Navigation Links
Research supports promise of cell therapy for bowel disease
Date:2/27/2013

WINSTON-SALEM, N.C. Feb. 28, 2013 Researchers at Wake Forest Baptist Medical Center and colleagues have identified a special population of adult stem cells in bone marrow that have the natural ability to migrate to the intestine and produce intestinal cells, suggesting their potential to restore healthy tissue in patients with inflammatory bowel disease (IBD).

Up to 1 million Americans have IBD, which is characterized by frequent diarrhea and abdominal pain. IBD actually refers to two conditions ulcerative colitis and Crohn's disease in which the intestines become red and swollen and develop ulcers, probably as the result of the body having an immune response to its own tissue.

While there is currently no cure for IBD, there are drug therapies aimed at reducing inflammation and preventing the immune response. Because these therapies aren't always effective, scientists hope to use stem cells to develop an injectable cell therapy to treat IBD.

The research findings are reported online in the FASEB Journal (the journal of the Federation of American Societies for Experimental Biology) by senior researcher Graca Almeida-Porada, M.D., Ph.D., professor of regenerative medicine at Wake Forest Baptist's Institute for Regenerative Medicine, and colleagues.

The new research complements a 2012 report by Almeida-Porada's team that identified stem cells in cord blood that are involved in blood vessel formation and also have the ability to migrate to the intestine.

"We've identified two populations of human cells that migrate to the intestine one involved in blood vessel formation and the other that can replenish intestinal cells and modulates inflammation," said Almeida-Porada. "Our hope is that a mixture of these cells could be used as an injectable therapy to treat IBD."

The cells would theoretically induce tissue recovery by contributing to a pool of cells within the intestine. The lining of the intesti
'/>"/>

Contact: Karen Richardson
krchrdsn@wakehealth.edu
336-716-4453
Wake Forest Baptist Medical Center
Source:Eurekalert

Page: 1 2

Related biology news :

1. Study by UC Santa Barbara researchers suggests that bacteria communicate by touch
2. Research reveals first evidence of hunting by prehistoric Ohioans
3. Diabetes Research Institute develops oxygen-generating biomaterial
4. APS issues new policy requiring identification of sex or gender in reporting scientific research
5. UC Santa Barbara researchers discover genetic link between visual pathways of hydras and humans
6. Study jointly led by UCSB researcher supports theory of extraterrestrial impact
7. U of Alberta researcher steps closer to understand autoimmune diseases
8. Research on flavanols and procyanidins provides new insights into how these phytonutrients may positively impact human health
9. A project to research biological and chemical aspects of microalgae to fuel approach
10. Scripps Research discoveries lead to newly approved drug for infant respiratory distress syndrome
11. Researchers attempt to solve problems of antibiotic resistance and bee deaths in one
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/11/2015)... SAN JOSE, Calif. , May 11, 2015 ... leading developer of human interface solutions, today announced ... Senior Vice President and Chief Financial Officer, reporting ... Mr. Ali replaces Synaptics, current Chief Financial Officer, ... in December 2014. Mr. Ali ...
(Date:5/8/2015)... 8, 2015 Synaptics Inc. (NASDAQ: SYNA ), ... members of the executive management team will present at the ... Media and Telecom Conference Date: May 18, 2015 ... Boston, MA Cowen and Company Technology, ... ET Location: The New York Palace Hotel, New ...
(Date:4/27/2015)... -- For more than four decades, AUVSI,s Unmanned Systems ... worldwide event for the unmanned land, sea, and air ... any local, national, or trade news organization interested in ... current applications of unmanned technologies. The conference will explore ... industry, and how it will soon impact the lives ...
Breaking Biology News(10 mins):Synaptics Appoints Wajid Ali as Senior Vice President and Chief Financial Officer 2Synaptics to Present at Upcoming Investor Conferences 2UNMANNED SYSTEMS 2015: Largest International Conference and Trade Show for the Drone and Unmanned Technology Industry 2UNMANNED SYSTEMS 2015: Largest International Conference and Trade Show for the Drone and Unmanned Technology Industry 3UNMANNED SYSTEMS 2015: Largest International Conference and Trade Show for the Drone and Unmanned Technology Industry 4UNMANNED SYSTEMS 2015: Largest International Conference and Trade Show for the Drone and Unmanned Technology Industry 5
... - GEOLOGY topics include the fossil conservation ... as carbon; an habitable zone model for recovery after ... climate and tectonics; the "celebrated weirdness of Ediacaran fossils" ... way to concentrate gold. GSA TODAY compares ...
... -- Next month in Boston, the AVS 55th International ... spectrum of science and engineering devoted to discoveries on ... in other controlled environments used to develop new materials ... professional society, and its members come from universities, government ...
... HEAD, SCOne out of every three Americans is obese. These ... obesity leads to other health problems, such as diabetes. ... metabolism in the muscle. As a result, accumulated fat ... build up of fat by-products, fat must either be oxidized ...
Cached Biology News:October 2008 GEOLOGY and GSA TODAY media highlights 2October 2008 GEOLOGY and GSA TODAY media highlights 3October 2008 GEOLOGY and GSA TODAY media highlights 4October 2008 GEOLOGY and GSA TODAY media highlights 5October 2008 GEOLOGY and GSA TODAY media highlights 6October 2008 GEOLOGY and GSA TODAY media highlights 7October 2008 GEOLOGY and GSA TODAY media highlights 8October 2008 GEOLOGY and GSA TODAY media highlights 9October 2008 GEOLOGY and GSA TODAY media highlights 10Save-the-date: Major nanotech, energy, and biomed meeting 2Save-the-date: Major nanotech, energy, and biomed meeting 3Save-the-date: Major nanotech, energy, and biomed meeting 4For insulin sensitive overweight patients, 1 session of exercise improves metabolic health 2
(Date:5/20/2015)... Research and Markets ( http://www.researchandmarkets.com/research/x4b7kw/top_technologies ) ... in HW_Technical Insights" report to their offering. ... trends in the Health and Wellness sector and has ... an impact in the year 2015. The research service ... health and wellness technologies that are anticipated to have ...
(Date:5/20/2015)... 19, 2015 Research and Markets ( ... "Global Cell Therapy Market Outlook 2020 " report ... in tissue and regenerative medicine is expected to have ... which could help in the growth of deregulated organs. ... they are unable to form new tissue or sometimes ...
(Date:5/20/2015)... 20, 2015 The global genotyping market ... during the forecast period of 2015 to 2020 to ... used in drug discovery and development process and to ... In addition to this,heavy investments by key manufacturers to ... also propelling market growth. Browse 113 market data tables ...
(Date:5/20/2015)... May 20, 2015 Agricultural firm H.J. ... of its acquisition of Tiger-Sul. Since the purchase ... Alberta, Canada) in May 2005, H.J. Baker has leveraged ... it into a comprehensive portfolio of product offerings and ... H.J. Baker and the innovation of Tiger-Sul, transforming the ...
Breaking Biology Technology:Top Technologies in the Health and Wellness Industry 2015 2Global Cell Therapy Market Outlook 2015-2020 - 262 Cell Therapies & 13 Marketed Cell Therapies 2Global Cell Therapy Market Outlook 2015-2020 - 262 Cell Therapies & 13 Marketed Cell Therapies 3Genotyping Market Growing at 22.3% CAGR to 2020: Research Based on Technology, Applications, Opportunities, Challenges and Key Players. 2Genotyping Market Growing at 22.3% CAGR to 2020: Research Based on Technology, Applications, Opportunities, Challenges and Key Players. 3Genotyping Market Growing at 22.3% CAGR to 2020: Research Based on Technology, Applications, Opportunities, Challenges and Key Players. 4Genotyping Market Growing at 22.3% CAGR to 2020: Research Based on Technology, Applications, Opportunities, Challenges and Key Players. 5Agricultural Firm H.J. Baker & Bro., Inc., Celebrates 10 Years Since Acquisition Of Tiger-Sul 2Agricultural Firm H.J. Baker & Bro., Inc., Celebrates 10 Years Since Acquisition Of Tiger-Sul 3
... Wis. What are you doing for Healthcare ... marking the event, declared officially by governor Jim Doyle, ... on May 3 and 4. , ,Healthcare IT Week ... people healthy and to the Wisconsin economy. Major healthcare ...
... - To address non-existent sales to the nation's small ... provide grants to small colleges to help them acquire ... colleges produce some novel scientific research, but they don't ... tools. As part of what DNASTAR calls the Rising ...
... may be improving the way educational institutions and businesses communicate ... automated rich media communications technology, still lost nearly $1 million ... ,The company, which still expects to reach the break-even point ... per share for the quarter. Although $255,000 of the loss ...
Cached Biology Technology:Digital Healthcare Conference marks Wisconsin's Healthcare IT Week 2Digital Healthcare Conference marks Wisconsin's Healthcare IT Week 3Small colleges get their own grant program 2Small colleges get their own grant program 3Sonic Foundry reports quarterly loss, higher Mediasite sales 2
...
Peptide-affinity Purified Polyclonal Antibody to Sphingolipid Receptor Edg8/S1P5...
...
... Collect eliminates manual data entry by ... into any Windows-based application. Collect is ... countless hours of tedious data entry. ... balances, scales, pH meters, spectrophotometers, force gauges, ...
Biology Products: