Navigation Links
Research finds new cause for common lung problem
Date:5/6/2013

New research has found that in cases of lung edema, or fluid in the lungs, not only do the lungs fail to keep water out as previously believed, but they are also allowing water to pump in.

"Usually, our lungs pump fluid out of the air space, and it was previously believed that this pump mechanism just stopped when people had lung edema," said Dr. Wolfgang Kuebler, a scientist at St. Michael's Hospital. "But we've found not only do they stop pumping fluid out as they're supposed to do, they've gotten confused and are actually pumping in the reverse direction, bringing fluid into the lungs."

The research was published online in Proceedings of the National Academy of Sciences of the United States of America.

Dr. Kuebler said this finding has important implications for the treatment of lung edema, a common symptom of heart disease. Stopping the pumping mechanism, although seemingly counterintuitive, is protective for the lung and important for effective treatment.

For the first time, this explains why Lasix, a commonly prescribed drug, works in treating lung edema it simply prevents the pumps from allowing fluid into the air spaces. Lasix was previously believed to work exclusively by targeting the kidneys.

"With this information, more effective drugs that target just the lungs, and not the kidneys, can now be developed," said Dr. Kuebler, also a scientist at the Li Ka Shing Knowledge Institute.

Dr. Kuebler points out that this mechanism of pumping fluid into the air spaces is similar to what happens in the fetal lung. In the womb, the lung works to pump fluids in and only after the baby is born, does that pumping mechanism reverse itself to pump fluid out. "You can actually now interpret lung edema as a regression of the adult lung to a fetal stage," he said.


'/>"/>

Contact: Kate Taylor
TaylorKa@smh.ca
647-393-7527
St. Michael's Hospital
Source:Eurekalert

Page: 1

Related biology news :

1. Researchers reveal new more precise method of performing electroconvulsive therapy
2. Researchers calculate the global highways of invasive marine species
3. New ACS journal Environmental Science and Technology Letters to rapidly publish urgent research
4. University of Maryland School of Medicine researchers find potential novel treatment for influenza
5. PTSD research: Distinct gene activity patterns from childhood abuse
6. New research shows weekend binge drinking could leave lasting liver damage
7. Synthetic biology research community grows significantly
8. Researchers pinpoint upper safe limit of vitamin D blood levels
9. European support for the first network of research and training in political ecology
10. Researchers track singing humpback whales on a Northwest Atlantic feeding ground
11. Huddersfield researchers publish a book exploring the link between evolution and criminal behavior
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/22/2016)... , March 22, 2016 ... report "Electronic Sensors Market for Consumer Industry by Type ... Others), Application (Communication & IT, Entertainment, Home ... Global Forecast to 2022", published by MarketsandMarkets, ... expected to reach USD 26.76 Billion by ...
(Date:3/17/2016)... 17, 2016 ABI Research, the leader ... global biometrics market will reach more than $30 ... from 2015. Consumer electronics, particularly smartphones, continue to ... anticipated to reach two billion shipments by 2021 ... Pavlakis , Research Analyst at ABI Research. "Surveillance ...
(Date:3/14/2016)... March 14, 2016 http://www.apimages.com ... --> - Renvoi : image disponible via ... --> --> DERMALOG, le ... de nouveaux lecteurs d,empreintes digitales pour l,enregistrement des ... sera utilisé pour produire des cartes d,identité aux ...
Breaking Biology News(10 mins):
(Date:5/18/2016)... ... ... Tech Coast Angels (TCA) today announced that the Angel Capital Association ... Summit last week in Philadelphia. , The award recognizes the single-most ingenious ... is the highest honor available for an early-stage company to receive from the Angel ...
(Date:5/18/2016)... Fort Washington, PA (PRWEB) , ... May 18, ... ... and at least 1,200 hospitalizations are a direct result of asthma complications.* Costing ... health challenge across the country. , “For too many, the ...
(Date:5/17/2016)... ... May 17, 2016 , ... ... waste reduction applications, announced today it will be showcasing ManureMagic™ at booth V1061 ... was featured in the Wall Street Journal last year and more recently made ...
(Date:5/17/2016)... , May 17, 2016 ... in Basel, Switzerland announced ... inhibitor of P38 mitogen-activated protein kinase. ... Strekin will build the necessary research foundation ... in which MAP Kinases play fundamental roles. Pamapimod ...
Breaking Biology Technology: