Navigation Links
Research finds new cause for common lung problem
Date:5/6/2013

New research has found that in cases of lung edema, or fluid in the lungs, not only do the lungs fail to keep water out as previously believed, but they are also allowing water to pump in.

"Usually, our lungs pump fluid out of the air space, and it was previously believed that this pump mechanism just stopped when people had lung edema," said Dr. Wolfgang Kuebler, a scientist at St. Michael's Hospital. "But we've found not only do they stop pumping fluid out as they're supposed to do, they've gotten confused and are actually pumping in the reverse direction, bringing fluid into the lungs."

The research was published online in Proceedings of the National Academy of Sciences of the United States of America.

Dr. Kuebler said this finding has important implications for the treatment of lung edema, a common symptom of heart disease. Stopping the pumping mechanism, although seemingly counterintuitive, is protective for the lung and important for effective treatment.

For the first time, this explains why Lasix, a commonly prescribed drug, works in treating lung edema it simply prevents the pumps from allowing fluid into the air spaces. Lasix was previously believed to work exclusively by targeting the kidneys.

"With this information, more effective drugs that target just the lungs, and not the kidneys, can now be developed," said Dr. Kuebler, also a scientist at the Li Ka Shing Knowledge Institute.

Dr. Kuebler points out that this mechanism of pumping fluid into the air spaces is similar to what happens in the fetal lung. In the womb, the lung works to pump fluids in and only after the baby is born, does that pumping mechanism reverse itself to pump fluid out. "You can actually now interpret lung edema as a regression of the adult lung to a fetal stage," he said.


'/>"/>

Contact: Kate Taylor
TaylorKa@smh.ca
647-393-7527
St. Michael's Hospital
Source:Eurekalert

Page: 1

Related biology news :

1. Researchers reveal new more precise method of performing electroconvulsive therapy
2. Researchers calculate the global highways of invasive marine species
3. New ACS journal Environmental Science and Technology Letters to rapidly publish urgent research
4. University of Maryland School of Medicine researchers find potential novel treatment for influenza
5. PTSD research: Distinct gene activity patterns from childhood abuse
6. New research shows weekend binge drinking could leave lasting liver damage
7. Synthetic biology research community grows significantly
8. Researchers pinpoint upper safe limit of vitamin D blood levels
9. European support for the first network of research and training in political ecology
10. Researchers track singing humpback whales on a Northwest Atlantic feeding ground
11. Huddersfield researchers publish a book exploring the link between evolution and criminal behavior
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/22/2017)... Calif. , March 21, 2017 ... analytics company serving law enforcement agencies, announced today the ... as director of public safety business development. ... diversified law enforcement experience, including a focus on the ... In his most recent position, Mr. Sheridan served as ...
(Date:3/16/2017)... Germany , March 16, 2017 CeBIT 2017 - Against identity ... Continue Reading ... Used combined in one project, multi-biometric solutions provide ... Used ... Systems) ...
(Date:3/9/2017)... MOUNTAIN VIEW, Calif. , March 9, 2017 ... and 23andMe , the leading personal genetics company, ... Zipongo can now provide customers with personalized nutrition plans ... and biometrics, but also genetic markers impacting how their ... Zipongo,s personalized food decision support platform uses biometrics such ...
Breaking Biology News(10 mins):
(Date:4/20/2017)... ... April 20, 2017 , ... ... a unique intellectual property (IP) sharing and commercialization model. , The Center for ... A main component of this effort is bringing the IP to the attention ...
(Date:4/19/2017)... ... 18, 2017 , ... The Vibrating Orifice Aerosol Generator (VOAG) ... monodisperse droplets of known diameters for research applications such as for calibrating droplet ... drying monodisperse droplets. , The VOAG requires forcing liquid out of an ...
(Date:4/19/2017)... ... , ... Nobilis Therapeutics Announces Completion of Landmark NBTX-001 Clinical Trial ... its Upcoming Post Traumatic Stress Disorder Trial , Nobilis Therapeutics, Inc. announced ... of its NBTX-001, a xenon-based therapeutic in the treatment of Panic Disorder. ...
(Date:4/19/2017)... PORTLAND, Oregon and PUNE, India , April 19, ... titled, "Membrane Microfiltration Market: Global Opportunity Analysis and Industry Forecast, 2014-2022 ," ... to garner $12,858 million by 2022, registering a CAGR of 9.6% from 2016 ... ... ...
Breaking Biology Technology: