Navigation Links
Research may lead to reliable alternative to open-heart surgery
Date:8/12/2014

HOUSTON, Aug. 12, 2014 University of Houston (UH) professor Suncica "Sunny" Canic is a mathematician, not a medical doctor, but her research could save the lives of heart patients. Working with collaborators from Houston Methodist Hospital on a minimally invasive experimental procedure for heart valve replacement, Canic's work could lead to optimal design of an alternative to open-heart surgery for treating failing heart valves.

"It almost sounds like science fiction," Canic said. "Our project combines the most recent breakthroughs in technology, such as 3-D human organ printing, materials science, mathematics, scientific computations and cardiovascular sciences."

Specifically, together with Dr. Stephen Little, a cardiologist at Methodist, Canic is leading an interdisciplinary team to improve the treatment of dysfunctional heart valves. With the number of patients requiring valve replacement on the rise, Canic and her colleagues are working to design new strategies in a minimally invasive procedure called Transcatheter Valve Replacement (TVR). Their approach would minimize post-procedural complications and provide a safe alternative to open-heart surgery.

An emerging treatment for patients with failing valves, TVR entails implanting a prosthetic valve through the skin, using catheterization to forgo more invasive surgery. Going through the groin area, a catheter containing a replacement valve is guided to the location of the failing valve. Canic says the stent holding this bioartificial valve is made of a shape memory alloy that assumes a predefined shape optimized for TVR procedures once it reaches the patient's body temperature of 98.6 degrees Fahrenheit. When the catheter reaches the location of the failing valve, the stent expands and anchors the bioartificial valve in place.

"Our computational results are being validated using functional, 3-D, patient-specific models in Dr. Little's lab. We are then testing them with virtual TVR procedures performed in an apparatus, called the pulsatile flow loop, at the Methodist DeBakey Heart and Vascular Center," Canic said. "By combining 3-D human organ printing and computational simulations of anatomic and physiologic conditions associated with TVR at this patient-specific level, the experimental and computational methods we're developing provide new information on the optimal design for this procedure."

Canic's research group at UH includes Hugh Roy and Lillie Cranz Cullen Professor of Mathematics Roland Glowinski, assistant professor Annalisa Quaini and several post-doctoral associates and graduate and undergraduate students. Her team is considered a leader in developing mathematical and computational techniques analyzing the interaction between fluids and structures, such as blood and cardiovascular tissue. The methodology they are developing is based on new computational approaches for providing stable, computationally efficient algorithms for valve motion, coupled with a novel approach to endovascular stent modeling.

Recognized as one of the leading experts in the world in the area of mathematical modeling and scientific computing related to cardiovascular science, Canic recently was honored at the 2014 Society of Industry and Applied Mathematics (SIAM) Annual Meeting held in July. Canic, a Cullen Distinguished Professor in the Department of Mathematics, was named to the 2014 SIAM Class of Fellows for her outstanding contributions to the development of mathematical theory and applications to the life sciences. Her interdisciplinary approach to studying TVR promises to provide a major breakthrough in the treatment and imaging of heart valve repair.


'/>"/>

Contact: Lisa Merkl
lkmerkl@uh.edu
713-743-8192
University of Houston
Source:Eurekalert  

Related biology news :

1. Study by UC Santa Barbara researchers suggests that bacteria communicate by touch
2. Research reveals first evidence of hunting by prehistoric Ohioans
3. Diabetes Research Institute develops oxygen-generating biomaterial
4. APS issues new policy requiring identification of sex or gender in reporting scientific research
5. UC Santa Barbara researchers discover genetic link between visual pathways of hydras and humans
6. Study jointly led by UCSB researcher supports theory of extraterrestrial impact
7. U of Alberta researcher steps closer to understand autoimmune diseases
8. Research on flavanols and procyanidins provides new insights into how these phytonutrients may positively impact human health
9. A project to research biological and chemical aspects of microalgae to fuel approach
10. Scripps Research discoveries lead to newly approved drug for infant respiratory distress syndrome
11. Researchers attempt to solve problems of antibiotic resistance and bee deaths in one
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Research may lead to reliable alternative to open-heart surgery
(Date:5/22/2019)... , ... May 22, 2019 , ... ... helium-based leak testing instruments for the Pharmaceutical, Biotechnology, Medical Device and ... agreement with Industrial Production Processes (IPP) Ltd has been signed. The ...
(Date:5/21/2019)... ... May 21, 2019 , ... Zer0 to ... 20 today, and to celebrate launched a new startup package, 0to5 Launch, to ... need – pre-product – to attract talent and investors. , “We launched our ...
(Date:5/21/2019)... ... May 21, 2019 , ... At their May 16 meeting, the members of ... (TEMPs) of the American Society for Testing and Materials International voted unanimously ... was the next step in the company’s plan to establish its AlphaSTEM Test™ ...
Breaking Biology News(10 mins):
(Date:5/14/2019)... EGG HARBOR TOWNSHIP, N.J. (PRWEB) , ... May ... ... premier manufacturer of custom built, helium-based leak testing instruments for the Pharmaceutical, Biotechnology, ... a completely new Heliumleak.com company website. The redesigned website aims to improve LDA’s ...
(Date:5/4/2019)... ... May 03, 2019 , ... Diopsys Inc, the ... ffERG/Photopic Negative Response vision test, a new full field electroretinography (ffERG) protocol ... that 6.3 million Americans will have glaucoma, with black Americans having the highest ...
(Date:5/2/2019)... ... May 02, 2019 , ... ... the greater Boston area. Gone are the days of painful hair transplant procedures. ... Hair Restoration System is the only robotic intelligent solution to offer a minimally ...
(Date:4/16/2019)... SAN ANTONIO (PRWEB) , ... April 16, 2019 ... ... biometrics-based human identification systems, applications, and technology, today announced that Bank South Pacific ... through a competitive RFP process. The bank awarded Fulcrum a contract to deliver ...
Breaking Biology Technology: