Navigation Links
Research finds new cause for common lung problem
Date:5/6/2013

New research has found that in cases of lung edema, or fluid in the lungs, not only do the lungs fail to keep water out as previously believed, but they are also allowing water to pump in.

"Usually, our lungs pump fluid out of the air space, and it was previously believed that this pump mechanism just stopped when people had lung edema," said Dr. Wolfgang Kuebler, a scientist at St. Michael's Hospital. "But we've found not only do they stop pumping fluid out as they're supposed to do, they've gotten confused and are actually pumping in the reverse direction, bringing fluid into the lungs."

The research was published online in Proceedings of the National Academy of Sciences of the United States of America.

Dr. Kuebler said this finding has important implications for the treatment of lung edema, a common symptom of heart disease. Stopping the pumping mechanism, although seemingly counterintuitive, is protective for the lung and important for effective treatment.

For the first time, this explains why Lasix, a commonly prescribed drug, works in treating lung edema it simply prevents the pumps from allowing fluid into the air spaces. Lasix was previously believed to work exclusively by targeting the kidneys.

"With this information, more effective drugs that target just the lungs, and not the kidneys, can now be developed," said Dr. Kuebler, also a scientist at the Li Ka Shing Knowledge Institute.

Dr. Kuebler points out that this mechanism of pumping fluid into the air spaces is similar to what happens in the fetal lung. In the womb, the lung works to pump fluids in and only after the baby is born, does that pumping mechanism reverse itself to pump fluid out. "You can actually now interpret lung edema as a regression of the adult lung to a fetal stage," he said.


'/>"/>

Contact: Kate Taylor
TaylorKa@smh.ca
647-393-7527
St. Michael's Hospital
Source:Eurekalert

Page: 1

Related biology news :

1. Researchers reveal new more precise method of performing electroconvulsive therapy
2. Researchers calculate the global highways of invasive marine species
3. New ACS journal Environmental Science and Technology Letters to rapidly publish urgent research
4. University of Maryland School of Medicine researchers find potential novel treatment for influenza
5. PTSD research: Distinct gene activity patterns from childhood abuse
6. New research shows weekend binge drinking could leave lasting liver damage
7. Synthetic biology research community grows significantly
8. Researchers pinpoint upper safe limit of vitamin D blood levels
9. European support for the first network of research and training in political ecology
10. Researchers track singing humpback whales on a Northwest Atlantic feeding ground
11. Huddersfield researchers publish a book exploring the link between evolution and criminal behavior
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/8/2017)... 7, 2017 The biometrics market has ... confluence of organizations, desires to better authenticate or ... (password and challenge questions), biometrics is quickly working ... The market is driven by use cases, though ... and enterprise uses cases, with consumer-facing use cases ...
(Date:2/7/2017)... New York , February 7, 2017 ... as ID Global Solutions Corporation [OTC: IDGS], ("Ipsidy" or ... management and electronic transaction processing services, is pleased to ... of the Company. Effective January 31, 2017, ... the Board of Directors, CEO and President.  An experienced ...
(Date:2/2/2017)... , Feb. 2, 2017   TapImmune, Inc. ... immuno-oncology company specializing in the development of innovative ... treatment of cancer and metastatic disease, announced today ... GMP manufacturing of a second clinical lot of ... folate receptor alpha. The manufactured vaccine product will ...
Breaking Biology News(10 mins):
(Date:3/1/2017)... ... March 01, 2017 , ... ... will demonstrate how concentrating on protection, productivity and quality can help food and ... range of solutions – from x-ray and checkweighing to vision inspection and metal ...
(Date:3/1/2017)... 2017  Elizabeth Young and Joshua Rosenthal , ... Washington University,s Health Workforce Speaker series. http://bit.ly/2lA6C8B ... will be speaking on March 9, 2017 at the ... Washington, DC at 12:00pm. The ... renowned speakers to examine new workforce configurations, their outcomes ...
(Date:2/28/2017)... Diego, California (PRWEB) , ... ... ... Inc., the supplier of 3D nano-porous silicon biosensors and instruments for sensitive, ... and St. Marianna University, School of Medicine in Japan. The collaborators expect ...
(Date:2/28/2017)... , Feb. 28, 2017  Phosphorus, a ... today the formation of the Phosphorus Scientific Advisory ... experts chosen to advise the company on the ... multi-site research initiatives. Please visit http://phosphorus.com/about-us/ ... initiatives. "We,ve gathered some of the ...
Breaking Biology Technology: