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Research project yields better understanding of the defective protein that causes cystic fibrosis
Date:12/18/2009

urn, regulates the transport of salt and bicarbonate. In the meantime, Sheppard said, if a cell needs to conserve energy, intracellular pH also can tell enzymes when it's time to shut down CFTR activity.

"(Chen's) original insights into CFTR structure and function have been critical to advancing knowledge of how CFTR normally works and how it goes wrong in disease," Sheppard said. "The aim is to design and develop drug therapies that restore function to CFTR proteins disabled by CF mutations. By targeting the root cause of the disease, rather than the symptoms, new drug therapies for CF might stop disease progression and prevent the decline in health of individuals living with CF."

Chen's research was funded by the Cystic Fibrosis Trust, the U.K. charity for CF research and patient care. His article has been named a "Paper of the Week" by the Journal of Biological Chemistry, putting it in the top 1 percent of papers reviewed by the editorial board in terms of significance and overall importance.

"Jeng-Haur Chen richly deserves this accolade. He is an enormously talented and committed researcher," Sheppard said.


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Contact: Angela Hopp
ahopp@asbmb.org
301-634-7389
American Society for Biochemistry and Molecular Biology
Source:Eurekalert  

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