Navigation Links
Research links telomere length to emphysema risk
Date:7/14/2011

Telomeres, the body's own cellular clocks, may be a crucial factor underlying the development of emphysema, according to research from Johns Hopkins University.

"We found that in mice that have short telomeres, there was a significant increased risk of developing emphysema after exposure to cigarette smoke," said Mary Armanios, MD, assistant professor of oncology at the Johns Hopkins School of Medicine.

The study appears online ahead of the print edition of the American Journal of Respiratory and Critical Care Medicine.

Telomeres are DNA protein structures that protect chromosome ends from degradation. Their length is genetically determined, but they also shorten progressively with cell division. Short telomeres are considered one marker of ageing in cells.

"With age, short telomeres accumulate and cause cells to stop dividing. Telomeres can be thought of as 'biological clocks,'" Dr. Armanios explained. "We wanted to determine whether telomere length itself was why susceptibility to emphysema increases with age."

Dr. Armanios and her colleagues examined the role of telomeres in lung disease by studying mice that have shortened telomeres. The mice were exposed to cigarette smoke for six hours a day, five days a week for six months.

The researchers then analyzed the lung tissue and pulmonary function of the mice. "Although the mice had no lung disease at baseline, after exposure to cigarette smoke, they surprisingly developed emphysema. In contrast, mice with long telomeres did not develop lung disease during our experiments," said Dr. Armanios.

In emphysema, alveoli, the small air sacs where oxygen exchange occurs, are permanently lost. Emphysema changes are normally found in older individuals, and occasionally even in those who have never smoked. But they are most commonly found in smokers.

Emphysema is a common cause of disability, and among the top 10 causes of mortality in the
'/>"/>

Contact: Keely Savoie
ksavoie@thoracic.org
212-315-8620
American Thoracic Society
Source:Eurekalert

Page: 1 2

Related biology news :

1. Wistar Institute researcher receives New Innovator award from NIH
2. NC State researchers get to root of parasite genome
3. White Mountain Research Station to host climate change conference
4. Stevens awarded $1M for advanced biofuels research
5. Researchers find animal with ability to survive climate change
6. Researchers find an essential gene for forming ears of corn
7. Researchers note differences between people and animals on calorie restriction
8. Researcher working on destruction of chemical weapons
9. Researchers study acoustic communication in deep-sea fish
10. Researchers discover that growing up too fast may mean dying young in honey bees
11. The Rett Syndrome Research Trust launches operations
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/10/2014)... NEW YORK , June 27, 2014 /PRNewswire/ ... against Provectus Biopharmaceuticals, Inc. ("Provectus" or the "Company")(NYSE-MKT: ... action, filed in United States District Court, Middle ... Division, is on behalf of a class consisting ... otherwise acquired Provectus securities between December 17, 2013 ...
(Date:7/10/2014)... -- NXT-ID, Inc., (OTCQB: NXTD) a biometric authentication company focused on the ... was interviewed on July 1 st on the ... . Mr. Pereira discusses the company,s next generation smart wallet ... the Wocket™ aims to replace a traditional wallet with a ... tells Gino he has never heard of the Wocket ...
(Date:7/10/2014)... GOTHENBURG, Sweden , July 8, 2014 ... FPC1021 has won a new design win (DW). An Asian ... targeted date for mass production start in August 2014.   ... an Asian smartphone OEM, which has a planned date for ... received an initial ramp order of SEK 5M, for delivery ...
Breaking Biology News(10 mins):SHAREHOLDER ALERT: Pomerantz Law Firm Announces the Filing of a Class Action against Provectus Biopharmaceuticals, Inc. and Certain Officers - PVCT 2SHAREHOLDER ALERT: Pomerantz Law Firm Announces the Filing of a Class Action against Provectus Biopharmaceuticals, Inc. and Certain Officers - PVCT 3Security and Your Money: Tampa Bay Radio Host Cedric Harris Talks to NXT-ID CEO Mr. Gino Pereira about the Wocket Smart Wallet 2Security and Your Money: Tampa Bay Radio Host Cedric Harris Talks to NXT-ID CEO Mr. Gino Pereira about the Wocket Smart Wallet 3Security and Your Money: Tampa Bay Radio Host Cedric Harris Talks to NXT-ID CEO Mr. Gino Pereira about the Wocket Smart Wallet 4FPC Wins DW and Initial Ramp Order for FPC1021 Touch Sensor for Flagship Smartphone from Asian OEM 2
... biology textbooks, a single genetic mutation is rarely enough to ... a series of mutations that work together to trigger tumor ... that distinct cancer-causing mutations in neighboring cells can cooperate to ... Cancer biologists have long known that it takes ...
... , CARDIFF, Calif. , Jan. 13 ... Mind, Inc. was in high demand at this year,s Consumer Electronics Show ... many interviews with major media organizations during the 3 day event. Among ... Up TV , with Mark Albertson . Additionally, we have been ...
... Cold Spring Harbor, N.Y. Two scientists from ... international team that has discovered a genetic mutation that ... is a devastating inherited neurological disease that is very ... often among Ashkenazi Jews. The study was ...
Cached Biology News:Mutations in different cells cooperate to set the stage for cancer 2Mutations in different cells cooperate to set the stage for cancer 3Jedi Mind Receives Vast Media Coverage at CES in Las Vegas 2Jedi Mind Receives Vast Media Coverage at CES in Las Vegas 3CSHL scientists use next-gen sequencing to rapidly discover genetic cause of devastating disorder 2
(Date:7/10/2014)... researchers at the University of Illinois at Urbana-Champaign ... the interplay of spin and heat at the ... spintronic devices for data storage and information processing. ... as spin-angular momentum. In a typical charge current, ... spin current," explained David Cahill, a professor of ...
(Date:1/15/2014)... approach akin to assembling a club sandwich at ... (NIST) researchers have succeeded in crafting a uniform, ... of foam commonly used in upholstered furniture and ... nanotube-coated polyurethane foam was reduced 35 percent compared ...
(Date:1/15/2014)... JOLIET, Ill. , Jan. 15, 2014  Bill Jacobs Automotive, ... , is teaming up with the Heartland Blood Center ... annual blood drive. The drive takes place Saturday, Jan. 18 ... a.m. - 2 p.m. (Photo: http://photos.prnewswire.com/prnh/20140115/MN46637 )  ...
(Date:1/15/2014)... FALLS, N.Y., Jan. 15, 2014   Niagara Thermal ... been selected by Buffalo BioBlower Technologies LLC ("B3") as ... SBIR Phase 2 award from the Army Corps of ... system that kills all biological contaminants and destroys VOCs ...
Breaking Biology Technology:University of Illinois study advances limits for ultrafast nano-devices 2Layered security: Carbon nanotubes promise improved flame-resistant coating 2Join the Bill Jacobs Auto blood drive and receive a free oil change 2Niagara Thermal Products LLC Selected as Critical Supplier for Buffalo BioBlower Air Purification Systems 2
... can make a professor lose his cool more than having ... for making a mistake are endless: a DVD made specifically ... skipping around uncontrollably or even an overhead projector falling to ... duty of solving such technical issues and more falls on ...
... Madison, Wis. - If wireless keeps growing at its ... get their work done, says a wireless channel manager for ... at a recent Accelerate Madison program, saying the ... for corporations over the next few years. With costs falling ...
... Eau Claire, Wis . Faculty in the chemistry ... more than $600,000 in grant money from the National ... help them purchase state-of-the-art instrumentation and support faculty-student research. ... a department like ours and it'll have a significant ...
Cached Biology Technology:Interest drives investment of instructional technology 2Interest drives investment of instructional technology 3Interest drives investment of instructional technology 4Cisco manager touts wireless advantages 2UW-Eau Claire chemistry faculty get $600,000 in NSF grants 2UW-Eau Claire chemistry faculty get $600,000 in NSF grants 3
This antibody is specific for human J-chain as defined by ELISA assay using purified human immunoglobulin fragments as solid phase target antigen....
Tissue-Stat ( Tissue Adherent for Mounting Formalin-Fixed and Frozen Tissue Sections.)...
Clarin Mounting Medium (Permanent environmentally safe mounting medium for general histology & cytology use)...
IHC Zinc Fixative - , 1000 ml Consult technical datasheet for details....
Biology Products: