Navigation Links
Research reveals lipids' unexpected role in triggering death of brain cells
Date:11/12/2009

um signaling.

GM1-gangliosidosis is a lysosomal storage disorder in which an essential enzyme in the lysosomes is defective and cannot break down GM1. Lysosomes serve as the cell's digestive and recycling centers, stripping proteins, fats and other molecules down to their components so they can be used to assemble new molecules. Symptoms develop in childhood, in some cases shortly after birth, and include mental retardation, seizures and other problems. The outlook for patients remains bleak.

Normally, GM1 is found in the cell membrane. But previous work from d'Azzo's laboratory has shown that in patients with GM1-gangliosidosis, this lipid accumulates in other locations within the cell, including the membrane of the endoplasmic reticulum (ER). The ER is the structure where proteins are produced. GM1 accumulation in the ER membrane depletes the ER's calcium supply, disrupting the key protein-folding process. The disruption prompts the ER to target the cell for destruction.

In the current study, investigators extended their search for answers about the neurodegeneration in GM1-gangliosidosis to the mitochondria, another intracellular compartment. Some of the mitochondria are connected to the ER via the so-called mitochondria-associated ER membranes or MAMs. MAMs function like bridges, providing a route for calcium to move out of the ER and into the mitochondria. Researchers focused on the mitochondria because one of their cellular duties is to soak up and store excess intracellular calcium, including calcium from the ER.

Using a variety of techniques, researchers identified a region within MAMs where GM1 not only accumulates but sets the stage for step two of the calcium imbalance that triggers cellular suicide. Investigators reported that in healthy cells these regions, known as glycosphingolipid-enriched microdomains, or GEMs, include tiny amounts of GM1. But in mice lacking the enzyme to break down GM1, large amounts of this li
'/>"/>

Contact: Summer Freeman
summer.freeman@stjude.org
901-595-3061
St. Jude Children's Research Hospital
Source:Eurekalert

Page: 1 2 3 4

Related biology news :

1. Researchers gather in the UK to measure the impossible
2. £7.5 million ($12.6 million) collaborations lead UK research communitys response to H1N1 pandemic
3. Carnegie Mellon researchers to develop probes to study cellular GPS
4. Escaped proteins add to hearing loss in elderly, UF researchers find
5. CBS and OMD Partner to Provide the Agency With Access to the Networks Television City Research Facility in Las Vegas
6. Researchers complete draft genome sequence for cassava
7. £3.2m ($5.4 million) research project to capture brilliance of butterfly wings
8. Monell Center joins with CAS to host Beijing meeting on taste and smell research
9. Genomic research will enable greener cleanup of military explosive test sites
10. Tags reveal white sharks have neighborhoods in the north Pacific, say Stanford researchers
11. MSU researcher: Obesity significantly cuts odds of successful pregnancy
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/10/2014)...  Valencell, a leader in performance biometric data sensor ... from its licensees for highly accurate, clinically validated biometric ... coming from fitness and health sectors, but first responders/military ... is only as useful as the biometric data it ... in long-term mass consumer adoption of wearable products," said ...
(Date:12/10/2014)... , December 9, 2014 ... ITN,s BCARD Platform   ... enterprise meeting scheduling solutions for business-to-business (B2B) events, ... world leader in mobile near-field communication (NFC), Bluetooth ...      (Logo: http://photos.prnewswire.com/prnh/20140612/691055) , Jifflenow ...
(Date:12/3/2014)... Dec. 2, 2014   Marvin Test Solutions ... test solutions for military, aerospace, and manufacturing organizations, ... its successful TS-900 PXI semiconductor test platform ... of high-end systems to customers at a fraction ... to traditional ATE. "Our semiconductor ...
Breaking Biology News(10 mins):Wearable Technology Products Demand Highly Accurate Biometric Technology 2Jifflenow And ITN International Bring Cutting-Edge Badge Scanning Technology To B2B Events 2Jifflenow And ITN International Bring Cutting-Edge Badge Scanning Technology To B2B Events 3Marvin Test Solutions Brings New Capabilities to PXI-Based Semiconductor Test with TS-960 2Marvin Test Solutions Brings New Capabilities to PXI-Based Semiconductor Test with TS-960 3
... completing the sequencing of the chimpanzee genome last year, geneticists ... of our closest evolutionary relative, looking for the differences that ... found the human DNA sequence with the most dramatically increased ... DNA is still unknown, but it appears to be directly ...
... has become a worldwide health problem, affecting millions ... Researchers are experimenting with combinations of anti-inflammatory medicines ... research presented today at Digestive Disease Week® 2006 ... progress to improve symptoms of the disease. ...
... the University of Colorado-Denver and Health Sciences Center and ... how cells respond to DNA damage and other acute ... which could lead to new diagnostic markers and cancer ... reports in the May 21 advanced online version of ...
Cached Biology News:Researchers identify human DNA on the fast track 2Researchers identify human DNA on the fast track 3Novel therapy combinations gain ground in treating hepatitis 2Novel therapy combinations gain ground in treating hepatitis 3Novel therapy combinations gain ground in treating hepatitis 4Novel therapy combinations gain ground in treating hepatitis 5Novel therapy combinations gain ground in treating hepatitis 6Researchers uncover new mechanism of tumor suppressor 2
(Date:12/19/2014)... OR and Hershey, PA (PRWEB) December 19, 2014 ... Pink: BJCT), a leading developer and manufacturer of ... entered into an agreement with Immunomic Therapeutics, Inc. ... Biojector®-2000 needle-free injection device with its LAMP™ vaccine ... an option for an exclusive Worldwide license to ...
(Date:12/19/2014)... December 19, 2014 BioPlus Specialty ... pharmacies, announces the promotion of Nick Maroulis, Pharm.D. to ... Pharmacy Services. , In this position, Dr. Maroulis ... also managing the directors of our multi-site pharmacies as ... since 1997 and during that time he has served ...
(Date:12/19/2014)... , Dec. 19, 2014  Roche (SIX: RO, ROG; ... Technologies, Inc. (Bina), a privately held company based ... USA. Bina provides a big data platform for ... (NGS) data. Bina,s proprietary on-market Genomic Management Solution, ... researchers to perform fast and scalable analyses to ...
(Date:12/19/2014)... 19, 2014 Decision Resources Group finds that ... a 12 percent compound annual growth rate through 2023. ... population and the increasing adoption of dental implants. Growing ... will also spur demand for dental biomaterials because they ... periodontal treatments. Other key findings from Decision ...
Breaking Biology Technology:Bioject and Immunomic Therapeutics Enter into an Agreement for License of Needle-Free Technology for LAMP-vax Vaccines 2Bioject and Immunomic Therapeutics Enter into an Agreement for License of Needle-Free Technology for LAMP-vax Vaccines 3BioPlus Specialty Pharmacy Promotes Dr. Nick Maroulis to Vice President of Specialty Pharmacy Services 2Roche acquires Bina Technologies and enters the genomic informatics market 2Roche acquires Bina Technologies and enters the genomic informatics market 3Latin American Dental Biomaterial Market Will Expand at a 12 Percent Annual Growth Rate Through 2023 2Latin American Dental Biomaterial Market Will Expand at a 12 Percent Annual Growth Rate Through 2023 3
... - The 53 Wisconsin companies that won more ... Research (SBIR) and Small Business Technology Transfer (STTR) awards ... an upcoming banquet in Madison. , ,The awards banquet ... workshop. The workshop will focus on SBIR/STTR funding opportunities. ...
... Bend, Wis. - Serigraph Inc. will manufacture, ... tags through a licensing agreement with MIKOH Corp. ... tag if it is interfered with after its original positioning, ... from one item to another without affecting the function of ...
... is the biotech industry to the economy of a region? ... , ,Better yet, look at the numbers. , ,That's what ... Milken Institute , did for a landmark study released ... in Philadelphia. Philly leaders wanted to know where that city ...
Cached Biology Technology:Better collaboration urged to further Wisconsin biotech 2
All serum is collected from adult animals aged 6 months or older. Certified U.S. orgin. Pricing: $35/unit for 1 - 10 units...
adult...
DNA Purification...
Porcine Serum Available Anticoagulants: N-02: Citrate N-04: Heparin (Na) N-06: K2EDTA N-08: Potassium Oxalate N-10: EDTA (Na) N-03: Alsevers N-05: ACD N-07: CPD N-09: K3EDTA N-11...
Biology Products: