Navigation Links
Research spinoff ReXceptor gets license for Alzheimer's treatment
Date:4/25/2013

CLEVELAND Case Western Reserve's Technology Transfer Office has granted an exclusive license of a novel Alzheimer's Disease (AD) treatment strategy to spinoff company ReXceptor Inc., which plans to initiate early-stage human clinical trials of the medication within the next few months.

Gary Landreth, PhD, the Riuko and Archie G. Co Professor of Neurosciences, and his then-graduate student, Paige Cramer, PhD, co-founded ReXceptor after discovering that bexarotene (a medication trademarked as Targretin) reversed AD symptoms in mice within 72 hours of a single dose of treatment. Published last year in the journal Science, their results drew international interest, including stories in the Wall Street Journal and on CNN.

The U.S. Food and Drug Administration originally approved bexarotene for the treatment of cutaneous T-cell lymphomasa form of skin cancerin 1999. But Landreth, director of the medical school's Alzheimer's Research Laboratory, Cramer and their colleagues found that the medication significantly clears amyloid beta, a protein implicated in the development of Alzheimer's disease when it accumulates in the brain.

The researchers demonstrated that a dose of bexarotene (a retinoid X receptor (RXR) agonist) clears amyloid beta build-up by 25 percent within six hours, an effect that lasted for up to three days. Cognitively impaired mice resumed normal behaviors (demonstrating a restored sense of smell and instinctive interest in nest-building) within 72 hours of receiving the drug.

More than 5.4 million Americans suffer from Alzheimer's disease today, and that figure is expected to more than triple by the year 2050. Translating Case Western Reserve's groundbreaking research into a treatment available for patients is a complex process, but the researchers have great hope for the promise of their approach.

The first stage of testing will involve healthy volunteers, explained Michael Haag, the university's int
'/>"/>

Contact: Marv Kropko
mrk107@case.edu
216-368-6890
Case Western Reserve University
Source:Eurekalert

Page: 1 2

Related biology news :

1. New research projects to enhance bioinformatics and computational biology tools and methodologies
2. Researchers pinpoint how trees play role in smog production
3. CNIO researchers capture the replication of the human genome for the first time
4. Cleveland Clinic research shows gut bacteria byproduct predicts heart attack and stroke
5. Scientists awarded $5.5 million for wheat, rice blast research
6. New research points to benefits of eggs, even for those at cardiovascular risk
7. New research examines connection between inflammatory stimulus and Parkinsons disease
8. Penn State Hass avocado research poster wins American Society For Nutrition Annual Awards
9. Large animal models of Huntingtons disease offer new and promising research options
10. New research constructs ant family tree
11. Researchers abuzz over caffeine as cancer-cell killer
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/11/2014)... with other group members to reduce aggression and gain ... strategy for grooming activities shows a certain pattern across ... scientific journal Biology Letters . , Grooming between ... without ulterior motives. To be groomed has hygienic benefits ... another individual can provide access to infants, mating opportunities ...
(Date:7/11/2014)... July 11, 2014 Researchers have pioneered a ... The new technology, called Virtual Finger, allows scientists ... like neurons and synapses using the flat surface ... makes 3D imaging studies orders of magnitude more ... unprecedented level across many areas of experimental biology. ...
(Date:7/11/2014)... addition to the hippocampus, the marginal division of ... memory. What is the impact degree of substance ... and memory function? Yan Yu and his team, ... found, using immunofluorescence staining, that substance P receptor, ... and striatal marginal division of normal rats. Unilateral ...
Breaking Biology News(10 mins):Baboons groom early in the day to get benefits later 2Virtual finger enables scientists to navigate and analyze complex 3D images 2
... Scientists are calling for more research on the possibility ... renowned for their apparent ability to prevent cancer ... individuals. Their recommendation follows a study in which two ... to aggravate kidney cancer in severely diabetic laboratory rats. ...
... the abstracts to be presented at the EORTC-NCI-AACR [1] Symposium on ... before the meeting at 00.01 hrs CET on Friday 29 October. ... are free to report on the online abstracts from the time ... bear in mind that all the abstracts had to be submitted ...
... , Blacksburg, Va. -- The USDA,s National Institute of ... the College of Agriculture and Life Sciences at Virginia ... grape and wine quality in the eastern United States. ... project director, the five-year project seeks to create, refine, ...
Cached Biology News:Abstracts for the EORTC-NCI-AACR Symposium in Berlin go up online on Friday, Oct. 29 2USDA awards Virginia Tech $3.8 million to stimulate eastern US wine industry 2
(Date:7/11/2014)... Cayenne Medical, Inc., a privately ... soft tissue reconstruction segment, announced the worldwide launch ... involving the shoulder and extremities. The SureLock System ... deployment method. The unique delivery eliminates manual tensioning ... or anchor displacement (also commonly know as anchor ...
(Date:7/10/2014)... 2014 Product and process impurities ... abundance and are often “lost in the noise,” ... Join presenters Dr. Rowel Tobias, Senior Scientist, Protein ... Head of Quality at Nanotherapeutics, Inc., to lear ... speed detection and quantitation while achieving the required ...
(Date:7/10/2014)... Understanding the need for better quality and ... gap that currently exists in this area, ChanTest has ... of validated ion channel and GPCR cell lines. ... ion channels control many critical physiological functions throughout the ... potential to treat a variety of human diseases. ...
(Date:7/10/2014)... CA (PRWEB) July 10, 2014 Unraveling ... closer together. The Archer Family purchased a ... within DNA, but ended up with a lifetime of ... contained within the family members’ DNA genuinely brought the ... decided to search deeper into genetic history and prior ...
Breaking Biology Technology:Cayenne Medical Launches SureLock™ All-Suture Anchor System for Shoulder and Extremity Surgery 2Cayenne Medical Launches SureLock™ All-Suture Anchor System for Shoulder and Extremity Surgery 3Novel Ms Techniques Speed Detection of Biopharmaceutical Product and Process Impurities, New Webinar Hosted by Xtalks 2Leader in Ion Channel Research Announces Newly Validated and Re-Engineered Cells 2Leader in Ion Channel Research Announces Newly Validated and Re-Engineered Cells 3Ancestry DNA Test Reveals a Controversial and Undiscovered Family History 2Ancestry DNA Test Reveals a Controversial and Undiscovered Family History 3Ancestry DNA Test Reveals a Controversial and Undiscovered Family History 4Ancestry DNA Test Reveals a Controversial and Undiscovered Family History 5
... GOLDEN, Colo., April 11 ABR-Affinity,BioReagents, a leading global ... Association for Cancer Research (AACR),and will exhibit at the ... April 12 - 16, 2008., "The AACR meeting ... we devote a,significant portion of our corporate resources to ...
... 11 Cord Blood America,Inc. (OTC Bulletin Board: ... ( http://www.cordblood-america.com ) focused on bringing,the life saving ... today said Pennsylvania has joined New York and ... women about the potential,benefits of umbilical cord blood ...
... CHAPEL HILL, N.C., April 10 Thought ... Home Depot, Qualcomm,Nationwide and others will address ... companies in today,s competitive economy at the ... Finding,Growing & Retaining Top Talent, sponsored by ...
Cached Biology Technology:ABR-Affinity BioReagents to Participate in the American Association for Cancer Research Meeting in San Diego, California, April 12 - 16, 2008 2Cord Blood America Says Pennsylvania Joins New York and California in Establishing Educational Programs on the Benefits of Umbilical Cord Blood Storage 2Pharmaceuticals & Biotechs to Share Insights for Developing Leaders in a Fast-Paced, Competitive Industry 2
... Versatile, modular, computer controlled pre-amplifier suitable for ... isolated electrode input for recording physiological signal ... and a transducer input for use with ... transducers. Additional options include a stimulus artefact ...
SYBR Green Nucleic Acid Dye...
... from an inert polymer with a unique split ... split septum caps for use with 384-well tall-chimney ... when used in conjunction with screw or clip-down ... pipetting equipment 384 septum caps may be ...
... ion chromatography system . The sensitive conductivity ... to 5000S, houses the measuring cell in a ... is available. Data processing is provided by ... is by the high pressure CE 4100 dual ...
Biology Products: