Navigation Links
Research identifies first method for testing, assessing drug treatments for Chagas' disease
Date:4/20/2008

Athens, Ga. Chagas disease is a tropical parasitic sickness that currently affects more than 16 million people, with a staggering 100 million at risk, largely in the tropical areas of South and Central America. And yet the main drug used to treat the disease is highly toxic and causes serious side effects.

Now, new research just published by scientists at the University of Georgia has identified for the first time a sensitive method for testing and assessing the efficacy of treatments for Chagas disease. The study could lead to new treatments for long-term sufferers of a disease that can be fatal.

It is the first time weve been able to identify a set of measurements to determine whether or not a drug for Chagas actually works, said Rick Tarleton, distinguished research professor of cellular biology and a faculty member at UGAs Center for Tropical and Emerging Global Diseases.

The research was published today in the online edition of the journal Nature Medicine. Co-authors, also from the University of Georgia, are postdoctoral associate Juan Bustamante and masters degree student Lisa Bixby.

The research presents the first and only evidence that the current drug therapies for Chagas disease can actually completely cure the infection. Still, current treatments have potentially severe side effects and are thought to be effective in less than 50 percent of those treated. More important, the model the team developed can be used for the development of better drugs against Trypanosoma cruzi, the parasite that causes the disease.

We also found that the immunological markers of cure in this system, which we developed in mice, provide a means to monitor drug treatment efficacy in humans, something that has been the biggest impediment to developing new drugs, said Tarleton.

Theres a fourth finding more important to the big picture of immunology, however. This study shows that chronic infections do not by default exh
'/>"/>

Contact: Kim Osborne
kosborne@uga.edu
706-583-0913
University of Georgia
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Research shows skeleton to be endocrine organ
2. Newly created cancer stem cells could aid breast cancer research
3. Dominant cholesterol-metabolism ideas challenged by new research
4. Researchers identify proteins involved in new neurodegenerative syndrome
5. Texas researchers and educators head for Antarctica
6. MGH researchers describe new way to identify, evolve novel enzymes
7. University of Pennsylvania researchers develop formula to gauge risk of disease clusters
8. University of Oregon researcher finds that on waters surface, nitric acid is not so tough
9. U of MN researchers discover noninvasive diagnostic tool for brain diseases
10. U of Minnesota researchers discover noninvasive diagnostic tool for brain diseases
11. Story ideas from the Journal of Lipid Research
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/17/2014)... serious conditions such as heart disease, epilepsy and pain, ... Unfortunately, there is still much scientists do not know ... unexpected insight into the structure of sodium channels and, ... which are responsible for ,fine-tuning, the activity of the ... edition of the Journal of Biological Chemistry . ...
(Date:4/17/2014)... expression is the process whereby the genetic information ... such as proteins, which have numerous different functions ... an important intermediary during gene expression, by relating ... mechanisms involved in manufacturing proteins. , By ... molecules present in an organism at a given ...
(Date:4/17/2014)... National University (ANU), have developed a new way ... over the past 5.3 million years., The findings ... ice ages over the past two million years, ... dioxide levels, global temperatures and sea levels., The ... and the National Oceanography Centre (NOC) in the ...
Breaking Biology News(10 mins):Structure of sodium channels different than previously believed 2Rapid and accurate mRNA detection in plant tissues 2Ancient sea-levels give new clues on ice ages 2
... D.C.Carnegie staff scientist Greg Asner has been elected to ... 84 new members and 21 foreign associates from 14 ... achievements in original research." The total number of active ... in 2001 as the Department of Global Ecology,s first ...
... plots in the Northeast and Midwestern United States contain at ... study found. The study across two dozen states from North ... the landscape where invasive plants might take root. "We ... forest inventory had at least one introduced species, but this ...
... for compounds related in composition to the active ingredient in ... published in the Journal of Leukocyte Biology ... (CB2) receptor in white blood cells, specifically macrophages, appear to ... link through which the pharmaceutical properties of cannabis are manifested. ...
Cached Biology News:Carnegie's Greg Asner elected to National Academy of Sciences 2In the Northeast, forests with entirely native flora are not the norm 2Synthetic derivatives of THC may weaken HIV-1 infection to enhance antiviral therapies 2
(Date:1/15/2014)... The Microcompetition with Foreign DNA theory explains how latent viruses ... is the Epstein Barr Virus (EBV), and one of these ... chronic inflammatory disease that destroys the body’s joints. As predicted ... high concentrations of EBV DNA in their bodies (1). ...
(Date:1/15/2014)... Scottsdale, Arizona (PRWEB) January 15, 2014 ... growth for Scottsdale’s Brain State Technologies®. They saw continued ... University Medical Center who were awarded a $1 million ... papers published in “Brain and Behavior” a peer reviewed ...
(Date:1/15/2014)... AudioNotch is the internet's leading provider of ... of tinnitus. Patients listen to sound therapy that is ... of weeks to months, their tinnitus volume decreases. , AudioNotch ... Music and Notched White Noise. Now, AudioNotch is pleased to ...
(Date:1/14/2014)... Doylestown, PA (PRWEB) January 14, 2014 Date: ... p.m. , Location: Warrington Country Club, 1360 Almshouse Road, Warrington, ... only national nonprofit organization solely dedicated to finding a cure ... those affected worldwide, will host its annual Crystal Ball on ...
Breaking Biology Technology:Study: Rheumatoid Arthritis (RA) Patients Have EBV; The CBCD Says this is Consistent with Microcompetition 2Study: Rheumatoid Arthritis (RA) Patients Have EBV; The CBCD Says this is Consistent with Microcompetition 3Dynamic Innovative Technology Showcased at Scottsdale Company’s Open House 2Dynamic Innovative Technology Showcased at Scottsdale Company’s Open House 3Hepatitis B Foundation to Host Annual Crystal Ball Gala 2
... Jonathan Stamler Has Authored A New Understanding Of Heart ... Therapeutics,Inc. (OTC Bulletin Board: DSKA) ("Duska") announced today that ... exclusive scientific consultant,to advise on the clinical development of ... Dr. Stamler is the George Barth Geller Professor ...
... today,announced that healthcare industry veteran John J. Arlotta ... was announced during the,most recent NOVIS Board of ... http://www.newscom.com/cgi-bin/prnh/20081023/CLTH043LOGO ), "I am very ... and I look forward to,helping the company achieve ...
... Oct. 23 LI-COR(R) Biosciences in,partnership with ... system to LI-COR,s small animal imaging platforms. ... components required to connect,to the Pearl Imager(TM) ... veterinarians, is simple to operate, works safely ...
Cached Biology Technology:Leading Heart Specialist Joins Duska Therapeutics as Scientific Consultant 2Leading Heart Specialist Joins Duska Therapeutics as Scientific Consultant 3Leading Heart Specialist Joins Duska Therapeutics as Scientific Consultant 4Leading Heart Specialist Joins Duska Therapeutics as Scientific Consultant 5NOVIS Announces Appointment of John J. Arlotta as Chairman 2LI-COR Biosciences and Euthanex Corporation Provide Anesthesia System for Small Animal Imaging 2
...
...
Collected from sexually matured, mixed breed, mixed sex guinea pigs....
Antibody specific for phosphorylattion of histone H3 that occurs during mitosis. Rabbit polyclonal serum. Antigen: Synthetic peptides derived from histone H3, phosphorylated at serines 10 or 28...
Biology Products: