Navigation Links
Research reveals how dynamic changes in methylation can determine cell fate
Date:9/26/2011

e, which in this case was a gene encoding a B cell surface marker called CD22.

It has generally been thought that methylation is a stable epigenetic mark and that changes in methylation are unidirectional; and further, that cells become increasingly methylated as they move through the differentiation process toward their mature identity. And in fact, the only known direction of active change is from an unmethylated state to a methylated state.

The new data suggests, however, that dynamic changes in methylation status may be possible. The relevant evidence comes from blood stem cells, which were observed to have methylation patterns that the team describes as "intermediately methylated," seemingly in dynamic equilibria of the two extreme states of "methylated" and "unmethylated."

According to Hodges, this raises the possibility that methylation might in fact be bidirectional, and that there might be an as yet undiscovered, active mechanism that performs de-methylation. No known enzyme has this ability to remove methyl groups from DNA; DNA methyltransferase is the well-known enzyme that catalyzes the addition of methyl groups.

Yet another of the team's unexpected findings concerns the position of HMRs relative to know genic regions. While unmethylated regions tend to be associated with nearby genes that are capable of being expressed, the team found, according to Hodges, "a lot of HMRs located far away from any annotated gene locus." One notable thing about these regions, she says, "is that they were highly enriched for binding sites of specific regulatory molecules that are involved in chromatin organization."

Chromatin consists of DNA and the protein complexes called histones around which genomic DNA is packed. In a given cell, chromatin organization, like methylation, helps to determine whether specific genes can be expressed or not.


'/>"/>

Contact: Peter Tarr
tarr@cshl.edu
516-367-8455
Cold Spring Harbor Laboratory
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Researchers develop optimal algorithm for determining focus error in eyes and cameras
2. Researchers at Cruces Hospital describe new syndrome of slight family intellectual disability
3. Award-winning research points toward Alzheimer’s vaccine
4. GM food solutions at risk from lobbyists, research suggests
5. TGen breast cancer research benefits from $3.5 million Komen award
6. GCEP awards $3.5 million for energy research
7. UCLA researchers develop system that finds prostate cancer spread earlier than conventional imaging
8. MSU engages public on using newborn blood spots for research
9. Research into molluscan phylogeny reveals deep animal relationship of snails and mussels
10. UTHealth student earns fellowships to research major source of bacterial infections
11. Joslin researchers identify pathways leading to activation of good fat
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/9/2014)... how a complex protein pivotal in the development of ... discovery answers a key question about one of the ... the subject of tens of thousands of research papers ... Zhang, a research student in Professor Sir Philip Cohen,s ... protein complex, called NF-κB, is activated. The results ...
(Date:7/9/2014)... associate professor of plant pathology and microbiology ... the 2014 Alexopoulos Prize by the Mycological ... the science of mycology the study of fungi ... plant pathogens, and medically important fungi. , The award ... mycologist. Stajich received the award last month in East ...
(Date:7/9/2014)... selection refers to species, selection for traits that are ... natural selection enhances opportunities to mate, the tail of ... the University of California, Riverside have now found that ... placenta are linked. Describing the life histories of ... Poeciliidae, the researchers found that species with placentas tend ...
Breaking Biology News(10 mins):Research reveals how key controller protein is switched on 2UC Riverside plant pathologist receives national recognition 2Biologists link sexual selection and placenta formation 2Biologists link sexual selection and placenta formation 3Biologists link sexual selection and placenta formation 4
... Ph.D., assistant professor of chemistry in Arts & ... the National Institute of Mental Health for research ... Wiring." Maurer,s long term objective is ... a variety of neuronal wiring processes. He is ...
... KSContact with nature has long been suspected to ... from the pain associated with recovery from surgery. ... plants and flowers for patients recovering from abdominal ... and Richard H. Mattson, researchers from the Department ...
... New research in an animal model suggests that a ... a variety of processed foods including meats, cheeses, beverages, ... tumors and may even contribute to the development of ... The study also suggests that dietary regulation of inorganic ...
Cached Biology News:Chemist receives NIH funding to unravel tricks of neuronal wiring 2Flowering plants speed post-surgery recovery 2Common food additive found to increase risk and speed spread of lung cancer 2Common food additive found to increase risk and speed spread of lung cancer 3
(Date:1/15/2014)... The Microcompetition with Foreign DNA theory explains ... these latent viruses is the Epstein Barr Virus (EBV), and ... (RA) is a chronic inflammatory disease that destroys the body’s ... RA patients have high concentrations of EBV DNA in their ...
(Date:1/15/2014)... 2014 Freeslate, Inc ., the ... that Lupin Limited, one of India’s top five pharmaceutical ... PharmD System for high throughput solid form screening. ... on a wide range of quality, affordable generic and ...
(Date:1/14/2014)... January 14, 2014 Date: Friday, April 11, ... Warrington Country Club, 1360 Almshouse Road, Warrington, Pa. ... organization solely dedicated to finding a cure for hepatitis B ... will host its annual Crystal Ball on Friday, April 11 ...
(Date:1/14/2014)... Jan. 14, 2014  3D Communications, a leading provider of strategic communications ... and media events in the United States ... Virginia Cox , JD, is returning to the firm,s ... re-joins 3D after more than two years of service as ...
Breaking Biology Technology:Study: Rheumatoid Arthritis (RA) Patients Have EBV; The CBCD Says this is Consistent with Microcompetition 2Study: Rheumatoid Arthritis (RA) Patients Have EBV; The CBCD Says this is Consistent with Microcompetition 3Lupin Selects Freeslate’s CM Protégé PharmD System to Accelerate Polymorph Screening for Drug Development 2Lupin Selects Freeslate’s CM Protégé PharmD System to Accelerate Polymorph Screening for Drug Development 3Hepatitis B Foundation to Host Annual Crystal Ball Gala 2Former FDA Associate Commissioner Returns To 3D Communications 2
... 6 Omeros Corporation today announced that The Michael ... against milestones to support the Company,s collaboration with The ... new target for the treatment of Parkinson,s disease. Located ... Omeros is the first to link its novel target ...
... N.Y., Jan. 6 Dedicated to the memory ... fields of angiogenesis and vasculogenesis and shed light on the ... special double issue (Volume 6, Number 3-4) of ... papers that reflect the research impact of one of the ...
... Jan. 6 AutoGenomics, a leader in providing automated, ... been invited and has accepted to present at the ... 2009 at the Westin St. Francis Hotel in San ... CEO will provide an overview of the Company at ...
Cached Biology Technology:Omeros Awarded Grant from The Michael J. Fox Foundation to Evaluate Novel Parkinson's Disease Target 2Omeros Awarded Grant from The Michael J. Fox Foundation to Evaluate Novel Parkinson's Disease Target 3Festschrift Issue Honoring Judah Folkman, M.D. in Lymphatic Research and Biology 2Festschrift Issue Honoring Judah Folkman, M.D. in Lymphatic Research and Biology 3
Alkaline Phosphatase (E. coli C75), 100 units. Removes 5'-phosphates from DNA. Category: Nucleotides & Enzymes & Biochemicals, Modifying Enzymes, Alkaline Phosphatases....
... CyScribe First-Strand cDNA Labeling System - ... 50 reactions. For the generation and ... reagents are packaged together for complete ... protocols can be used for performing ...
... Post-Labeling Reactive Dye Pack, 12 x ... specifically optimized for microarray labeling.Higher reactivity ... reactive dye per vial, at > ... individually dispensed, and packed in foil ...
... CyScribe GFX Purification Kit, 24 reactions. ... Cy3- and Cy5-labeled cDNA.Optimized reagents are ... and purification.Flexible and optimized protocols can ... with either Cy3- or Cy5-labeled nucleotides.Reliable ...
Biology Products: