasmid. pORF is an expression plasmid selectable with Ampicillin....
...
Biology Products: