Navigation Links
Research points towards early cancer detection
Date:10/3/2007

A test to detect the very early stages of cancer could one day result from new research by Cardiff University scientists.

A team at the Universitys School of Medicine has just published a study on telomeres small structures at the end of human chromosomes which can play a crucial part in the onset of cancer.

Telomeres control cell division in the body - by gradually becoming shorter they can tell cells when it is time to stop dividing. However when telomeres stop working properly, they can cause the cells to mutate and start dividing uncontrollably, which can lead to the formation of tumours.

The Cardiff study used ground-breaking techniques to study telomeres in human cells. The researchers found the critical length at which telomeres stop working and also that some telomeres can be shortened or deleted at random, without any external cause.

The researchers also discovered how chromosomes can fuse together once they lose the protection of their telomeres. Chromosomal fusion causes the chromosomes to disintegrate, which can result in the development of cancerous growths. The Cardiff study means there is now a system which can detect chromosomal fusions from single DNA molecules, opening up the possibility of an early-warning test for cancer.

Project leader Dr Duncan Baird, of the School of Medicines Department of Pathology, said: This study threw up a number of significant results. The fact that telomeres can be deleted at random in otherwise normal cells indicates that some of the earliest cancerous changes can be initiated without any obvious extraneous influence. Our long-term aim with this research is to develop a clinical test to pick up these events. The fact we can now detect chromosome fusions at the single molecule level offers hope that we will be able to achieve it.

Dr Lesley Walker, director of cancer information at Cancer Research UK, which funded the research, said: Dr Baird and his team are making great strides in increasing our understanding of the very earliest stages of cancer by looking at these changes in single cells. It remains to be seen whether they can translate their technique and findings into a reliable test for early cancers.


'/>"/>

Contact: Stephen Rouse
RouseS@cardiff.ac.uk
44-029-208-75596
Cardiff University
Source:Eurekalert

Related biology news :

1. Researchers discover way to make cells in the eye sensitive to light
2. Quantum Dots Research Leads to New Knowledge about Protein Binding in Plants
3. Columbia research lifts major hurdle to gene therapy for cancer
4. Researchers find how protein allows insects to detect and respond to pheromones
5. Researchers Uncover Key Step In Manufacture of Memory Protein
6. Research advances quest for HIV-1 vaccine
7. Research on Worms Yields Clues on Aging
8. U of M researcher examines newly emerging deadly disease
9. NYU researchers simulate molecular biological clock
10. Researchers reveal the infectious impact of salmon farms on wild salmon
11. Researchers identify target for cancer drugs
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/3/2016)... , May 3, 2016  Neurotechnology, a provider ... MegaMatcher Automated Biometric Identification System (ABIS) , ... multi-biometric projects. MegaMatcher ABIS can process multiple complex ... any combination of fingerprint, face or iris biometrics. ... SDK and MegaMatcher Accelerator , which ...
(Date:4/26/2016)... India and LONDON ... Infosys Finacle, part of EdgeVerve Systems, a product ... and Onegini today announced a partnership to integrate ... solutions.      (Logo: http://photos.prnewswire.com/prnh/20151104/283829LOGO ... to provide their customers enhanced security to access ...
(Date:4/15/2016)...  A new partnership announced today will help ... in a fraction of the time it takes ... life insurance policies to consumers without requiring inconvenient ... Diagnostics, rapid testing (A1C, Cotinine and HIV) and ... weight, pulse, BMI, and activity data) available at ...
Breaking Biology News(10 mins):
(Date:6/27/2016)... , June 27, 2016 /PRNewswire/ - BIOREM Inc. (TSX-V: BRM) ... advised by its major shareholders, Clean Technology Fund I, ... United States based venture capital funds which ... Biorem (on a fully diluted, as converted basis), that ... of their entire equity holdings in Biorem to TUS ...
(Date:6/27/2016)... ... June 27, 2016 , ... ... will join the faculty of the University of North Carolina Kenan-Flagler Business ... strategy and entrepreneurship at UNC Kenan-Flagler, with a focus on the school’s international ...
(Date:6/24/2016)... ... June 24, 2016 , ... While the majority of commercial spectrophotometers ... 5000 and the 6000i models are higher end machines that use the more unconventional ... spectrophotometer’s light beam from the bottom of the cuvette holder. , FireflySci has ...
(Date:6/23/2016)... TORONTO , June 23, 2016 /PRNewswire/ - ... Ontario biotechnology company, Propellon ... the development and commercialization of a portfolio of ... cancers. Epigenetic targets such as WDR5 represent an ... contribute significantly in precision medicine for cancer patients. ...
Breaking Biology Technology: