Navigation Links
Research identifies mechanism responsible for eye movement disorder
Date:8/21/2012

A research team from King's College London and the University of Exeter Medical School has identified how a genetic mutation acts during the development of nerves responsible for controlling eye muscles, resulting in movement disorders such as Duane Syndrome, a form of squint.

The findings could provide the key to reversing the condition and unlocking the causes of movement disorders in other parts of the body.

The research is published in Proceedings of the National Academy of Sciences.

As nerves develop in the womb they respond to signals that tell them in which direction to grow. Some signals encourage them to grow to a particular part of the body, while other signals tell them to avoid certain areas.

When the system works as it should, the right type of nerve grows to the appropriate part of the body.

The surface of growing nerves includes identification receptors that respond to signals from secreted proteins. The protein mutated in Duane Syndrome acts as a switch that weighs up incoming signals from the receptors in this way the nerve knows whether it must grow towards a part of the body or be repulsed away.

In conditions such as Duane Syndrome, the signalling breaks down and the nerve cells are unable to distinguish between a signal of attraction or repulsion. As a result, the nerves that control eye movements grow to the wrong muscles causing limited or complete loss of eye movement. If not corrected surgically, this can lead to partial blindness in later life.

This recent research has provided new insights into how this 'switch signal' system works and how it has failed in cases of Duane Syndrome, causing the 'wiring up' of the wrong muscle or 'overshooting' of nerve development past the correct muscle.

The findings are likely to lead to further study which will identify how the 'switch signal' mechanism could be harnessed to selectively change nerve cell development beha
'/>"/>

