Navigation Links
Research links 29 genome regions with common form of inflammatory bowel disease
Date:2/6/2011

An international team of researchers has made new links between 29 regions of the genome and ulcerative colitis a common form of inflammatory bowel disease (IBD). The new findings increase the total number of genome regions known to be associated with inflammatory bowel disease to 99.

The results point to several biological processes, including the way that our bodies maintain the lining of the intestinal wall, which are likely to play an important role in the development of ulcerative colitis.

The causes of inflammatory bowel disease are not fully understood, although it is thought that patients with inflammatory bowel disease have an overactive immune response against typical gut contents. Together, ulcerative colitis and Crohn's disease the two primary causes of inflammatory bowel disease affect one in 250 people in Europe, North America and Australasia.

Unlike Crohn's disease, which can impair any part of the human digestive tract, ulcerative colitis is restricted to the large bowel. Up to 20 per cent of ulcerative colitis patients will require surgery to remove the entire large bowel.

"The outcomes and quality of life for patients with ulcerative colitis can be bleak", says Dr. John Rioux, from the Montreal Heart Institute and the Universit de Montral, senior author on the paper, and co-chair of the International IBD Genetics Consortium. "To understand the genetic causes of the disease, we carried out the largest study of the disease to date taking a magnifying glass to over one million sites in the genomes of more than 26,000 people."

"Ultimately, we hope that unmasking the genetic processes that give rise to the disease will minimise the need for surgical outcomes, by opening the door for new therapies that can stop the disease in its tracks."

"With one in 160 Canadians living with either Crohn's disease or ulcerative colitis, we have among the highest rates of IBD in the world," says Dr. Kevin G
'/>"/>

Contact: William Raillant-Clark
w.raillant-clark@umontreal.ca
514-343-7593
University of Montreal
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Just in time for Valentines Day: UNC researchers identify a gene critical for heart function
2. Johns Hopkins researchers capture jumping genes
3. The brain knows what the nose smells, but how? Stanford researchers trace the answer
4. Scientific research reveals brain alterations linking omega 3 deficit with depression
5. Arctic fisheries catches 75 times higher than previous reports: UBC research
6. Cornell researchers find a strong community protects adolescents from risky health behavior
7. Scientists urge new research policies in wake of Gulf disaster
8. First new C. difficile drug in a generation superior to existing treatments: Researchers
9. State of the Union focuses on research, education and innovation
10. Damon Runyon-Rachleff Innovation Awards granted for pioneering ideas in cancer research
11. Researchers test inhalable measles vaccine
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/23/2014)... is a technique used to read quickly. It ... skipping non-essential words and/ or sentences. Similarly to ... to quickly "read" genetic information. Genes that need ... the smaller the encoding message, the easier it ... from Instituto Gulbenkian de Cincia (IGC, Portugal) and ...
(Date:4/22/2014)... of Yale researchers will lead a five-year, $3 million ... events is affecting the transport of dissolved organic matter ... say could alter the chemical composition and water quality ... funding from the National Science Foundation,s MacroSystems Biology program, ... the watershed, which begins in Canada and runs through ...
(Date:4/22/2014)... International Science Consortium Ltd.,s nanotechnology expert will present a ... hazard assessment" at the 7th International Nanotoxicology Congress ... Turkey. , Dr. Monita Sharma will outline a ... National Academy of Sciences, " Toxicity Testing in the ... recommends use of non-animal methods involving human cells and ...
Breaking Biology News(10 mins):Cell division speed influences gene architecture 2Connecticut River watershed study will assess impacts of extreme rain events 2Connecticut River watershed study will assess impacts of extreme rain events 3
... 2012 The Crop Science Society of America (CSSA) announces ... their Annual Meetings, Oct. 21-24, 2012 in Cincinnati, OH. Members ... achievements and meritorious service. Only 0.3 percent of the Society,s ... class of CSSA Fellows are: Marc C. Albertsen, ...
... biological cells like a skin. They also surround organelles ... division. Scientists have long known in principle how biomembranes ... a role in maintaining the optimal distance between neighboring ... with the help of computer simulations, scientists of the ...
... Bioluminescence may play a key role in successful foraging ... research published Aug. 29 in the open access journal ... led by Jade Vacqui-Garcia, monitored the diving behaviour of ... Ocean that were also equipped with light detectors. The ...
Cached Biology News:Crop Science Society of America presents 2012 class of fellows 2Crop Science Society of America presents 2012 class of fellows 3Keep your distance! Why cells and organelles don't get stuck 2
(Date:1/14/2014)... Date: Friday, April 11, 2014 , Time: 6 ... Almshouse Road, Warrington, Pa. , Details: The Hepatitis ... finding a cure for hepatitis B and improving the quality ... Crystal Ball on Friday, April 11 at Warrington Country Club ...
(Date:1/14/2014)... NY (PRWEB) January 14, 2014 EquitiesIQ, ... Alliqua, Inc. (OTCQB: ALQA). Alliqua is an emerging biomedical ... serve the wound care market. , Free report download: ... restructured with a seasoned management team and Board, which ...
(Date:1/14/2014)... , Jan. 14, 2014  RXi Pharmaceuticals Corporation (OTCQX: ... and commercializing innovative therapies addressing major unmet medical ... received the Notice of Allowance from the United ... self-delivering RNAi compounds (sd-rxRNA®), for the treatment of ...
(Date:1/14/2014)... Rochester, NY (PRWEB) January 14, 2014 During ... is now known as “The Doctor’s Plague.” In this time ... their hands. This led, at times, to the death of ... staff today don’t know that they may be unwittingly transmitting ...
Breaking Biology Technology:Hepatitis B Foundation to Host Annual Crystal Ball Gala 2EquitiesIQ Initiates Coverage of Alliqua, Inc. 2EquitiesIQ Initiates Coverage of Alliqua, Inc. 3RXi Pharmaceuticals Receives US Notice of Allowance for a Key Patent Relating to its Self-Delivering Technology with sd-rxRNAs targeting CTGF, including RXI-109, for the Treatment of Fibrotic Disorders 2RXi Pharmaceuticals Receives US Notice of Allowance for a Key Patent Relating to its Self-Delivering Technology with sd-rxRNAs targeting CTGF, including RXI-109, for the Treatment of Fibrotic Disorders 3Study: Fatigued Medical Interns Infect Their Patients with Herpes Viruses; The CBCD Sees a Parallel with “The Doctor’s Plague” 2Study: Fatigued Medical Interns Infect Their Patients with Herpes Viruses; The CBCD Sees a Parallel with “The Doctor’s Plague” 3
... EASTON, Mass., March 6 Pressure,BioSciences, Inc. (Nasdaq: ... teleconference to discuss its 2007 financial results and to ... teleconference either,by telephone or through a live web-cast. The ... March 12, 2008, Time: 4:30 p.m. Eastern Daylight ...
... to Support European Partnerships, ALAMEDA, Calif., and ... collaboration with Novartis Pharma AG to give Novartis,access ... Technology Access Program (ETAP). Terms of the collaboration,were ... opening of a,facility in Paris, France to support ...
... Recently the State of,Brandenburg, and the EU, ... Alcat Europe, GmbH, covering marketing and employee costs ... laboratory company located in the BioTech Park in,Hennigsdorf ... food and,chemical sensitivities through the Alcat test method. ...
Cached Biology Technology:Pressure BioSciences, Inc. to Discuss 2007 Financial Results and Provide Business Update 2Singulex Collaborates With Large Pharmaceutical Company in Erenna(TM) Technology Access Program 2European Union, State of Brandenburg, Award Grants to Alcat Europe, GmbH 2
... Sequencer 20 System revolutionizes DNA sequencing, delivering ... The Genome Sequencer 20 System includes: ... and consumables for library construction, amplification, and ... de novo assembly The ...
... The RapidVUE is a particle shape and ... has been designed with the utmost simplicity in ... sample delivery module and an optical bench. The ... allows for easy upgrade for different applications such ...
... The ProteoSpin Detergent Clean-up Micro Kit provides ... removal of SDS, Triton X-100 and other detergents ... spin-column chromatography using Norgens patented protein resin as ... processing 2 50 g of either acidic or ...
... degradation is critical to the maintenance ... regulatory proteins as important and diverse ... heat shock and stress response, antigen ... and ion channels, cell cycle regulation, ...
Biology Products: