Navigation Links
Research examines environmental triggers altering gene function in CFS patients
Date:2/23/2012

TORONTO, ON A University of Toronto Scarborough (UTSC) researcher is examining how environmental triggers might alter gene function in people with Chronic Fatigue Syndrome. The research could lead to better insights into the disease and eventually to new treatments.

Patrick O. McGowan, professor in the department of biological sciences and director of UTSC's Laboratory for Epigenetic Neuroscience, is looking at how environmentally triggered changes to gene expression might alter immune function and stress response in ways that contribute to the disease.

McGowan's field of study is epigenetics long-term changes in gene function that do not change the underlying DNA sequence. An epigenetic change wouldn't change a gene itself, but would influence whether, when and how the gene is turned off. Epigenetic changes can be caused by environmental triggers such as infections, toxins, stress, nutrition, and even the social environment.

McGowan will conduct the study into the epigenetics of CFS with a grant from the CFIDS Association of America. As part of the grant, he will have access to the SolveCFS Biobank, a collection of biological samples from CFS patients.

CFS, also known as Chronic Fatigue and Immune Dysfunction Syndrome (CFIDS), is a complex and debilitating chronic illness that affects the brain and multiple body systems. Symptoms include incapacitating fatigue and problems with concentration and short-term memory. Millions of North Americans are thought to suffer from the disease.

McGowan will look specifically at the relationship between a system called the hypothalamic-pituitary-adrenal (HPA) axis and immune function. The HPA axis is involved in the regulation of the stress response, and has effects on immune function and inflammation through cellular signaling mechanisms involving the steroid glucocorticoid.

McGowan's hypothesis is that there is an epigenetic mechanism in CFS that disrupts glucocorticoid si
'/>"/>

Contact: Don Campbell
dcampbell@utsc.utoronto.ca
416-208-2938
University of Toronto Scarborough
Source:Eurekalert

Page: 1 2

Related biology news :

1. Researchers discover how vitamin D inhibits inflammation
2. Study finds college students willing to donate genetic material to biobanks for research
3. Purdue researchers reveal role of protein mutation in Parkinsons disease
4. Engineering, geoscience faculty help lead $3 million NSF Delta research collaboration
5. UVic researchers among presenters at global science conference
6. AAAS-SFU research: Chilling climate-change related news
7. AAAS-SFU research: Linking human evolution and climate change
8. AAAS-SFU research: Controlling forest fires
9. Comments by the International Scientific Forum on Alcohol Research
10. Researchers develop better control for DNA-based computations
11. New research relationships developing due to dwindling dollars
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/17/2014)... word for chili peppers. Information about archaeological remains of ... of the appearance of words for chili peppers in ... domesticated and highlight the value of multi-proxy data analysis. ... of nine papers presented in a special feature issue ... Sciences on plant and animal domestication edited by ...
(Date:4/17/2014)... NJ. April 16, 2014. Kessler Foundation has been ... million from the Department of Defense Spinal Cord ... principal investigator for the randomized, double-blinded, controlled, multi-site ... bone and muscle strength after spinal cord injury. ... & Engineering Research at Kessler Foundation. Two additional ...
(Date:4/17/2014)... Professor Marc Andr Gauthier and Professor Luca Razzari ... each been awarded large grants from the John ... for Innovation (CFI) for the acquisition of state-of-the-art ... be added matching grants from the Ministre de ... et de la Technologie (MESRST). These new laboratories ...
Breaking Biology News(10 mins):Chickens to chili peppers 2Chickens to chili peppers 3Kessler Foundation awarded Department of Defense grant for spinal cord injury research 2New state-of-the-art biotech and nanotech equipment for INRS 2
... revolutionize biomedical research, scientists have discovered a way to keep ... individual cancer patient alive in the laboratory which previously ... lab after dividing only a few times, and many common ... This new technique, described today online in the American ...
... activities has polluted lakes throughout the Northern Hemisphere for more ... evident even in remote lakes located thousands of miles from ... published in the journal Science Dec. 16, are ... deposits in 36 lakes using an approach similar to aquatic ...
... insects, high risk of attack has led to the ... in the larval stage. One caterpillar may look like ... Though crypsis may have its advantages, University of Florida ... caterpillars using another strategy previously best-known in adult butterflies: ...
Cached Biology News:Georgetown researchers lead discovery expected to significantly change biomedical research 2Nitrogen from humans pollutes remote lakes for more than a century 2Nitrogen from humans pollutes remote lakes for more than a century 3Caterpillars mimic one another for survival 2Caterpillars mimic one another for survival 3
(Date:1/14/2014)... Date: Friday, April 11, 2014 , Time: 6 ... Almshouse Road, Warrington, Pa. , Details: The Hepatitis ... finding a cure for hepatitis B and improving the quality ... Crystal Ball on Friday, April 11 at Warrington Country Club ...
(Date:1/14/2014)... pet owners drew up their lists of New Year,s resolutions for ... of my furry companion." Nowadays there are pet salons, dog and ... take the little canine or feline darlings along wherever mommy or ... pricey toys at the pet store. But anyone who has ever ...
(Date:1/14/2014)... iLab Solutions, the leader in core facility management software, ... Strategy. In this role, Michelle will work with current and ... the development of iLab products. Her main goal will be ... the scientific community by offering the most advanced, user-friendly, and ...
(Date:1/14/2014)... Kinaxis ®, provider of RapidResponse ®, a cloud-based supply ... ( S&OP ) service, is proud to be a gold ... held at the Hilton San Diego Bayfront, January 30 – ... Kaszas , Director of Supply Chain at Amgen, as she ...
Breaking Biology Technology:Hepatitis B Foundation to Host Annual Crystal Ball Gala 2New Year's Resolution: Give Pets the Gift of Top-Notch Health Care 2iLab Solutions Announces Michelle Detwiler as the New Director of Product Strategy 2Event Alert: Kinaxis Customer to Present at the Biomanufacturing Summit "Supply Chain: Improving Network Effectiveness" 2
... SOUTH SAN FRANCISCO, Calif., Nov. 21 ,Exelixis, Inc. (Nasdaq: ... the company,s president and chief executive officer will present ... 1:00 p.m.,ET / 10:00 a.m. PT on Wednesday, November ... may be accessed in the Event,Calendar page under Investors ...
... denounces life-destructive research in light of ... new discovery, ... have made a significant breakthrough in stem cell research,using adult skin cells ... Scientists from the University of Wisconsin at Madison announced that,they have identified ...
... to shine spotlight on crisis affecting 246 million ... people ... Day, leaders in the U.S. House of Representatives passed House,Concurrent Resolution 211 ... on November 14. Then, the next day, on,World Diabetes Day itself, the ...
Cached Biology Technology:Stem Cell Breakthrough Could End Human Embryonic Experimentation 2Novo Nordisk Applauds Adoption of World Diabetes Day Resolutions by U.S. Congress 2
... Custom Synthesis Service provides you ... to knockdown any gene. We ... base pairs with terminal dT ... other lengths of your choice. ...
Request Info...
...
Complete cell culture media with cytokines...
Biology Products: