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Research links 29 genome regions with common form of inflammatory bowel disease
Date:2/6/2011

e system responds to the natural bacteria found in the gut could be an important part of the disease profile of inflammatory bowel disease.

The researchers suggest that the candidate genes including several key members of the 'IL23 pathway' could provide good targets for researchers developing therapeutic interventions against the disease.

As well as finding genes that point towards a shared biology the researchers also found evidence of genetic events that might be unique to ulcerative colitis.

"For many patients, ulcerative colitis means a lifetime of bloody diarrhoea and stomach pains," says Dr. John Rioux. "The disease can be very severe in some patients resulting in life-threatening inflammation of the large bowel, and there is an increased risk of developing bowel cancer. This is a really unpleasant and intrusive illness that typically affects young adults, and for which we presently have no known cure. "

"We have some good medical therapies, but for many patients these are either not effective or poorly tolerated. We therefore have an urgent unmet therapeutic need and it is my great hope that we can translate our really exciting genetic findings into effective new therapies in the next five to ten years, " said Dr. John Rioux.

The new findings open the door for further research to explore the candidate genes identified and their possible role in the development of the ulcerative colitis and inflammatory bowel disease.


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Contact: William Raillant-Clark
w.raillant-clark@umontreal.ca
514-343-7593
University of Montreal
Source:Eurekalert

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