Contact: Andrew Gould
andrew.gould@pcmd.ac.uk
44-188-438-346
The Peninsula College of Medicine and Dentistry
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Study by UC Santa Barbara researchers suggests that bacteria communicate by touch
2. Research reveals first evidence of hunting by prehistoric Ohioans
3. Diabetes Research Institute develops oxygen-generating biomaterial
4. APS issues new policy requiring identification of sex or gender in reporting scientific research
5. UC Santa Barbara researchers discover genetic link between visual pathways of hydras and humans
6. Study jointly led by UCSB researcher supports theory of extraterrestrial impact
7. U of Alberta researcher steps closer to understand autoimmune diseases
8. Research on flavanols and procyanidins provides new insights into how these phytonutrients may positively impact human health
9. A project to research biological and chemical aspects of microalgae to fuel approach
10. Scripps Research discoveries lead to newly approved drug for infant respiratory distress syndrome
11. Researchers attempt to solve problems of antibiotic resistance and bee deaths in one
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/31/2015)... 2015 BGI llevará a cabo la 10ª Conferencia ... 25 de octubre de 2015, en Shenzhen, ... décimo aniversario este año. Desde su inauguración en 2006, ... anuales más influyentes del mundo en los campos de ... más dinámicas, entusiastas y amenas. ICG-10 se ...
(Date:7/31/2015)... La 10 th International Conference on Genomics ... 22 al 25 de octubre de 2015 en ... conferencia celebra su décimo aniversario. Desde su inauguración en el ... reuniones anuales más influyentes del mundo en el campo ,ómico, ... y mejores a nivel científico. ICG-10 se ...
(Date:7/31/2015)... The 10 th International Conference on Genomics ... 22-25, 2015, in Shenzhen , ... 10 th anniversary this year. Since its inauguration in ... annual meetings in the ,omics, fields, and is one of ... ICG-10 focuses on recent breakthroughs and advances in ,omics, ...
Breaking Biology News(10 mins):La 10ª Conferencia Internacional sobre Genómica (ICG-10) comienza en octubre 2La 10ª Conferencia Internacional sobre Genómica (ICG-10) comienza en octubre 3La 10th International Conference on Genomics (ICG-10) se llevará a cabo en octubre 2La 10th International Conference on Genomics (ICG-10) se llevará a cabo en octubre 3The 10th International Conference on Genomics (ICG-10) to Open in October 2
... Whether or not a fertilized mammalian egg ultimately develops into ... a tug of war between two different genes encoding signaling ... new study led by Duke University Medical Center cell biologists. ... two specific genes, Wnt4 and Fgf9, are in equal balance ...
... entire superfamily of nuclear receptors ?proteins that turn genes ... Center researchers found that certain receptors form networks and ... main areas, reproduction and nutrient metabolism. , Receptor networks ... found. , The findings, published today in two studies ...
... human subjects to operate a robot-controlled joystick, Johns Hopkins researchers ... certain muscle movements, the more likely it is to remember ... say, could alter rehabilitation approaches for people who have lost ... a report on the work in the May 23 issue ...
Cached Biology News:Genetic tug of war determines sexual differentiation 2Genetic tug of war determines sexual differentiation 3First 'encyclopedia' of nuclear receptors reveals organisms' focus on sex, food 2First 'encyclopedia' of nuclear receptors reveals organisms' focus on sex, food 3New approach to vaccine development provides potent, long-lasting immunity 2New approach to vaccine development provides potent, long-lasting immunity 3
(Date:8/3/2015)... , Aug. 3, 2015  MiMedx Group, Inc. ... utilizing human amniotic tissue and patent-protected processes to develop ... Care, Surgical, Orthopedic, Spine, Sports Medicine, Ophthalmic and Dental ... at the 35 th Annual Canaccord|Genuity Growth Conference ... "Pete" Petit, Chairman and CEO, William C. Taylor ...
(Date:8/3/2015)... 3, 2015 E-QURE Corp. (OTCQB: ... its Bio-electrical Signal Therapy device ("BST Device"), a new ... to heal chronic wounds, today announced that the Company ... Israeli distributor specializing in medical devices, for the marketing ... is a 70 years old, sales, marketing and distribution ...
(Date:7/31/2015)... , July 31, 2015 In ... resources that help them drive positive health outcomes, ... vital source of patient care in their communities. ... annual tradeshow and conference, AmerisourceBergen announced a new ... Pharmacy Services Administration Organization and help independent pharmacies ...
(Date:7/30/2015)... ATLANTA , July 30, 2015 ... leaders to the 2015 AACC Annual Meeting & ... from July 26–30. The meeting showcased revolutionary ... improves the ability of healthcare providers to diagnose ... get effective medical treatment. As ...
Breaking Biology Technology:MiMedx To Present At 35th Annual Canaccord|Genuity Growth Conference 2E-QURE Corp Signs Second Distribution Agreement in Israel 2E-QURE Corp Signs Second Distribution Agreement in Israel 3AmerisourceBergen Unveils Suite of Enhanced Capabilities for Independent Pharmacies at ThoughtSpot 2015 2AmerisourceBergen Unveils Suite of Enhanced Capabilities for Independent Pharmacies at ThoughtSpot 2015 3Innovative Research on Cancer, Heart Disease, and Infectious Diseases Draws More than 17,500 Attendees to 2015 AACC Annual Meeting 2Innovative Research on Cancer, Heart Disease, and Infectious Diseases Draws More than 17,500 Attendees to 2015 AACC Annual Meeting 3Innovative Research on Cancer, Heart Disease, and Infectious Diseases Draws More than 17,500 Attendees to 2015 AACC Annual Meeting 4
... CHENGDU, China, Sept. 16 /PRNewswire-Asia-FirstCall/ -- ... ), a manufacturer and supplier of,modernized traditional Chinese ... obtained the Good Manufacturing Practices Certificate for,pharmaceutical products ... ("SFDA") in China. , ...
... HOERSHOLM, Denmark and SAN DIEGO, California, September 16 ... A/S Appoints Leading RNA Industry Expert,Art Levin Ph.D. as President ... - Utilizing its Proprietary RNA Chemistry - Locked ... to Foster Relationships,With New Partners, Increase Visibility With Capital Markets ...
... Colorado and JERUSALEM, September 16 Children,s,Hospital of Colorado ... Hospital is enrolling patients for the ExCell study.,Children,s Hospital ... transplant sites,worldwide, five of which are children,s centers, participating ... Israel. The trial is researching the,safety and efficacy of ...
Cached Biology Technology:Tianyin Pharmaceutical Co., Inc. Obtains GMP Certification for Its New Production Facility 2Tianyin Pharmaceutical Co., Inc. Obtains GMP Certification for Its New Production Facility 3New Collaborations and Breakthrough Advancements in RNA-Based Drug Development Programs Lead Santaris Pharma A/S to Establish US Operations 2New Collaborations and Breakthrough Advancements in RNA-Based Drug Development Programs Lead Santaris Pharma A/S to Establish US Operations 3New Collaborations and Breakthrough Advancements in RNA-Based Drug Development Programs Lead Santaris Pharma A/S to Establish US Operations 4Children's Hospital in Colorado Rounds off List of 24 Cord Blood Transplant Centers Worldwide Enrolling for ExCell Trial Studying StemEx(R) for Leukemia and Lymphoma 2Children's Hospital in Colorado Rounds off List of 24 Cord Blood Transplant Centers Worldwide Enrolling for ExCell Trial Studying StemEx(R) for Leukemia and Lymphoma 3Children's Hospital in Colorado Rounds off List of 24 Cord Blood Transplant Centers Worldwide Enrolling for ExCell Trial Studying StemEx(R) for Leukemia and Lymphoma 4
Incomplete Adjuvant...
The ELISA Kit for Hepatitis B Surface Antigen (HBsAg) is an in vitro enzyme immunoassay for the detection of HBsAg in human serum or plasma....
HiTrap Streptavidin HP, 5 x 1 ml. Category: Chromatography Systems & Accessories, Systems....
IC50: 3 ng/ml · Limit of detection: 0.5 ng/ml...
Biology Products: