Navigation Links
Research project yields better understanding of the defective protein that causes cystic fibrosis
Date:12/18/2009

protein back to its correct location, on the cell border, and second, when CFTR is defective, restoring function to it.

"CFTR itself is a small passageway with a gate, called an ion channel, found on the surface of cells lining ducts and tubes, where it acts as a pathway for the movement of chloride ions, one component of salt, and regulates the transport of bicarbonate, one part of soda," Chen explained.

By adjusting the transport of these molecules, he said, CFTR regulates the acid-base balance, or pH, of cells; and precise control of intracellular pH is vital for the function of all cells.

"In the case of cells lining ducts and tubes, intracellular pH regulates salt transport, protects the body against foreign invaders -- such as bacteria -- and controls cell survival," Chen said.

While scientists have had evidence that CFTR regulates pH in cells, it had been unknown how it detected changes in pH and knew when to adjust its activity. So, Chen set out to test his idea that CFTR activity is directly regulated by intracellular pH itself.

He successfully demonstrated that acid pH potently stimulates chloride transport by CFTR, whereas alkali pH inhibits it. To learn how pH regulates chloride transport via CFTR, Chen studied the function of the individual building blocks from which CFTR is assembled.

"The structure of CFTR resembles a turnstile -- it has a pathway for chloride movement across the cell border and a gate that controls access to this pathway. Turning of the gate is powered by adenosine triphosphate, or ATP, an energy source for all cells," explained David Sheppard, who oversaw Chen's work as a doctoral student in the department of physiology and pharmacology at the University of Bristol. "Jeng-Haur's work demonstrates that intracellular pH regulates ATP docking with the gate and the speed at which the gate turns."

Thus, intracellular pH determines the power level at the gate, which, in t
'/>"/>

Contact: Angela Hopp
ahopp@asbmb.org
301-634-7389
American Society for Biochemistry and Molecular Biology
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Research shows skeleton to be endocrine organ
2. Newly created cancer stem cells could aid breast cancer research
3. Dominant cholesterol-metabolism ideas challenged by new research
4. Researchers identify proteins involved in new neurodegenerative syndrome
5. Texas researchers and educators head for Antarctica
6. MGH researchers describe new way to identify, evolve novel enzymes
7. University of Pennsylvania researchers develop formula to gauge risk of disease clusters
8. University of Oregon researcher finds that on waters surface, nitric acid is not so tough
9. U of MN researchers discover noninvasive diagnostic tool for brain diseases
10. U of Minnesota researchers discover noninvasive diagnostic tool for brain diseases
11. Story ideas from the Journal of Lipid Research
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Research project yields better understanding of the defective protein that causes cystic fibrosis
(Date:2/5/2015)... --NXT-ID, Inc. (NASDAQ: NXTD and NXTDW) ... on the growing mobile commerce market, announces the launch ... part of its 2015 marketing and branding initiatives for ... consumer website for Wocketwallet.com earlier this month. ... "Our new corporate website naturally showcases our premiere consumer ...
(Date:2/5/2015)... 2015 Research and Markets ( ... "Global Biometrics Market (2014-2020): Market Forecast By ... report to their offering. , ... is anticipated to overtake North ... government spending towards IT security, government biometric based ...
(Date:1/22/2015)... Jan. 9, 2015 Valid S.A. ("Company") (BM&FBOVESPA: VLID3 ON), ... general the State of Washington,s Department ... new enrollment and central issuance system for driver,s licenses and ... The project planning and development will start in January 2015, ...
Breaking Biology News(10 mins):NXT-ID, Inc. Launches New Corporate Website As Part Of Ongoing 2015 Branding Initiatives For Wocket Smart Wallet 2NXT-ID, Inc. Launches New Corporate Website As Part Of Ongoing 2015 Branding Initiatives For Wocket Smart Wallet 3Global Biometrics Market (2014-2020): Market Forecast By Technologies, Applications, End Use, Regions and Countries 2Global Biometrics Market (2014-2020): Market Forecast By Technologies, Applications, End Use, Regions and Countries 3Valid USA Signs Contract For Washington Driver's License Issuance 2
... February 20, 2013As the nations of the world prepare ... endangered sharks in early March, a team of researchers ... oceanic whitetip shark regularly crosses international boundaries. Efforts ... within their own maritime borders may therefore need to ...
... programs that include dietary advice coupled with behavioral counseling ... approach for men and women with significant weight loss ... conducted by researchers at the Jean Mayer USDA Human ... Employees enrolled in the intervention arm of a randomized ...
... among the elements that make up today,s smorgasbord of planets, ... and his colleagues hope to learn how our solar system ... the University of California, San Diego, has worked on this ... his team has found the Chemical Dynamics Beamline of the ...
Cached Biology News:New research on migratory behavior of oceanic whitetip sharks can help shape conservation strategies 2New research on migratory behavior of oceanic whitetip sharks can help shape conservation strategies 3Employees shed pounds in worksite-based weight loss intervention with behavioral counseling 2Employees shed pounds in worksite-based weight loss intervention with behavioral counseling 3Searching for the solar system's chemical recipe 2Searching for the solar system's chemical recipe 3Searching for the solar system's chemical recipe 4Searching for the solar system's chemical recipe 5
(Date:3/4/2015)... 04, 2015 Proove Biosciences ... Medicine, is excited to announce the launch of ... Optimize the Management of Pain”. , The continuing ... for the next year. The focus of the ... recognize inadequate pain treatments, integrate appropriate pain management ...
(Date:3/4/2015)... SEOUL, South Korea , March 4, 2015 /PRNewswire/ ... based biopesticide company, in August of last year. As ... with Kyung Bon Koo continuing his role ... Selakovic , President of Vegalab S.A., will work alongside ... Photo - http://photos.prnewswire.com/prnh/20150303/179218 ...
(Date:3/4/2015)... PARIS , March 4, 2015 ... Hopitaux de Paris en ... «   SARAH   », qui compare   ... l,yttrium-90 avec le   sorafénib dans le carcinome ... atteints d,un cancer du foie avancé   ; ...
(Date:3/3/2015)... , March 3, 2015  Halozyme Therapeutics, Inc. (NASDAQ: ... Global Healthcare Conference in Miami, FL ... David A. Ramsay , Chief Financial Officer, will provide ... through the "Investors" section of Halozyme,s corporate website at ... 90 days following the event. To access the live webcast, ...
Breaking Biology Technology:Proove Biosciences Launches CME Accredited Program with Medscape 2Proove Biosciences Launches CME Accredited Program with Medscape 3Korean Government Program Supports Vegalab's Research and Development 2Korean Government Program Supports Vegalab's Research and Development 3Traitement du cancer primitif du foie : Recrutement terminé pour l'étude SARAH et résultats attendus fin 2016 2Traitement du cancer primitif du foie : Recrutement terminé pour l'étude SARAH et résultats attendus fin 2016 3Traitement du cancer primitif du foie : Recrutement terminé pour l'étude SARAH et résultats attendus fin 2016 4Traitement du cancer primitif du foie : Recrutement terminé pour l'étude SARAH et résultats attendus fin 2016 5Traitement du cancer primitif du foie : Recrutement terminé pour l'étude SARAH et résultats attendus fin 2016 6Halozyme Therapeutics To Present At The Barclays 2015 Global Healthcare Conference 2
... 13 /PRNewswire-Asia-FirstCall/ -- Tianyin,Pharmaceutical Co., Inc., (NYSE AMEX: ... Chinese medicine ("TCM") based in Chengdu, China, today,announced that ... and Drug,Administration (SFDA) to produce Sanqi Tablets in dosage ... Jiedu Tablets in,dosage form of 0.5 gram/tablet (SFDA approval ...
... , , CARLSBAD, ... a specialized laboratory services provider, today announced the Company,s participation at ... The Islands Hotel in Newport Beach, CA on August 18, 2009. ... of Investor Relations at Genoptix, will present at the conference on ...
... 13 Amsterdam Molecular,Therapeutics (Euronext: AMT), a leader in the field of ... 2009. , , Highlights, - Start ... in Canada following two previous clinical trials, - Presentation ... a clinically important health benefit, accomplished by a significant, ...
Cached Biology Technology:Tianyin Pharmaceutical Co., Inc. Receives Chinese SFDA Approval for Sanqi Tablets and Yinqiao Jiedu Tablets 2Tianyin Pharmaceutical Co., Inc. Receives Chinese SFDA Approval for Sanqi Tablets and Yinqiao Jiedu Tablets 3Genoptix Announces Participation at the 2009 Southern California Investor Conference 2Amsterdam Molecular Therapeutics Reports Half Year Results 2009 2Amsterdam Molecular Therapeutics Reports Half Year Results 2009 3Amsterdam Molecular Therapeutics Reports Half Year Results 2009 4
Anti-Mouse Qa.m7, Ascites (Clone 5035-50.1) (mouse IgM)...
Barcoded Slides, 5 Packs of 5 Slides (25/Case)...
Anti-Mouse Qa.m8, Ascites (Clone 5035-24.1) (mouse IgG3)...
... The 4700 Proteomics Analyzer Mass Standards Kit ... test instrument function, optimize instrument parameters, and ... standards. This kit is designed for use ... MALDI-TOF mass spectrometry system. Standards in the ...
Biology Products: