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Research highlights from ICAAC meeting

would have resulted in modification of therapy for 13% of patients within 24 hours of positive blood culture. Routine implementation of MALDI-TOF analysis of blood culture samples could have a signficant impact on clinical management of this disease.

T Saluja, Sandwell and West Birmingham NHS Trust, Birmingham, United Kingdom

Poster Session 13, Paper D-113

Quick Identification with MALDI-TOF

Use of MALDI-TOF analysis directly on positive blood cultures signficantly reduced the time required to identify the causitive agent of blood stream infections, from 27 to 17 hours.

Katherine Bond, St Vincent's Hosp., Melbourne, Australia

Poster Session 13, Paper D-114

New Rapid Test for Antibiotic Resistance

A new test for extended spectrum betalactamase (ESBL) antibiotic-resistant bacteria can identify ESBL-resistant bacteria in blood cultures in 30 minutes compared to traditional tests which can take 24-48 hours.

Laurent Dortet, Hosp. de Bicetre, Le Kremlin Bicetre, France

Poster Session 13, Paper D-121(summary available)

New C. difficile Drug Candidate Does Not Disrupt Gut Flora

A study of the effects of a candidate drug for treatment of Clostridium difficile infection demonstrates that the drug causes only very modest changes in the normal gut flora with the exception of a signficant decrease in C. difficile.

Emma Best, Leeds Teaching Hosp. NHS Trust, Leeds, United Kingdom

Poster Session 18, Paper K-167

Actual Versus Ideal Body Weight: No Difference in Antibiotic Outcomes

Using an adjusted body weight (based on ideal body weight) instead of actual body weight to determine dosage of the antibiotic daptomycin for treatment of vancomycin-resistant enterococcal (VRE) bacteremia in obese patients resulted in similar clinical outcomes but cost $1,200 per patient less.

Jerod Nagel, Univ. of Michigan Hlth. Syst., Ann Arbor, MI, United States


Contact: Garth Hogan
American Society for Microbiology

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