Navigation Links
Research links evolution of fins and limbs with that of gills
Date:3/23/2009

The genetic toolkit that animals use to build fins and limbs is the same genetic toolkit that controls the development of part of the gill skeleton in sharks, according to research to be published in Proceedings of the National Academy of Sciences on March 23, 2009, by Andrew Gillis and Neil Shubin of the University of Chicago, and Randall Dahn of Mount Desert Island Biological Laboratory.

"In fact, the skeleton of any appendage off the body of an animal is probably patterned by the developmental genetic program that we have traced back to formation of gills in sharks," said Andrew Gillis, lead author of the paper and a graduate student in the Department of Organismal Biology and Anatomy at the University of Chicago. "We have pushed back the evolutionary origin of the developmental genetic program that patterns fins and limbs."

This new finding is consistent with an old theory, often discounted in science textbooks, that fins and (later) limbs evolved from the gills of an extinct vertebrate, Gillis added. "A dearth of fossils prevents us from definitely concluding that fins evolved from gills. Nevertheless, this research shows that the genetic architecture of gills, fins and limbs is the same."

The research builds on the breakthrough discovery of the fossil Tiktaalik, a "fish with legs," by Neil Shubin and his colleagues in 2006. "This is another example of how evolution uses common developmental programs to pattern different anatomical structures," said Shubin, who is the senior author on the PNAS paper and Professor and Associate Dean of Organismal and Evolutionary Biology at the University of Chicago. "In this case, shared developmental mechanisms pattern the skeletons of vertebrate gill arches and paired fins."

The research also showed for the first time that the gill arch skeleton of embryonic skates (a living relative of sharks that has gill rays) responds to treatment with the vitamin A derivative retinoic acid in the same way a limb or fin skeleton does: by making a mirror image duplicate of the structure as the embryo develops. According to the researchers, the genetic circuitry that patterns paired appendages (arms, legs and fins) has a deep evolutionary origin that actually predates the origin of paired appendages themselves.

"These findings suggest that when paired appendages appeared, the mechanism used to pattern the skeleton was co-opted from the gills," Gillis said. "Perhaps we should think of shark gills as another type of vertebrate appendageone that's patterned in essentially the same way as fins and limbs."

The deep structural, functional, and regulatory similarities between paired appendages and developing gill rays, as well as the antiquity of gills relative to paired appendages, suggest that the signaling network that is induced by retinoic acid had a patterning function in gills before the origin of vertebrate appendages, the research concludes. And this function has been retained in the gill rays of living cartilaginous fishes.


'/>"/>

Contact: Greg Borzo
greg.borzo@uchospitals.edu
773-702-0892
University of Chicago Medical Center
Source:Eurekalert  

Related biology news :

1. Rensselaer receives more than $2 million from New York State to fund stem cell research
2. Review of probiotic trial research finds only Bifantis able to claim efficacy for IBS symptoms
3. Innerscope Research(R) Appoints Digital Leader, Andre Marquis, as Senior Vice President of Sales and Marketing
4. Innerscope Research(R) Uses Same-Day Results From Biometric Study to Identify Key Themes, Styles Behind Effective, Engaging Speaker Presentations
5. NIH funds research center for womens reproductive health at Einstein
6. Research to secure a safe water supply
7. Research synthesis shines light on several management options after fires in diverse ecosystems
8. Lombardi research: Monoclonal antibodies primed to become potent immune weapons against cancer
9. UK researcher identifies just 8 patterns as the cause of all humor
10. Pitt-led researchers create quick, simple fluorescent detector for TB
11. Einstein and Pitt researchers develop new TB test that will dramatically cut diagnosis time
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Research links evolution of fins and limbs with that of gills
(Date:4/19/2016)... -- The new GEZE SecuLogic access control ... system solution for all door components. It can be ... interface with integration authorization management system, and thus fulfills ... dimensions of the access control and the optimum integration ... considerable freedom of design with regard to the doors. ...
(Date:3/31/2016)... BOCA RATON, Florida , March 31, 2016 /PRNewswire/ ... LEGX ) ("LegacyXChange" or the "Company") ... presentation for potential users of its soon to be ... The video ( https://www.youtube.com/channel/UCyTLBzmZogV1y2D6bDkBX5g ) will also ... by the use of DNA technology to an industry ...
(Date:3/22/2016)... OTTAWA, Ontario , PROVO ... 2016 Newborn Screening Ontario (NSO), which operates ... for molecular testing, and Tute Genomics and ... process management technology respectively, today announced the launch of ... new next-generation sequencing (NGS) testing panel. ...
Breaking Biology News(10 mins):
(Date:5/23/2016)... ... May 23, 2016 , ... ... and services based in Aurora, Ohio, has broken ground on a new building ... Research Triangle Park area, this new location solidifies a commitment to business in ...
(Date:5/20/2016)... ... May 20, 2016 , ... The leading Regenerative Veterinary Medicine Company, ... veterinary clients have treated over 100 of their own patients with the VetStem Cell ... highest level of care for their patients. , The veterinarians are Dr Ross ...
(Date:5/20/2016)... ... ... The recent recall by Costco and Trader Joes of 47 million pounds ... 2016(1), demonstrates the need for faster and more cost effective bio-threat detection to ensure ... , PathSensor’s latest solution uses a biosensor technology called CANARY®. CANARY®, ...
(Date:5/19/2016)... 19, 2016 There is no ... given the relentless pressures in pricing and lack in ... investors circle though - numerous opportunities are up for ... session, ActiveWallSt.com,s presents four names in this sector: Portola ... Inc. (NASDAQ: VTAE ), Anthera Pharmaceuticals Inc. ...
Breaking Biology Technology: