Navigation Links
Research reveals new understanding, warning signs, and potential treatments for multiple sclerosis
Date:11/10/2013

SAN DIEGO Scientists are gaining a new level of understanding of multiple sclerosis (MS) that may lead to new treatments and approaches to controlling the chronic disease, according to new research released today at Neuroscience 2013, the annual meeting of the Society for Neuroscience and the world's largest source of emerging news about brain science and health.

MS is a severe, often crippling, autoimmune disease caused by the body's immune system attacking the nervous system. Today, more than two million people worldwide suffer from MS and other neuroinflammatory diseases. MS usually strikes in early adulthood and manifests with symptoms including vision loss, paralysis, numbness, and fatigue. The disease can be intermittent or progressive and currently has no cure.

Today's new findings show that:

  • Scientists are one step closer to understanding how antibodies in the blood stream break past the brain's protective barrier to attack the optic nerves, spinal cord, and brain, causing the symptoms of neuromyelitis optica, a rare disease similar to MS. Understanding how the antibodies bypass the protective blood-brain barrier could provide new approaches to treating the disease (Yukio Takeshita, MD, PhD, abstract 404.09, see attached summary).
  • A protein involved in blood clotting mightserve as an early detection method for MS before symptoms occur. Early detection of the disease could lead to more effective early treatments (Katerina Akassoglou, PhD, abstract 404.11, see attached summary).
  • Low levels of a cholesterol protein correlate with the severity of a patient's MS in both human patients and mouse models. The finding suggests the protein, known to protect against inflammation, may protect against developing MS, and possibly even aid in the regeneration of damaged neurons. This research opens the door to cholesterol drugs as a possible new avenue for MS treatment (Lidia Gardner, PhD, abstract 404.01, see attached summary).

Other recent findings discussed show that:

  • A type of immune system cell has been found to directly target and damage nerve cell axons, a hallmark of MS. This may reveal a target for new therapies (Brian Sauer, PhD, presentation 404.06, see attached speaker summary).
  • While no treatments to rebuild cells damaged by MS currently exist, scientists have found that when exosomes tiny, naturally occurring "nanovesicles" are produced by dendritic cells and applied to the brain, they can deliver a mixture of proteins and RNAs that promote regeneration of protective myelin sheaths and guard against MS symptoms (Richard Kraig, MD, PhD, presentation 812.02, see attached speaker summary).

"The findings shown today represent real promise for the millions suffering from MS," said press conference moderator Jeffrey Rothstein of Johns Hopkins University and an expert in neurodegenerative diseases. "These studies are breakthroughs in understanding and treating a disease that remains uncured, difficult to diagnose, and for which it is very difficult to prevent progression."


'/>"/>

Contact: Kat Snodgrass
media@sfn.org
202-962-4090
Society for Neuroscience
Source:Eurekalert

Related biology news :

1. Research by Saint Louis University scientists offers way to disrupt fibrosis
2. Research reveals roles for exercise and diet in aging, depression
3. NSF awards to UT Arlington researchers will fuel sustainable solutions
4. OHSU Vollum Institute research gives new insight into how antidepressants work in the brain
5. Researchers uncover origins of cattle farming in China
6. UT Southwestern researchers identify how body clock affects inflammation
7. Researchers suggest plan to address hypoxia in Gulf of Mexico
8. Researchers advocate for climate adaptation science
9. UMMS researchers answer century old question about 3D structure of mitotic chromosomes
10. NIH funds researchers using light to control and monitor neural activity
11. Researchers regrow hair, cartilage, bone, soft tissues
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/22/2016)... BETHESDA, Md. , June 22, 2016  The American ... by Trade Show Executive Magazine as one of ... Summit on May 25-27 at the Bellagio in ... based on the highest percentage of growth in each of ... number of exhibiting companies and number of attendees. The 2015 ...
(Date:6/20/2016)... Securus Technologies, a leading provider of ... safety, investigation, corrections and monitoring announced that after ... secured the final acceptance by all three (3) ... Systems (MAS) installed. Furthermore, Securus will have contracts ... by October, 2016. MAS distinguishes between legitimate wireless ...
(Date:6/9/2016)... TURKU, Finland , June 9, 2016 ... French National Police deploy Teleste,s video security solution to ensure ... France during the major tournament ... and data communications systems and services, announced today that its ... Police Prefecture to back up public safety across ...
Breaking Biology News(10 mins):
(Date:6/24/2016)... ... June 24, 2016 , ... Researchers at the Universita Politecnica delle Marche in ... peritoneal or pleural mesothelioma. Their findings are the subject of a new article on ... biomarkers are signposts in the blood, lung fluid or tissue of mesothelioma patients that ...
(Date:6/23/2016)... , June 23, 2016 /PRNewswire/ - FACIT has ... Ontario biotechnology company, Propellon Therapeutics Inc. ... and commercialization of a portfolio of first-in-class WDR5 ... targets such as WDR5 represent an exciting class ... in precision medicine for cancer patients. Substantial advances ...
(Date:6/23/2016)... MONICA, Calif. , June 23, 2016  The Prostate Cancer Foundation ... pioneer increasingly precise treatments and faster cures for prostate cancer. Members of the ... institutions across 15 countries. Read More About the Class ... ... ...
(Date:6/23/2016)... ... June 23, 2016 , ... STACS DNA Inc., the sample tracking software company, ... Crime Laboratory, has joined STACS DNA as a Field Application Specialist. , “I ... President and COO of STACS DNA. “In further expanding our capacity as a scientific ...
Breaking Biology Technology: