Navigation Links
Research finds new cause of ozone wheezing and potential treatments
Date:2/3/2009

Researchers at the National Institute of Environmental Health Sciences (NIEHS), part of the National Institutes of Health, and Duke University have discovered a cause of airway irritation and wheezing after exposure to ozone, a common urban air pollutant. Using an animal model, the researchers were also able to identify several ways to stop the airways from narrowing. These findings help identify potential new targets for drugs which may eventually help physicians better treat emergency room patients suffering from wheezing, coughing and shortness of breath.

"We found that it is not the ozone itself that causes the body to wheeze, but the way the lungs respond to ozone," said Stavros Garantziotis, M.D., principal investigator in the NIEHS Laboratory of Respiratory Biology and lead author of the paper published online this week in the Journal of Biological Chemistry.

"Animals exposed to ozone produced and released high amounts of a sugar known as hyaluronan," said John Hollingsworth, M.D., a pulmonologist who is an assistant professor in the Department of Medicine at Duke University Medical Center and senior author of the paper. "We found hyaluronan to be directly responsible for causing the airways to narrow and become irritated. We believe this may contribute to asthma symptoms in humans as well."

The researchers found several proteins which can mediate the hyaluronan effect and can be used as treatment targets. They were also able to block the airway responsiveness by binding the native hyaluronan away, as well as by administering a slightly modified form of hyaluronan. "Although more research is needed before these findings can be translated to humans, we are optimistic these treatment options could prove beneficial to patients," said Hollingsworth.

"This finding has real-life therapeutic implications," said Garantziotis. The researchers point out there are approximately 4,500 hospital admissions and 900,000 school absences each year attributed to ozone exposure, especially on high-ozone alert days. "We identified several new approaches to the treatment of ozone-induced airway narrowing."

Ozone has been estimated, in an Environmental Protection Agency analysis, to cost the United States $5 billion a year as a result of premature deaths, hospitalizations and school absences. Inhalation of ozone can lead to irritation of the airways and increased wheezing, particularly in children and adults who have asthma and chronic obstructive lung disease. Ozone is formed in the inner atmosphere in the presence of sunlight from pollutants emitted from vehicles and other sources. Exposure occurs when people inhale air containing ozone.

"This collaborative effort exemplifies the powerful advances we can continue to make to improve human health by teaming the innovativeness of our in-house researchers with our grantees," said Linda S. Birnbaum, Ph.D., NIEHS director. "This is also a good example of how NIEHS is helping to bring a pool of creative, talented young scientists to the field of environmental health sciences."


'/>"/>

Contact: Robin Mackar
rmackar@niehs.nih.gov
919-541-0073
NIH/National Institute of Environmental Health Sciences
Source:Eurekalert

Related biology news :

1. Cell-building discovery could reduce need for some animal research
2. Evolution and climate change research advances at Rutgers-Camden
3. TGen and ASU researchers find drug that could reduce risk of Alzheimers
4. Research project to boost European fish farming
5. LSUSHC researchers find potential new target for hypertension treatment
6. UT Southwestern researchers disrupt biochemical system involved in cancer, degenerative disease
7. What we don’t know still hurts us, environmental researchers warn
8. Research uncovers surprising lion stronghold in war-torn central Africa
9. ASM biodefense and emerging diseases research meeting
10. Success for first outdoor, large-scale algae-to-biofuel research project in Nevada
11. UC Davis research shows that newly discovered drug reduces heart enlargement
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/15/2016)... ... Research and Markets has announced the addition of the "Global ... The report forecasts the global military biometrics market to grow at a ... has been prepared based on an in-depth market analysis with inputs from ... over the coming years. The report also includes a discussion of the ...
(Date:12/12/2016)... Dec. 12, 2016  Researchers at Trinity College, ... graphene by combining the material with Silly Putty. The ... pressure detector able to sense pulse, blood pressure, ... spider.  The research team,s findings ... read here:  http://science.sciencemag.org/content/354/6317/1257 ...
(Date:12/7/2016)... 7, 2016 BioCatch , the global leader ... patent portfolio, which grew to over 40 granted and pending patents. ... , , ... entitled " System, Device, and Method Estimating Force Applied to ... makers to forego costly hardware components needed to estimate the force and ...
Breaking Biology News(10 mins):
(Date:1/19/2017)... , ... January 18, 2017 , ... ... tech innovators, engineers, and scientists from around the world, was today awarded the ... awards program is based entirely on merit and decided upon by a dedicated ...
(Date:1/19/2017)... 18, 2017  Northwest Biotherapeutics, Inc. (OTCQB: NWBO) ("NW ... therapies for operable and inoperable solid tumor cancers, announced ... Officer of NW Bio, will present at the Phacilitate ... the Hyatt Regency Hotel in Miami, Florida ... session entitled "New Therapeutic Approaches – Expanding the Reach ...
(Date:1/18/2017)... 2017 According to a new market research report "In ... Disease), & End User (Molecular Diagnostic Laboratories, Academic and Research Institutions) - Global ... 739.9 Million by 2021 from USD 557.1 Million in 2016, growing at a ... ... MarketsandMarkets Logo ...
(Date:1/18/2017)... ... 18, 2017 , ... Executive search firm Slone Partners proudly ... to the advancement of the clinical trials segment. Hosted in Miami, this conference ... planning and management. , As executive talent specialists in the industries central ...
Breaking Biology Technology: