Navigation Links
Research pinpoints action of protein linked to key molecular switch
Date:4/19/2010

Chapel Hill, NC Rho proteins have been described as "molecular switches" and play a role in cell migration, cell proliferation, cell death, gene expression, and multiple other common cellular functions.

Understanding the actions of Rho proteins is important to illuminating cellular mechanisms related to cancer, which is fundamentally a disease of cell misbehavior. When cells multiply too rapidly, multiply and migrate into inappropriate places in the body, do not die after their natural lifespan or create networks of blood vessels where they should not, cancer results.

A study led by Keith Burridge, PhD, professor of cell and developmental biology, published online April 18 in the journal Nature Cell Biology, demonstrates that a protein called Rho GDI1 is a key to maintaining a balance of Rho proteins that allow optimal cellular functioning.

Traditionally scientists have understood the regulation of these proteins to be a function of "on" or "off" switching and that Rho GDI was a passive player in this process. This study demonstrates that the mechanism is more subtle, like a dimmer switch on a lighting panel that allows for a spectrum of levels. Rho proteins are inherently unstable because they are partially made up of a lipid (or fat). RhoGDI contains a "pocket" that can bind this lipid, thus protecting it.

One of the most important findings from this study is that changes in the expression level of one Rho protein can affect the expression levels and activities of other members of the family. In cells there is a limited amount of RhoGDI, and many different Rho proteins compete for binding to RhoGDI. The authors show that, when the protein levels of a particular Rho protein are artificially increased, the other Rho proteins are displaced from RhoGDI and degraded. Notably, previous studies have shown that many cancers exhibit altered levels of Rho proteins, raising the possibility that RhoGDI may be playing an important role in the biology of these cancer cells.

The authors hope that their work will help scientists better understand the subtle balancing mechanism that keeps cells functioning optimally, eventually leading to therapies that might target the balance of these proteins to prevent the cellular misbehavior that leads to cancers. The authors present preliminary results with two different cancer cell lines showing a correlation between the expression levels of RhoGDI and the levels and activities of Rho proteins.


'/>"/>

Contact: Ellen de Graffenreid
edegraff@med.unc.edu
919-962-3405
University of North Carolina School of Medicine
Source:Eurekalert  

Related biology news :

1. Researchers identify new gene involved in the development of liver cancer
2. Volcanic ash research shows how plumes end up in the jet stream
3. UMCES fisheries biologist Dr. David Secor receives USM Regents Faculty Award for research
4. UC Riverside entomologist recognized for research in citrus entomology
5. NIDCD-funded chemosensory researchers present findings at AChemS 2010 Meeting
6. Cancer health disparities research highlighted at AACR 101st Annual Meeting 2010
7. Advocates and researchers educate community about cancer in game show format
8. UDs Zhuang wins NSF Early Career Award for research on how cells bypass damaged DNA
9. TGen-Asuragen partner to advance pancreatic cancer research
10. The Atmosphere Research Group evaluates dynamic atmosphere in Mediterranean
11. Congress takes another stride toward public access to research
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Research pinpoints action of protein linked to key molecular switch
(Date:5/9/2016)... 2016 Elevay is currently known ... freedom for high net worth professionals seeking travel for ... connected world, there is still no substitute for a ... sealing your deal with a firm handshake. This is ... advantage of citizenship via investment programs like those offered ...
(Date:4/28/2016)... BANGALORE, India , April 28, 2016 ... of Infosys (NYSE: INFY ), and Samsung SDS, ... partnership that will provide end customers with a more ... payment services.      (Logo: http://photos.prnewswire.com/prnh/20130122/589162 ) ... financial services, but it also plays a fundamental part in ...
(Date:4/26/2016)... and LONDON , April 26, ... of EdgeVerve Systems, a product subsidiary of Infosys ... announced a partnership to integrate the Onegini mobile ...      (Logo: http://photos.prnewswire.com/prnh/20151104/283829LOGO ) ... customers enhanced security to access and transact across ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... June 23, 2016  Blueprint Bio, a company dedicated ... the medical community, has closed its Series A funding ... . "We have received a commitment from ... we need to meet our current goals," stated ... the runway to complete validation on the current projects ...
(Date:6/23/2016)... Francisco, CA (PRWEB) , ... June 23, 2016 ... ... (EDC) software, is exhibiting at the Pennsylvania Convention Center and will showcase its ... Annual conference. ClinCapture will also be presenting a scientific poster on Disrupting Clinical ...
(Date:6/23/2016)... 2016  Amgen (NASDAQ: AMGN ) today ... life sciences incubator to accelerate the development of ... space at QB3@953 was created to help high-potential life ... many early stage organizations - access to laboratory infrastructure. ... launched two "Amgen Golden Ticket" awards, providing each winner ...
(Date:6/22/2016)... Research and Markets has announced the addition ... their offering. The global ... billion in 2013. The market is expected to grow at a ... 2020, increasing from $50.6 billion in 2015 to $96.6 billion in ... forecast period (2015 to 2020) are discussed. As well, new products ...
Breaking Biology Technology: