Navigation Links
Research spinoff ReXceptor gets license for Alzheimer's treatment
Date:4/25/2013

erim director of technology management and the chief executive officer for ReXceptor. Essentially, the researchers hope to prove that the medication acts on amyloid beta in the human brain in a manner similar to the one observed in animal studies. In lay terms, bexarotene functions as a kind of chaperone that escorts the problematic protein out of the cerebral area.

"This is an important proof-of-mechanism study that is a prerequisite for subsequent clinical evaluation of this drug in Alzheimer's patients," Landreth explained.

To date ReXceptor has secured $1.4 million to advance its work. This support includes a landmark collaboration between the Alzheimer's Drug Discovery Foundation and the BrightFocus Foundation to fund early-stage research. The arrangement includes The Charles Evans Foundation/Alzheimer's Drug Discovery Award to ReXceptor of $500,000 and a $250,000 contribution from BrightFocus to the collaboration with ADDF. The company also received two anonymous investments totaling $450,000, and $200,000 from Case Western Reserve.

This new funding has allowed ReXceptor to enter into a formal partnership with C2N Diagnostics, which will assist the company with the initiation and coordination of the clinical trial. C2N Diagnostics will provide its proprietary stable isotope labeling (SILK) platform to measure the metabolism of both brain-derived amyloid beta and apolipoprotein E in the human clinical study.

Haag credited the university's Office of Research and Technology Management, along with the medical school's chief translational officers and Council to Advance Human Health, with providing critical guidance and support in bringing the company to this stage.


'/>"/>

Contact: Marv Kropko
mrk107@case.edu
216-368-6890
Case Western Reserve University
Source:Eurekalert

Page: 1 2

Related biology news :

1. New research projects to enhance bioinformatics and computational biology tools and methodologies
2. Researchers pinpoint how trees play role in smog production
3. CNIO researchers capture the replication of the human genome for the first time
4. Cleveland Clinic research shows gut bacteria byproduct predicts heart attack and stroke
5. Scientists awarded $5.5 million for wheat, rice blast research
6. New research points to benefits of eggs, even for those at cardiovascular risk
7. New research examines connection between inflammatory stimulus and Parkinsons disease
8. Penn State Hass avocado research poster wins American Society For Nutrition Annual Awards
9. Large animal models of Huntingtons disease offer new and promising research options
10. New research constructs ant family tree
11. Researchers abuzz over caffeine as cancer-cell killer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/4/2014)... nature, the right amount of death at the right ... according to new research that could help in understanding ... stocks. , In a paper in the journal ... researcher and European colleagues conclude that the kind of ... loss of individuals, or mortality, depends on the size ...
(Date:11/4/2014)... A majority of Madagascar,s 101 species of lemurs are ... for the rainforests they call home. A new study ... can have on rainforest tree populations, which raises concerns ... the region,s rich biodiversity. , A large proportion of ... Lemurs in turn disperse the seeds of their ...
(Date:11/3/2014)... weight and preterm birth are linked to increased risk ... in the American College of Rheumatology (ACR) journal, ... weight and pre-term babies were not at greater risk ... , According to the ACR, 27 million Americans over ... Symptoms of OA range from mild to severe and ...
Breaking Biology News(10 mins):When less is more: Death in moderation boosts population density in nature 2Gardeners of Madagascar rainforest at risk 2Gardeners of Madagascar rainforest at risk 3Preterm, low birth-weight babies may need new hips in adulthood 2
... incredibly temperature sensitive and can perceive changes of as little ... 8th issue of the journal Cell , a Cell ... rise, but also coordinate an appropriate response -- activating hundreds ... about the way that their DNA is packaged. The ...
... gardening world it may have always been considered a fact, ... watering your garden in the midday sun can lead to ... in New Phytologist , provides an answer that not ... for forest fires and human sunburn. "The problem ...
... project E! 3184 Odysseus has developed systems to ... tumours or other pathologies, from MRI or CT-scans. The ... location, for consultation in real time just before surgery. ... with the best possible diagnostic support, before real surgery ...
Cached Biology News:How plants 'feel' the temperature rise 2Can a drop of water cause sunburn or fire? 2A virtual liver, a better chance of life 2A virtual liver, a better chance of life 3
(Date:11/26/2014)... The Alliance for Safe Biologic ... European physicians at the "1 ST EuropaBio ... at the Spanish Ministry of Health, Social Services ... the Spanish Bioindustry Association (ASEBIO), included regulators from ... oncology and rheumatology societies, representatives from a hospital ...
(Date:11/26/2014)... Charlotte, NC (PRWEB) November 25, 2014 ... High Intensity Focused Ultrasound (HIFU) devices, recently participated ... “ Small Renal Mass 360° .” Key opinion ... and therapeutic advances related to small renal masses ... learn about different ablative technologies in hands-on labs. ...
(Date:11/26/2014)... Miles Holder, formerly of Micron Research and ... team as Sales/Marketing Manager. Mr. Holder has over 25 ... the graphite industry. , “We are thrilled to be ... Trinkley, VP of Market and Product Development for Graphel ... the graphite industry, along with his proven track record ...
(Date:11/26/2014)... , Nov. 25, 2014 Bio-Techne Corporation ... has appointed Robert Gavin to serve in ... the Protein Platforms Division.  Mr. Gavin will be responsible ... segment, which includes the ProteinSimple business acquired in July ... San Jose, California -based ProteinSimple develops ...
Breaking Biology Technology:ASBM Presents European Physicians Survey at Spanish Ministry of Health 2SonaCare Medical Supports American Urology Association’s Small Renal Mass 360° Summit 2SonaCare Medical Supports American Urology Association’s Small Renal Mass 360° Summit 3Miles Holder Joins Graphel Corporation as Sales/Marketing Manager 2Bio?Techne Announces Appointment Of Robert Gavin As Leader Of New Protein Platforms Division 2Bio?Techne Announces Appointment Of Robert Gavin As Leader Of New Protein Platforms Division 3
... 2011 The New York Stem Cell Summit is releasing ... the press and the general public understand more accurately the ... the United States today. Approximately 1 million patients ... mid-1980s in the United States. Harvesting stem ...
... 2011 Renmatix , the leading producer of cellulosic sugars, ... fuels company Amyris , has joined the Renmatix Board of ... Year" by the Philadelphia Business Journal , will fill the ... Melo comes to the Renmatix Board of Directors with rare ...
... Sept. 13Researchers at Vanderbilt University have developed a new technique ... biological tissue at multiple points simultaneously, a method that could ... grow and change shape. UV lasers are a ... make incisions by vaporizing one point at a time in ...
Cached Biology Technology:New York Stem Cell Summit Issues Adult Stem Cell Fact Sheet 2Amyris Chief Joins Renmatix BoD, New CFO Added to Company 2