Navigation Links
Research examines environmental triggers altering gene function in CFS patients
Date:2/23/2012

TORONTO, ON A University of Toronto Scarborough (UTSC) researcher is examining how environmental triggers might alter gene function in people with Chronic Fatigue Syndrome. The research could lead to better insights into the disease and eventually to new treatments.

Patrick O. McGowan, professor in the department of biological sciences and director of UTSC's Laboratory for Epigenetic Neuroscience, is looking at how environmentally triggered changes to gene expression might alter immune function and stress response in ways that contribute to the disease.

McGowan's field of study is epigenetics long-term changes in gene function that do not change the underlying DNA sequence. An epigenetic change wouldn't change a gene itself, but would influence whether, when and how the gene is turned off. Epigenetic changes can be caused by environmental triggers such as infections, toxins, stress, nutrition, and even the social environment.

McGowan will conduct the study into the epigenetics of CFS with a grant from the CFIDS Association of America. As part of the grant, he will have access to the SolveCFS Biobank, a collection of biological samples from CFS patients.

CFS, also known as Chronic Fatigue and Immune Dysfunction Syndrome (CFIDS), is a complex and debilitating chronic illness that affects the brain and multiple body systems. Symptoms include incapacitating fatigue and problems with concentration and short-term memory. Millions of North Americans are thought to suffer from the disease.

McGowan will look specifically at the relationship between a system called the hypothalamic-pituitary-adrenal (HPA) axis and immune function. The HPA axis is involved in the regulation of the stress response, and has effects on immune function and inflammation through cellular signaling mechanisms involving the steroid glucocorticoid.

McGowan's hypothesis is that there is an epigenetic mechanism in CFS that disrupts glucocorticoid si
'/>"/>

Contact: Don Campbell
dcampbell@utsc.utoronto.ca
416-208-2938
University of Toronto Scarborough
Source:Eurekalert

Page: 1 2

Related biology news :

1. Researchers discover how vitamin D inhibits inflammation
2. Study finds college students willing to donate genetic material to biobanks for research
3. Purdue researchers reveal role of protein mutation in Parkinsons disease
4. Engineering, geoscience faculty help lead $3 million NSF Delta research collaboration
5. UVic researchers among presenters at global science conference
6. AAAS-SFU research: Chilling climate-change related news
7. AAAS-SFU research: Linking human evolution and climate change
8. AAAS-SFU research: Controlling forest fires
9. Comments by the International Scientific Forum on Alcohol Research
10. Researchers develop better control for DNA-based computations
11. New research relationships developing due to dwindling dollars
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/2/2015)... 2, 2015 Fingerprint Cards has received ... and FPC1155 from the distributor World Peace Industrial Group (WPI), ... in Asia . Deliveries are planned to ... be used by smartphone manufacturers in Asia ... the communicated revenue guidance of approximately 2,200 MSEK for 2015. ...
(Date:6/26/2015)... ATL Technology, LLC, a top provider of electromechanical contract manufacturing ... headquartered in Springville, Utah , has announced ... corporation with locations in Santa Clara, CA ... ). This acquisition will incorporate MedConx,s manufacturing facility ... existing facility in Costa Rica , resulting ...
(Date:6/24/2015)... , June 24, 2015 The biologics safety ... major drivers for the market include growth of the ... new drug launches. Over the years, the number of ... 2001 and 2010, the FDA approved 225 drug applications ... WIPO, Europe accounted for 3,822 ...
Breaking Biology News(10 mins):FPC Receives Order for Touch Fingerprint Sensors of 268 MSEK 2ATL Technology Announces Acquisition of MedConx, Inc. and Expanded Global Footprint 2Biological Safety Testing Market by Application, Product, & Test - Global Forecast to 2019 2Biological Safety Testing Market by Application, Product, & Test - Global Forecast to 2019 3Biological Safety Testing Market by Application, Product, & Test - Global Forecast to 2019 4
... Netherlands,Thursday 25 April 2013: Probiotics could emerge as ... therapy after a new study announced at ... reduced development of the notoriously difficult-to-treat disease. ... preventing the development of HE in 160 cirrhotic ...
... Liver Congress 2013 include results from early in vitro ... (cccDNA), which may form the basis of a cure ... cccDNA is organized into mini-chromosomes within the nucleus of ... availability of efficient therapies against HBV, long-term persistence of ...
... 2013, a novel H7N9 influenza virus was identified in ... in humans, resulting in some deaths. A group of ... Reference Laboratory, State Key Laboratory of Veterinary Biotechnology, Harbin ... investigated the origins of this novel H7N9 influenza virus ...
Cached Biology News:Probiotics found to reduce hepatic encephalopathy 2Novel therapeutic approaches to cure chronic HBV infection 2Novel therapeutic approaches to cure chronic HBV infection 3Source identification of H7N9 influenza virus causing human infections 2Source identification of H7N9 influenza virus causing human infections 3
(Date:7/1/2015)... ... ... The next-generation sequencing (NGS) clinical market is poised for huge growth as ... Research reveals in its new report that the market drivers of this vibrant industry ... for better diagnostics as part of a molecular diagnostics trend. , The global market ...
(Date:7/1/2015)... HAMILTON, Bermuda , July 1, 2015 /PRNewswire/ ... biopharmaceutical company focused on the treatment of dementia, ... investor briefing on July 22 at 5:45 p.m. ... at the Alzheimer,s Association International Conference 2015 (AAIC). ... following remarks: , Dr. Lawrence ...
(Date:7/1/2015)... InferMed , s decision ... augment Elsevier ... suite   Elsevier , a world-leading provider ... today the acquisition of  InferMed , a London ... InferMed,s Arezzo technology supports clinicians in choosing the most appropriate ...
(Date:7/1/2015)... 1, 2015  UCB, a multinational biopharmaceutical company, ... leader in designing, transforming, and running intelligent business ... recognition of their close collaboration in driving transformation ... business services (GBS) finance organization. The ... that work together effectively to embrace the innovative ...
Breaking Biology Technology:NGS-Based Diagnostics, the ‘Must-Have Platform’, Sends Market Segment CAGRs Soaring According to BCC Research 2NGS-Based Diagnostics, the ‘Must-Have Platform’, Sends Market Segment CAGRs Soaring According to BCC Research 3Axovant Sciences To Host Investor Briefing And Live Webcast During AAIC 2015 Meeting 2Axovant Sciences To Host Investor Briefing And Live Webcast During AAIC 2015 Meeting 3Elsevier Acquires InferMed, Provider of Clinical Decision Support Technology 2Elsevier Acquires InferMed, Provider of Clinical Decision Support Technology 3Elsevier Acquires InferMed, Provider of Clinical Decision Support Technology 4UCB and Genpact Receive Aecus Innovation Award for Success in Global Business Services 2UCB and Genpact Receive Aecus Innovation Award for Success in Global Business Services 3UCB and Genpact Receive Aecus Innovation Award for Success in Global Business Services 4UCB and Genpact Receive Aecus Innovation Award for Success in Global Business Services 5
... Reportlinker.com announces that a new market research report ... Biomarkers - Technologies,markets and companies ... follows the broad definition of a biomarker as ... evaluated as an indicator of normal biological or ...
... 2011 Reportlinker.com announces that a new ... catalogue: The 2011 Blood ... Opportunities and Business Expansion Strategies for Suppliers ... During the next ten years, the ...
... YORK, March 7, 2011 NeoStem, Inc. (NYSE Amex: ... operations in the U.S. and China, is pleased to ... Vice President of Strategic Business Development. Jason was formerly ... the firm,s research effort in emerging biotechnology companies. Jason,s ...
Cached Biology Technology:Reportlinker Adds Biomarkers - Technologies, Markets and Companies 2Reportlinker Adds The 2011 Blood Banking Market: US, Europe, Japan - Emerging Opportunities and Business Expansion Strategies for Suppliers 2NeoStem Announces the Addition of Jason Kolbert as Vice President of Strategic Business Development 2NeoStem Announces the Addition of Jason Kolbert as Vice President of Strategic Business Development 3
pETDuet-1 is designed for the coexpression of two target genes....
Mouse Laminin-1 MAb (Clone AL-3)...
IEX-1 S/L (H-20)...
... Gia-1. Strong reactivity ... bovine (74%) and guinea pig ... human (31%). Specificity confirmed ... Gat, rat Goa, rat Gia-1, ...
Biology Products: