Navigation Links
Research sheds light on the mechanics of gene transcription
Date:1/8/2008

est the generality of the findings beyond polytene nuclei to common (but much smaller and more difficult to test) diploid cells, the researchers used a technique called fluorescence in situ hybridization, which allowed them to detect the location of specific DNA sequences along a chromosome in fixed cells.

Looking at the location of co-regulated heat shock genes (genes that are transcribed simultaneously), they found that co-regulated pairs that occupied distinct sites before heat shock were no closer together after heat shock. As in the polytene chromosomes, the genes did not move to a single site for transcription.

And using fluorescence recovery after photobleaching -- another method engineered by Webb -- the researchers found that over time Pol II began to recycle itself within newly formed "compartments" around the activated gene.

"At some point you accumulate enough polymerase that it feeds back, so in a sense you've created a factory de novo" said Lis. "This is, to our knowledge, the first demonstration of Pol II recycling at a specific gene in vivo."

Lis and colleagues are now looking at other molecules involved in transcription to see if they behave similarly. "We're hoping to develop new ways to really see, in vivo, how gene regulation works mechanistically," he said.


'/>"/>

Contact: Blaine Friedlander
bpf2@cornell.edu
607-254-8093
Cornell University Communications
Source:Eurekalert  

Page: 1 2

Related biology news :

1. Research shows skeleton to be endocrine organ
2. Newly created cancer stem cells could aid breast cancer research
3. Dominant cholesterol-metabolism ideas challenged by new research
4. Researchers identify proteins involved in new neurodegenerative syndrome
5. Texas researchers and educators head for Antarctica
6. MGH researchers describe new way to identify, evolve novel enzymes
7. University of Pennsylvania researchers develop formula to gauge risk of disease clusters
8. University of Oregon researcher finds that on waters surface, nitric acid is not so tough
9. U of MN researchers discover noninvasive diagnostic tool for brain diseases
10. U of Minnesota researchers discover noninvasive diagnostic tool for brain diseases
11. Story ideas from the Journal of Lipid Research
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Research sheds light on the mechanics of gene transcription
(Date:4/17/2014)... inhibits RSV infection , Respiratory syncytial virus ... tract infections, generating life-threating illness in very young ... are limited. RSV enters host cells through the ... fusogenic bundle. Small interfering peptides that prevent bundle ... peptides are highly susceptible to degradation. In this ...
(Date:4/17/2014)... Gauthier and Professor Luca Razzari of the nergie ... large grants from the John R. Evans Leaders ... for the acquisition of state-of-the-art biotech and nanophotonics ... grants from the Ministre de l,Enseignement suprieur, de ... Technologie (MESRST). These new laboratories will help us ...
(Date:4/17/2014)... produce hydrogen sulfide in order to properly multiply and ... the Center for Craniofacial Molecular Biology at the Herman ... Shi, principal investigator on the project, said the presence ... flow of calcium ions. The essential ions activate a ... the creation of new bone tissue, and keeps the ...
Breaking Biology News(10 mins):JCI online ahead of print table of contents for April 17, 2014 2JCI online ahead of print table of contents for April 17, 2014 3JCI online ahead of print table of contents for April 17, 2014 4JCI online ahead of print table of contents for April 17, 2014 5JCI online ahead of print table of contents for April 17, 2014 6New state-of-the-art biotech and nanotech equipment for INRS 2
... one of the first efforts of its kind, UCLA researchers have ... showing not just the order in which genes fall in the ... findings, published in the August issue of the journal Genome ... and shed light on how they collaborate to help cells thrive ...
... mortality worldwide, accounting for more than one in ten deaths. ... million. The ESMO Congress provides a major international forum for ... Congress Program Highlights , , New ... new drugs to treat ovarian, skin, colorectal and other cancers, ...
... world is diagnosed with breast cancer every 23 seconds. It ... and approximately 456,000 die from the disease each year. At ... a scientist is taking aim at the molecular machinery behind ... G. Komen for the Cure, Catherine Denicourt, Ph.D., an assistant ...
Cached Biology News:UCLA scientists map all mammalian gene interactions 2UCLA scientists map all mammalian gene interactions 335th ESMO Congress media alert 235th ESMO Congress media alert 3
(Date:1/15/2014)... The Microcompetition with Foreign DNA theory explains how latent ... viruses is the Epstein Barr Virus (EBV), and one of ... a chronic inflammatory disease that destroys the body’s joints. As ... have high concentrations of EBV DNA in their bodies (1). ...
(Date:1/15/2014)... Freeslate, Inc ., the leading provider of ... one of India’s top five pharmaceutical companies, has received ... for high throughput solid form screening. , Lupin, ... range of quality, affordable generic and branded formulations and ...
(Date:1/14/2014)... (PRWEB) January 14, 2014 Date: Friday, April ... Location: Warrington Country Club, 1360 Almshouse Road, Warrington, Pa. ... nonprofit organization solely dedicated to finding a cure for hepatitis ... worldwide, will host its annual Crystal Ball on Friday, April ...
(Date:1/14/2014)... , Jan. 14, 2014  3D Communications, a leading provider of ... regulatory, business, and media events in the United States ... former associate Virginia Cox , JD, is returning to the ... Virginia Cox re-joins 3D after more than two years of ...
Breaking Biology Technology:Study: Rheumatoid Arthritis (RA) Patients Have EBV; The CBCD Says this is Consistent with Microcompetition 2Study: Rheumatoid Arthritis (RA) Patients Have EBV; The CBCD Says this is Consistent with Microcompetition 3Lupin Selects Freeslate’s CM Protégé PharmD System to Accelerate Polymorph Screening for Drug Development 2Lupin Selects Freeslate’s CM Protégé PharmD System to Accelerate Polymorph Screening for Drug Development 3Hepatitis B Foundation to Host Annual Crystal Ball Gala 2Former FDA Associate Commissioner Returns To 3D Communications 2
... has announced an exclusive contract with Trek Bicycle Corporation ... and Leum Software intend to enhance the current Ascend software ... help them manage their business with increased efficiency. , ,We ... successful. In the future, a dealers success will depend more ...
... effort to gather a burgeoning number of stem cell ... the University of Wisconsin-Madison has established the new Wisconsin ... of the UW-Madison Graduate School, the new initiative is ... efforts to develop new resources and opportunities for as ...
... Companies that do not specialize in software, but incorporate ... products, more often than not, overlook the importance of ... biggest feature or the most prevalent feature of the ... can and should be protected. , ,For example, ...
Cached Biology Technology:UW Madison launches new stem cell research program 2Beyond the screws and gears: Protecting your products by protecting your software 2
Request Info...
Purified anti-eIF-4E...
Peptide-affinity Purified Polyclonal Antibody to SMAD7 Peptide with sequence SSCPCWLEVIFNSR, from C Terminus of the protein sequence according to NP_005895....
Purified anti-PXR...
Biology Products: