Navigation Links
Research pinpoints action of protein linked to key molecular switch
Date:4/19/2010

Chapel Hill, NC Rho proteins have been described as "molecular switches" and play a role in cell migration, cell proliferation, cell death, gene expression, and multiple other common cellular functions.

Understanding the actions of Rho proteins is important to illuminating cellular mechanisms related to cancer, which is fundamentally a disease of cell misbehavior. When cells multiply too rapidly, multiply and migrate into inappropriate places in the body, do not die after their natural lifespan or create networks of blood vessels where they should not, cancer results.

A study led by Keith Burridge, PhD, professor of cell and developmental biology, published online April 18 in the journal Nature Cell Biology, demonstrates that a protein called Rho GDI1 is a key to maintaining a balance of Rho proteins that allow optimal cellular functioning.

Traditionally scientists have understood the regulation of these proteins to be a function of "on" or "off" switching and that Rho GDI was a passive player in this process. This study demonstrates that the mechanism is more subtle, like a dimmer switch on a lighting panel that allows for a spectrum of levels. Rho proteins are inherently unstable because they are partially made up of a lipid (or fat). RhoGDI contains a "pocket" that can bind this lipid, thus protecting it.

One of the most important findings from this study is that changes in the expression level of one Rho protein can affect the expression levels and activities of other members of the family. In cells there is a limited amount of RhoGDI, and many different Rho proteins compete for binding to RhoGDI. The authors show that, when the protein levels of a particular Rho protein are artificially increased, the other Rho proteins are displaced from RhoGDI and degraded. Notably, previous studies have shown that many cancers exhibit altered levels of Rho proteins, raising the possibility that RhoGDI may be playing an important role in the biology of these cancer cells.

The authors hope that their work will help scientists better understand the subtle balancing mechanism that keeps cells functioning optimally, eventually leading to therapies that might target the balance of these proteins to prevent the cellular misbehavior that leads to cancers. The authors present preliminary results with two different cancer cell lines showing a correlation between the expression levels of RhoGDI and the levels and activities of Rho proteins.


'/>"/>

Contact: Ellen de Graffenreid
edegraff@med.unc.edu
919-962-3405
University of North Carolina School of Medicine
Source:Eurekalert  

Related biology news :

1. Researchers identify new gene involved in the development of liver cancer
2. Volcanic ash research shows how plumes end up in the jet stream
3. UMCES fisheries biologist Dr. David Secor receives USM Regents Faculty Award for research
4. UC Riverside entomologist recognized for research in citrus entomology
5. NIDCD-funded chemosensory researchers present findings at AChemS 2010 Meeting
6. Cancer health disparities research highlighted at AACR 101st Annual Meeting 2010
7. Advocates and researchers educate community about cancer in game show format
8. UDs Zhuang wins NSF Early Career Award for research on how cells bypass damaged DNA
9. TGen-Asuragen partner to advance pancreatic cancer research
10. The Atmosphere Research Group evaluates dynamic atmosphere in Mediterranean
11. Congress takes another stride toward public access to research
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Research pinpoints action of protein linked to key molecular switch
(Date:5/16/2017)... , May 16, 2017  Veratad Technologies, LLC ( ... online age and identity verification solutions, announced today they ... Conference 2017, May 15 thru May 17, 2017, in ... and International Trade Center. Identity impacts ... and in today,s quickly evolving digital world, defining identity ...
(Date:4/19/2017)... New York , April 19, 2017 ... competitive, as its vendor landscape is marked by the ... the market is however held by five major players ... Safran. Together these companies accounted for nearly 61% of ... of the leading companies in the global military biometrics ...
(Date:4/13/2017)... According to a new market research report "Consumer IAM Market ... Authorization), Service, Authentication Type, Deployment Mode, Vertical, and Region - Global Forecast ... from USD 14.30 Billion in 2017 to USD 31.75 Billion by 2022, ... ... MarketsandMarkets Logo ...
Breaking Biology News(10 mins):
(Date:7/20/2017)... ... July 20, 2017 , ... Dr. Asher Kimchi, Founder and Chairman of ... 2017 IAC Awards at the 22nd World Congress on Heart Disease held in Vancouver, ... to receive the Distinguished Fellowship Awards. , Dr. Asher Kimchi, together with Co-Chairmen Dr. ...
(Date:7/20/2017)... and PLYMOUTH, Minn., July 20, 2017   ... a personalized genetic evaluations company, today announced that ... partnership investigating a genetic mutation implicated in KCNQ2 ... the partnership for a second case involving an ... the KCNQ2 Cure Alliance and Pairnomix entered into ...
(Date:7/18/2017)... (PRWEB) , ... July 18, 2017 , ... Sourcing custom ... with your needs and has the capabilities to properly execute your job can take ... customglassparts.com is a sourcing portal designed to showcase the company’s capabilities and ...
(Date:7/18/2017)... , ... July 18, 2017 , ... ... Framework, and has released the first phase of the Allotrope Framework for commercial ... Practices Awards were created to “not only elevate the critical role of information ...
Breaking Biology Technology: