Navigation Links
Research supports toxoplasmosis link to schizophrenia
Date:3/11/2009

Scientists have discovered how the toxoplasmosis parasite may trigger the development of schizophrenia and other bipolar disorders.

The team from the University of Leeds' Faculty of Biological Sciences (UK) has shown that the parasite may play a role in the development of these disorders by affecting the production of dopamine - the chemical that relays messages in the brain controlling aspects of movement, cognition and behaviour.

Toxoplasmosis, which is transmitted via cat faeces (found on unwashed vegetables) and raw or undercooked infected meat, is relatively common, with 10-20% of the UK population and 22% of the US population estimated to carry the parasite as cysts. Most people with the parasite are healthy, but for those who are immune-suppressed - and particularly for pregnant women - there are significant health risks that can occasionally be fatal.

Dr Glenn McConkey, lead researcher on the project, says: "Toxoplasmosis changes some of the chemical messages in the brain, and these changes can have an enormous effect on behaviour. Studies have shown there is a direct statistical link between incidences of schizophrenia and toxoplasmosis infection and our study is the first step in discovering why there is this link."

The parasite infects the brain by forming a cyst within its cells and produces an enzyme called tyrosine hydroxylase, which is needed to make dopamine. Dopamine's role in mood, sociability, attention, motivation and sleep patterns are well documented and schizophrenia has long been associated with dopamine, which is the target of all schizophrenia drugs on the market.

The team has recently received $250,000 (160,000) to progress its research from the US-based Stanley Medical Research Institute, which focuses on mental health conditions and has a particular emphasis on bipolar illnesses.

Dr McConkey says: "It's highly unlikely that we will find one definitive trigger for schizophrenia as there are many factors involved, but our studies will provide a clue to how toxoplasmosis infection - which is more common than you might think can impact on the development of the condition in some individuals.

"In addition, the ability of the parasite to make dopamine implies a potential link with other neurological conditions such as Parkinson's Disease, Tourette's syndrome and attention deficit disorders, says Dr McConkey. "We'd like to extend our research to look at this possibility more closely."


'/>"/>

Contact: Jo Kelly
jokelly@campuspr.co.uk
44-113-258-9880
University of Leeds
Source:Eurekalert  

Related biology news :

1. Research shows skeleton to be endocrine organ
2. Newly created cancer stem cells could aid breast cancer research
3. Dominant cholesterol-metabolism ideas challenged by new research
4. Researchers identify proteins involved in new neurodegenerative syndrome
5. Texas researchers and educators head for Antarctica
6. MGH researchers describe new way to identify, evolve novel enzymes
7. University of Pennsylvania researchers develop formula to gauge risk of disease clusters
8. University of Oregon researcher finds that on waters surface, nitric acid is not so tough
9. U of MN researchers discover noninvasive diagnostic tool for brain diseases
10. U of Minnesota researchers discover noninvasive diagnostic tool for brain diseases
11. Story ideas from the Journal of Lipid Research
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Research supports toxoplasmosis link to schizophrenia
(Date:3/2/2017)... Australia , March 2, 2017 Australian ... Ltd (ASX: CYP), has signed an agreement with ... from the Monash Biomedicine Discovery Institute and Department of ... to conduct a further preclinical study to support the ... treatment of asthma.  Asthma is a ...
(Date:2/27/2017)...   Strategic Cyber Ventures , the industry,s first ... $3.5 million investment in  Polarity , the first commercial ... DC based and is led by cybersecurity veterans ... Ron Gula , also a longtime cybersecurity veteran and ... series A round of funding. This new funding will ...
(Date:2/21/2017)... 2017 Der weltweite Biobanking-Sektor wird ... einem Gespräch mit mehr als 50 Vertretern aus verschiedenen Branchen ... gilt, um diese Prognose zu realisieren. ... Zu den ... finanziellen Mittel für die Biobank, die Implementierung Zeit sparender ...
Breaking Biology News(10 mins):
(Date:3/28/2017)... Calif. , March 28, 2017 ... of international life sciences corporation Anpac Bio-Medical ... set a new, international record, processing and reporting ... "Cancer Differentiation Analysis" (CDA) liquid biopsy ... World Nobel Prize Laureate Summit publications, Anpac Bio,s ...
(Date:3/28/2017)... , ... March 28, 2017 , ... ... and diminished effectiveness over time. A recent study published in STEM CELLS suggests ... stimulating subventricular zone (SVZ) stem cells to produce more neural cells. , ...
(Date:3/28/2017)... , March 28, 2017 /PRNewswire/ -RepliCel Life Sciences Inc. (OTCQB: ... to report compelling safety and clinical data from its phase ... 1 collagen-expressing, hair follicle-derived fibroblasts (RCT-01) as a treatment for ... ... a complete safety profile at 6 months and showed no ...
(Date:3/27/2017)... 2017 Roka Bioscience, Inc. (NASDAQ: ROKA), a molecular ... detection of foodborne pathogens,  today announced that Mary Duseau ... 2017 Convention on March 29 at 9:50am ET. The conference ... About Roka Bioscience ... Roka Bioscience is a molecular ...
Breaking Biology Technology: