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Research reveals new clue in fight against TB in cattle
Date:5/22/2012

The failure of the current bovine tuberculosis (TB) eradication programme could be partly due to a parasitic worm that hinders the tests used to diagnose TB in cows, according to new research published this week.

Scientists at The Universities of Nottingham and Liverpool have discovered that a parasitic flatworm often found in cattle reduces the sensitivity of skin tests used to diagnose TB in the animals. The flatworm is called Fasciola hepatica, otherwise known as the common liver fluke.

Bovine TB is a bacterial disease that in 2011 resulted in the slaughter of approximately 25,000 cattle in England, at a cost to the country of more than 90 million. Solutions for eradicating the infection have included badger culling, but new research, published in Nature Communications, now suggests that the spread of the disease may also be due to problems in diagnosing it in cattle infected with the common livestock disease.

In a study of more than 3,000 dairy herds in England and Wales, scientists at Liverpool and in collaboration with Nottingham, the Agri-food and Biosciences Institute, Stormont, and University College Dublin, found that liver fluke infection reduces the effectiveness of skin tests used to diagnose bovine TB, effectively creating false negatives for TB in some.

Co-author of the research, Dr Robin Flynn, from The University of Nottingham's School of Veterinary Medicine and Science said: "We have been very interested in the ability of Fasciola hepatica to modulate host immunity for some time and this study is a worrying example of when this occurs in nature given an estimated 70-80 per cent of dairy herds show signs of liver fluke infection demonstrates the scale of this problem."

Professor Diana Williams, from the University of Liverpool's Institute of Infection and Global Health, said: "Tests to diagnose bovine TB rely on inflammation of the skin in response to injected TB proteins, but if the animal a
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Contact: Emma Rayner
emma.rayner@nottingham.ac.uk
44-011-595-15793
University of Nottingham
Source:Eurekalert

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