Navigation Links
Research shows immune system response is detrimental to novel brain cancer therapy
Date:12/4/2012

Boston -- For the first time, researchers have demonstrated that the response of natural killer (NK) cells is detrimental to glioblastoma virotherapy, a novel way of treating malignant brain cancer by injecting a virus into the tumor. A number of clinical trials are currently underway to test whether glioblastoma virotherapy will facilitate antitumor efficacy, but research led by E. Antonio Chiocca, MD, PhD, chairman of the Department of Neurosurgery at Brigham and Women's Hospital, and published in Nature Medicine, shows that in pre-clinical models, NK cells are killing off the virus infected cells, thus rendering the therapy less effective.

"This situation is similar to injecting a beneficial drug into a human and the drug is killed off because humans have an antibody against the drug," said Dr. Chiocca, the senior author of the research paper. "This finding will be of great interest to those who are studying experimental biology and tumors of the brain, as well as to patients with malignant brain tumors."

Dr. Chiocca hypothesizes that temporarily suppressing the immune system of glioblastoma patients on a short-term basis could counteract this response and allow the virotherapy work. The study may also expose novel targets to enhance therapy.For more information on the study, the entire manuscript, "NK cells impede glioblastoma virotherapy via NKp30 and NKp46 natural cytotoxicity receptors", is available in Nature Medicine.


'/>"/>

Contact: Tom Langford
tlangford@partners.org
617-534-1605
Brigham and Women's Hospital
Source:Eurekalert

Page: 1

Related biology news :

1. Fox invasion threatens wave of extinction, UC research finds
2. Stanford geoscientist cites critical need for basic research to unleash promising energy sources
3. University of Tennessee researchers find fungus has cancer-fighting power
4. Research, response for future oil spills: Lessons learned from Deepwater Horizon
5. Ocean Thin Films Announces Multispectral Imaging Research Grant Program
6. UC Davis researchers aid effort to sequence the complex wheat genome
7. UF researcher tests powerful new tool to advance ecology, conservation
8. Joslin researchers increase understanding of genetic risk factor for type 1 diabetes
9. Fracking in Michigan: U-M researchers study potential impact on health, environment, economy
10. NREL researchers use imaging technologies to solve puzzle of plant architecture
11. NIH-funded researchers show possible trigger for MS nerve damage
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/20/2016)... 2016 The rising popularity of mobility ... is stoking significant interest in keyless access systems. ... low energy (BLE), biometrics and near-field communication (NFC) ... of wireless technologies in the automotive industry. This ... access systems opens the market to specialist companies ...
(Date:12/16/2016)... Research and Markets has announced the addition ... to 2021" report to their offering. ... The biometric vehicle access system market, ... of 14.06% from 2016 to 2021. The market is estimated to ... 854.8 Million by 2021. The growth of the biometric vehicle access ...
(Date:12/15/2016)... ... has announced the addition of the "Global Military Biometrics Market 2016-2020" ... global military biometrics market to grow at a CAGR of 7.5% during ... on an in-depth market analysis with inputs from industry experts. The report ... The report also includes a discussion of the key vendors operating in ...
Breaking Biology News(10 mins):
(Date:1/19/2017)... LAKES, N.J. , Jan. 18, 2017 BD (Becton, ... technology company, announced today that it will host a live webcast ... at 1 p.m. (ET). The webcast can be ... be available for replay through Tuesday, January 31, 2017. ... About BD BD ...
(Date:1/18/2017)... 2017 Applied BioMath ( www.appliedbiomath.com ), ... research and development, today announced that Dr. ... of Applied BioMath, will present at the next ... Meeting on Thursday January 19, 2017 at the ... MA.   Dr. Burke,s talk "Quantitative Modeling and Simulation ...
(Date:1/18/2017)... ... January 18, 2017 , ... Whitehouse Labs ... Within Albany Molecular Research, Inc. (AMRI), the scientific staff dedicated to Extractables / ... planned for further growth in 2017. Extractable & Leachable evaluations have become increasingly ...
(Date:1/18/2017)... KING OF PRUSSIA, PA (PRWEB) , ... January ... ... to disrupt clinical operations again at the CHI SCOPE Summit for Clinical Ops ... and AstraZeneca in engaging panel discussions to examine vital clinical research issues such ...
Breaking Biology Technology: