Navigation Links
Research links evolution of fins and limbs with that of gills
Date:3/23/2009

The genetic toolkit that animals use to build fins and limbs is the same genetic toolkit that controls the development of part of the gill skeleton in sharks, according to research to be published in Proceedings of the National Academy of Sciences on March 23, 2009, by Andrew Gillis and Neil Shubin of the University of Chicago, and Randall Dahn of Mount Desert Island Biological Laboratory.

"In fact, the skeleton of any appendage off the body of an animal is probably patterned by the developmental genetic program that we have traced back to formation of gills in sharks," said Andrew Gillis, lead author of the paper and a graduate student in the Department of Organismal Biology and Anatomy at the University of Chicago. "We have pushed back the evolutionary origin of the developmental genetic program that patterns fins and limbs."

This new finding is consistent with an old theory, often discounted in science textbooks, that fins and (later) limbs evolved from the gills of an extinct vertebrate, Gillis added. "A dearth of fossils prevents us from definitely concluding that fins evolved from gills. Nevertheless, this research shows that the genetic architecture of gills, fins and limbs is the same."

The research builds on the breakthrough discovery of the fossil Tiktaalik, a "fish with legs," by Neil Shubin and his colleagues in 2006. "This is another example of how evolution uses common developmental programs to pattern different anatomical structures," said Shubin, who is the senior author on the PNAS paper and Professor and Associate Dean of Organismal and Evolutionary Biology at the University of Chicago. "In this case, shared developmental mechanisms pattern the skeletons of vertebrate gill arches and paired fins."

The research also showed for the first time that the gill arch skeleton of embryonic skates (a living relative of sharks that has gill rays) responds to treatment with the vitamin A derivative retinoic acid in the same way a limb or fin skeleton does: by making a mirror image duplicate of the structure as the embryo develops. According to the researchers, the genetic circuitry that patterns paired appendages (arms, legs and fins) has a deep evolutionary origin that actually predates the origin of paired appendages themselves.

"These findings suggest that when paired appendages appeared, the mechanism used to pattern the skeleton was co-opted from the gills," Gillis said. "Perhaps we should think of shark gills as another type of vertebrate appendageone that's patterned in essentially the same way as fins and limbs."

The deep structural, functional, and regulatory similarities between paired appendages and developing gill rays, as well as the antiquity of gills relative to paired appendages, suggest that the signaling network that is induced by retinoic acid had a patterning function in gills before the origin of vertebrate appendages, the research concludes. And this function has been retained in the gill rays of living cartilaginous fishes.


'/>"/>

Contact: Greg Borzo
greg.borzo@uchospitals.edu
773-702-0892
University of Chicago Medical Center
Source:Eurekalert  

Related biology news :

1. Rensselaer receives more than $2 million from New York State to fund stem cell research
2. Review of probiotic trial research finds only Bifantis able to claim efficacy for IBS symptoms
3. Innerscope Research(R) Appoints Digital Leader, Andre Marquis, as Senior Vice President of Sales and Marketing
4. Innerscope Research(R) Uses Same-Day Results From Biometric Study to Identify Key Themes, Styles Behind Effective, Engaging Speaker Presentations
5. NIH funds research center for womens reproductive health at Einstein
6. Research to secure a safe water supply
7. Research synthesis shines light on several management options after fires in diverse ecosystems
8. Lombardi research: Monoclonal antibodies primed to become potent immune weapons against cancer
9. UK researcher identifies just 8 patterns as the cause of all humor
10. Pitt-led researchers create quick, simple fluorescent detector for TB
11. Einstein and Pitt researchers develop new TB test that will dramatically cut diagnosis time
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Research links evolution of fins and limbs with that of gills
(Date:4/24/2017)... Janice Kephart , former 9/11 ... Partners, LLP (IdSP) , today issues the following ... March 6, 2017 Executive Order: Protecting the ... be instilled with greater confidence, enabling the reactivation ... applications are suspended by until at least July ...
(Date:4/17/2017)... , April 17, 2017 NXT-ID, Inc. ... company, announces the filing of its 2016 Annual Report on Form ... Exchange Commission. ... Form 10-K is available in the Investor Relations section of the ... on the SEC,s website at http://www.sec.gov . 2016 ...
(Date:4/11/2017)... April 11, 2017 Crossmatch®, a globally-recognized ... solutions, today announced that it has been awarded ... Projects Activity (IARPA) to develop next-generation Presentation Attack ... "Innovation has been a driving force within ... will allow us to innovate and develop new ...
Breaking Biology News(10 mins):
(Date:5/26/2017)... ... May 25, 2017 , ... ... process behind each occurrence. Live cell imaging using fluorescence microscopy is the perfect ... of automated fluorescence microscopy methods will be discussed, from small animal models and ...
(Date:5/24/2017)... ... May 23, 2017 , ... Triumph ... modular buildings, announced the launch of the Mobile Big Room. This state-of-the-art ... help support on-site teamwork and collaboration. , The Mobile Big Room enables ...
(Date:5/23/2017)... ... May 23, 2017 , ... Firmex today announced ... it easy for organizations to send and gather large files and confidential documents ... email file size limitations. , Using the same market-tested infrastructure as Firmex’s ...
(Date:5/23/2017)... Hong Kong (PRWEB) , ... May 22, 2017 ... ... the third year in a row in the Aragon Research Globe™ for Corporate ... that align with industry direction and market demand, and effectively perform against those ...
Breaking Biology Technology: