Navigation Links
Research points towards early cancer detection
Date:10/3/2007

A test to detect the very early stages of cancer could one day result from new research by Cardiff University scientists.

A team at the Universitys School of Medicine has just published a study on telomeres small structures at the end of human chromosomes which can play a crucial part in the onset of cancer.

Telomeres control cell division in the body - by gradually becoming shorter they can tell cells when it is time to stop dividing. However when telomeres stop working properly, they can cause the cells to mutate and start dividing uncontrollably, which can lead to the formation of tumours.

The Cardiff study used ground-breaking techniques to study telomeres in human cells. The researchers found the critical length at which telomeres stop working and also that some telomeres can be shortened or deleted at random, without any external cause.

The researchers also discovered how chromosomes can fuse together once they lose the protection of their telomeres. Chromosomal fusion causes the chromosomes to disintegrate, which can result in the development of cancerous growths. The Cardiff study means there is now a system which can detect chromosomal fusions from single DNA molecules, opening up the possibility of an early-warning test for cancer.

Project leader Dr Duncan Baird, of the School of Medicines Department of Pathology, said: This study threw up a number of significant results. The fact that telomeres can be deleted at random in otherwise normal cells indicates that some of the earliest cancerous changes can be initiated without any obvious extraneous influence. Our long-term aim with this research is to develop a clinical test to pick up these events. The fact we can now detect chromosome fusions at the single molecule level offers hope that we will be able to achieve it.

Dr Lesley Walker, director of cancer information at Cancer Research UK, which funded the research, said: Dr Baird and his team are making great strides in increasing our understanding of the very earliest stages of cancer by looking at these changes in single cells. It remains to be seen whether they can translate their technique and findings into a reliable test for early cancers.


'/>"/>

Contact: Stephen Rouse
RouseS@cardiff.ac.uk
44-029-208-75596
Cardiff University
Source:Eurekalert

Related biology news :

1. Researchers discover way to make cells in the eye sensitive to light
2. Quantum Dots Research Leads to New Knowledge about Protein Binding in Plants
3. Columbia research lifts major hurdle to gene therapy for cancer
4. Researchers find how protein allows insects to detect and respond to pheromones
5. Researchers Uncover Key Step In Manufacture of Memory Protein
6. Research advances quest for HIV-1 vaccine
7. Research on Worms Yields Clues on Aging
8. U of M researcher examines newly emerging deadly disease
9. NYU researchers simulate molecular biological clock
10. Researchers reveal the infectious impact of salmon farms on wild salmon
11. Researchers identify target for cancer drugs
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/24/2017)... The Controller General of Immigration from Maldives Mr. Mohamed ... received the prestigious international IAIR Award for the most innovative high security ... ... Maldives Immigration Controller General, ... picture on the right) have received the IAIR award for the "Most ...
(Date:3/23/2017)... -- The report "Gesture Recognition and Touchless Sensing Market by Technology ... Forecast to 2022", published by MarketsandMarkets, the market is expected to be worth ... and 2022. Continue Reading ... ... ...
(Date:3/22/2017)... Lithuania , March 21, 2017   ... and object recognition technologies, today announced the release ... kit (SDK), which provides improved facial recognition using ... cameras on a single computer. The new version ... to improve accuracy, and it utilizes a Graphing ...
Breaking Biology News(10 mins):
(Date:8/21/2017)... ... August 21, 2017 , ... Today Aether announced that Aether ... by a Bill and Melinda Gates Foundation grant, to pursue a ... Gates Foundation, also known as the Gates Foundation, is said to be the largest ...
(Date:8/18/2017)... San Jose, CA (PRWEB) , ... August 18, ... ... of advanced precision Lithography Equipment for the Semiconductor, MEMS, and Microfluidics Industries, announces ... offers features and specifications found more often in automated production mask aligners. OAI ...
(Date:8/17/2017)... ... August 17, 2017 , ... Cynvenio Biosystems, Inc., a ... the launch of a new breast cancer monitoring study in partnership with Saint ... the potential for early detection of recurrent breast cancer using LiquidBiopsy and natural ...
(Date:8/16/2017)... ... August 16, 2017 , ... ... Electrospinning and Electrospraying line of nanofiber and nanoparticle fabrication ... for the lab to fully automated pilot plants and equipment for industrial ...
Breaking Biology Technology: