Navigation Links
Research project yields better understanding of the defective protein that causes cystic fibrosis
Date:12/18/2009

protein back to its correct location, on the cell border, and second, when CFTR is defective, restoring function to it.

"CFTR itself is a small passageway with a gate, called an ion channel, found on the surface of cells lining ducts and tubes, where it acts as a pathway for the movement of chloride ions, one component of salt, and regulates the transport of bicarbonate, one part of soda," Chen explained.

By adjusting the transport of these molecules, he said, CFTR regulates the acid-base balance, or pH, of cells; and precise control of intracellular pH is vital for the function of all cells.

"In the case of cells lining ducts and tubes, intracellular pH regulates salt transport, protects the body against foreign invaders -- such as bacteria -- and controls cell survival," Chen said.

While scientists have had evidence that CFTR regulates pH in cells, it had been unknown how it detected changes in pH and knew when to adjust its activity. So, Chen set out to test his idea that CFTR activity is directly regulated by intracellular pH itself.

He successfully demonstrated that acid pH potently stimulates chloride transport by CFTR, whereas alkali pH inhibits it. To learn how pH regulates chloride transport via CFTR, Chen studied the function of the individual building blocks from which CFTR is assembled.

"The structure of CFTR resembles a turnstile -- it has a pathway for chloride movement across the cell border and a gate that controls access to this pathway. Turning of the gate is powered by adenosine triphosphate, or ATP, an energy source for all cells," explained David Sheppard, who oversaw Chen's work as a doctoral student in the department of physiology and pharmacology at the University of Bristol. "Jeng-Haur's work demonstrates that intracellular pH regulates ATP docking with the gate and the speed at which the gate turns."

Thus, intracellular pH determines the power level at the gate, which, in t
'/>"/>

Contact: Angela Hopp
ahopp@asbmb.org
301-634-7389
American Society for Biochemistry and Molecular Biology
Source:Eurekalert  

Page: 1 2 3

Related biology news :

1. Research shows skeleton to be endocrine organ
2. Newly created cancer stem cells could aid breast cancer research
3. Dominant cholesterol-metabolism ideas challenged by new research
4. Researchers identify proteins involved in new neurodegenerative syndrome
5. Texas researchers and educators head for Antarctica
6. MGH researchers describe new way to identify, evolve novel enzymes
7. University of Pennsylvania researchers develop formula to gauge risk of disease clusters
8. University of Oregon researcher finds that on waters surface, nitric acid is not so tough
9. U of MN researchers discover noninvasive diagnostic tool for brain diseases
10. U of Minnesota researchers discover noninvasive diagnostic tool for brain diseases
11. Story ideas from the Journal of Lipid Research
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Research project yields better understanding of the defective protein that causes cystic fibrosis
(Date:7/29/2014)... Francisco is the first to show that while the ... aging, these negative effects may be reduced by maintaining ... "The study participants who exercised, slept well and ate ... didn,t maintain healthy lifestyles, even when they had similar ... assistant professor in the department of psychiatry at UCSF. ...
(Date:7/28/2014)... An international team of researchers led by the University ... rice. , The genetic information will enhance scientists, and ... as well as enable the development of new rice ... environmental stressors to help solve global hunger challenges. , ... Oryza glaberrima ) and evidence for independent domestication," was ...
(Date:7/28/2014)... School of Medicine have pinpointed a mechanism in part of ... the blood, linking it to both type 1 and type ... issue of Proceedings of the National Academies of Sciences ... located in a part of the hypothalamus known as ... motion that control glucose levels in the blood," said lead ...
Breaking Biology News(10 mins):Healthy lifestyle may buffer against stress-related cell aging, study says 2Generating a genome to feed the world: UA-led team sequences African rice 2Generating a genome to feed the world: UA-led team sequences African rice 3Generating a genome to feed the world: UA-led team sequences African rice 4Glucose 'control switch' in the brain key to both types of diabetes 2
... University Park, Pa. Health benefits from polyphenol antioxidants ... may come at a cost to some people. Penn ... the amount of iron the body absorbs, which can ... "Polyphenols have been known to have many beneficial effects ...
... biological invader that reaches its shores via cargo shipped ... Asian Longhorned Beetles, Kudzu, Triffid weed and others have ... harming human health and threatening biodiversity. The answer: ... of controlling invaders against the economic necessity of free ...
... brings debilitating side effects such as nausea, liver toxicity and ... way to deliver this life-saving therapy to cancer patients ― ... been invented by Dr. Dan Peer of Tel Aviv University,s ... Nano Science and Nano Technology together with Prof. Rimona Margalit ...
Cached Biology News:Polyphenol antioxidants inhibit iron absorption 2New analysis weighs lost trade, costs to control invasive species against economic damages 2New analysis weighs lost trade, costs to control invasive species against economic damages 3A cluster bomb for cancer care 2
(Date:7/29/2014)... 29, 2014 Second generation biofuels are a ... fossil fuels. However, as natural gas is very cheap, this ... are not as valuable as they could be in comparison ... financing projects, has made it difficult for renewable energy developers ... off the ground. For these reasons, certain companies have shifted ...
(Date:7/29/2014)... July 29, 2014 A new ... market (types, applications and geography) - Size, Share, Global ... Segmentation and Forecast, 2013 - 2020", suggests that the ... billion by 2020 registering a CAGR of 11.1% from ... achieved by the electro surgical devices in operative procedures ...
(Date:7/29/2014)... & Rockville, MD (PRWEB) July 29, 2014 ... Inc. (ITI), a vaccine pioneer in the biotechnology ... services firm Newport Coast Securities, Inc. to explore ... is commercializing LAMP-vax technology, a breakthrough vaccine platform ... and immunotherapy market. The company exclusively licensed the ...
(Date:7/29/2014)... Carolina (PRWEB) July 29, 2014 DisasterTalk is ... of people where cell phone masts or other transmitters are ... to 100 feet away without the need for any Wi-Fi, ... longer ranges. , The new app has launched as a ... homes are at very high risk of being affected by ...
Breaking Biology Technology:Renewable Waste Intelligence: Could Renewable Chemicals Be the Future for the Renewable Energy Industry? 2Global Surgical Equipment Market is expected to reach $12.1 billion by 2020 - Allied Market Research 2Global Surgical Equipment Market is expected to reach $12.1 billion by 2020 - Allied Market Research 3Immunomic Therapeutics Engages Newport Coast Securities, Inc. 2Immunomic Therapeutics Engages Newport Coast Securities, Inc. 3DisasterTalk App Could Save Lives as Report Reveals 8% of US Homes at Very High Risk of Natural Disaster 2
... Additional Phase 3 Trials on Track for Initiation Later ... for Today at 8:30 a.m. Eastern Time -, ... ARNA ) announced today that an independent Echocardiographic,Data Safety ... to stop,the ongoing pivotal Phase 3 trial, BLOOM (Behavioral ...
... Unit for $185 Million; Deal ... Expected to Close in the Fourth Quarter 2007, ... NABI ) announced today that it has entered into,a ... the Nabi,Biologics strategic business unit (SBU) to Biotest Pharmaceuticals,Corporation ...
... Ltd. (NASDAQ: XTLB ; LSE: XTL; TASE: XTL) ... 8:30 a.m. EDT to discuss the,Phase IIb clinical trial ... was initiated yesterday. Hosting the call will be ... will be two distinguished members of the diabetic,neuropathic pain ...
Cached Biology Technology:Arena Pharmaceuticals Continues Phase 3 BLOOM Obesity Trial Following Independent Echocardiogaphic Data Safety Monitoring Board Review 2Arena Pharmaceuticals Continues Phase 3 BLOOM Obesity Trial Following Independent Echocardiogaphic Data Safety Monitoring Board Review 3Arena Pharmaceuticals Continues Phase 3 BLOOM Obesity Trial Following Independent Echocardiogaphic Data Safety Monitoring Board Review 4Arena Pharmaceuticals Continues Phase 3 BLOOM Obesity Trial Following Independent Echocardiogaphic Data Safety Monitoring Board Review 5Arena Pharmaceuticals Continues Phase 3 BLOOM Obesity Trial Following Independent Echocardiogaphic Data Safety Monitoring Board Review 6Nabi Biopharmaceuticals Announces Sale of Nabi Biologics to Biotest AG 2Nabi Biopharmaceuticals Announces Sale of Nabi Biologics to Biotest AG 3Nabi Biopharmaceuticals Announces Sale of Nabi Biologics to Biotest AG 4Nabi Biopharmaceuticals Announces Sale of Nabi Biologics to Biotest AG 5Nabi Biopharmaceuticals Announces Sale of Nabi Biologics to Biotest AG 6Reminder: XTL to Hold a Conference Call Today at 8:30 am EDT to Discuss the Phase IIb Clinical Trial of Bicifadine for the Treatment of Diabetic Neuropathic Pain 2
US Pharmacopoeia Purified-Water/Water-for-Injection Quality Water...
... PinPoint™ Vector Sequencing Primer is designed for ... Vectors (Cat.# V2031, V2051, V2061). The primer ... at nucleotides 325343, approximately 4050 base pairs ... can be used to determine if an ...
Request Info...
...
Biology Products: