Navigation Links
Research elucidates way lungs fight bacteria and prevent infection
Date:1/23/2009

NEW YORK (Jan. 23, 2009) Actor and pancreatic cancer patient Patrick Swayze's recent hospitalization with pneumonia as a result of his compromised immune system underscores the sensitivity of the lungs: many patients die from lung complications of a disease, rather than the disease itself.

Lungs are delicate and exposed to the environment, almost like an open wound. Consequently, the body has developed an elaborate immuno-defense system to combat inhaled pathogens and bacteria in a healthy individual, this system effectively blocks hundreds of potentially sickening assaults daily.

It works like this: airway epithelial cells initiate an immune response to inhaled bacteria by signaling for white blood cells to move from the bloodstream into the lungs and airway to fight potential infection.

For the first time, researchers at Columbia University Medical Center have demonstrated that this signaling cascade includes the activation of epithelial proteases, a type of enzyme capable of opening the junctions between the cells in the airway mucosa, to enable the white blood cells to get through to the site of the infection. The opening of these junctions is initiated by a change in calcium levels.

The work by Drs. Jarin Chun and Alice Prince in the Departments of Pharmacology and Pediatrics at Columbia's College of Physicians and Surgeons was published Jan. 22, 2009 in the journal Cell Host & Microbe.

Getting white blood cells to the site of an infection, however, is often a double-edged sword. On the one hand, having as many white blood cells as possible at the site of an infection is beneficial, but on the other hand too many white blood cells can lead to excessive inflammation, interfering with breathing and damaging the airways.

Cystic fibrosis is one disease where this work might have particular import, Dr. Chun says. People with cystic fibrosis possess an abnormal gene that causes normal mucus to become
'/>"/>

Contact: Alex Lyda
mal2133@columbia.edu
212-305-0820
Columbia University Medical Center
Source:Eurekalert

Page: 1 2

Related biology news :

1. 2009 Damon Runyon-Rachleff Innovation Awards granted for pioneering ideas in cancer research
2. Researchers genetically link Lou Gehrigs disease in humans to dog disease
3. Texas Medical Center researchers win collaborative grants
4. Research exposes the risk to infants from the chemicals used in liquid medicines
5. UD research study to shed light on emerging seaborne pathogen
6. Researchers describe protease inhibitor that may aid in diabetic retinopathy treatment
7. Researchers examine developing hearts in chickens to find solutions for human heart abnormalities
8. CIC to Host Webinar Featuring Independent Research Firm: Enabling Straight Through Processing - Why the Insurance Industry Needs Electronic Signature Technology
9. Leading research agencies announce new international competition: "The digging into data challenge"
10. JDRF-funded researchers discover proteins regulating human beta cell replication
11. New infant feeding and obesity research adds insight to ongoing issue
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/9/2014)... from the oils produced by algae may offer a ... goal, optimization of cost effective strategies for large-scale algae ... Sapphire Energy has developed an innovative solution to the ... described in Industrial Biotechnology , a peer-reviewed journal ... available on the Industrial Biotechnology website ...
(Date:7/9/2014)... URBANA, Ill. With over 100 diseases that can ... the top of the most wanted list? University of ... reason that more research is needed on the fungus ... associated with cool, damp growing conditions but Macrophomina ... hot and dry drought conditions. , "As the climate ...
(Date:7/9/2014)... from China challenges the commonly held belief that birds ... to fly. The birdlike fossil is actually not a ... of a tiny tree-climbing animal that could glide, say ... Blanding, Utah, and Alan Feduccia of the University of ... of Ornithology . , The fossil of the ...
Breaking Biology News(10 mins):Controlling contamination in open algae ponds for biofuels 2Climate change provides good growing conditions for charcoal rot in soybeans 2Climate change provides good growing conditions for charcoal rot in soybeans 3Researchers declassify dinosaurs as being the great-great-grandparents of birds 2
... Research Vessel Polarstern had to prove its ice breaking ... series of long-term research measurements. After working in regions ... Wegener Institute for Polar and Marine Research in the ... August 10th. "This year, we had to cope ...
... the University Of Southern California School Of Dentistry have uncovered ... process that leads to palate formation. Cleft palate ... in one out of every 700 live births. Clefts are ... descent. While males are twice as likely to have a ...
... Ikaria Holdings, Inc., a fully,integrated critical care ... Drug Administration (FDA) has granted orphan drug designation,for ... of the incidence and,severity of delayed graft function ... Rosskamp, M.D., Executive Vice President of Research and,Development ...
Cached Biology News:Successful series of measurements in Arctic sea ice 2Successful series of measurements in Arctic sea ice 3Successful series of measurements in Arctic sea ice 4USC researchers identify alternate pathway that leads to palate development 2USC researchers identify alternate pathway that leads to palate development 3Ikaria(R) Receives FDA Orphan Drug Designation for Inhaled Carbon Monoxide for Delayed Graft Function in Solid Organ Transplants 2
(Date:1/14/2014)... PA (PRWEB) January 14, 2014 Date: Friday, ... , Location: Warrington Country Club, 1360 Almshouse Road, Warrington, Pa. ... national nonprofit organization solely dedicated to finding a cure for ... affected worldwide, will host its annual Crystal Ball on Friday, ...
(Date:1/14/2014)... , Jan. 14, 2014 As pet owners drew up their ... of them wrote: "Take better care of my furry companion." Nowadays ... clothes and top-brand carrying cases to take the little canine or ... also feel compelled to buy some pricey toys at the pet ...
(Date:1/14/2014)... January 14, 2014 iLab Solutions, the leader ... the new Director of Product Strategy. In this role, Michelle ... iLab sub-teams to guide in the development of iLab products. ... the maximum possible benefit to the scientific community by offering ...
(Date:1/14/2014)... ®, provider of RapidResponse ®, a cloud-based supply chain ... S&OP ) service, is proud to be a gold sponsor ... at the Hilton San Diego Bayfront, January 30 – 31, ... , Director of Supply Chain at Amgen, as she presents ...
Breaking Biology Technology:Hepatitis B Foundation to Host Annual Crystal Ball Gala 2New Year's Resolution: Give Pets the Gift of Top-Notch Health Care 2iLab Solutions Announces Michelle Detwiler as the New Director of Product Strategy 2Event Alert: Kinaxis Customer to Present at the Biomanufacturing Summit "Supply Chain: Improving Network Effectiveness" 2
... Inc. (Nasdaq: SNMX ) will release its first ... the opening of the U.S. financial markets. The Company ... broadcast that will provide a corporate update and a review ... 11:00 a.m. Eastern Time (8:00 a.m. Pacific Time). To ...
... private insurers are placing unprecedented pressures on Life Sciences ... according to The 2009 Ernst & Young business risk ... to increase demands to demonstrate value in the years ... tax base, aging populations, and a mandate to provide ...
... April 23 HUNT Biosciences, the,commercial arm of ... the,appointment of former GE Healthcare director Per Foss ... healthcare companies with biomarker,discovery and validation services. These ... the past 25 years has gathered blood samples ...
Cached Biology Technology:SENOMYX, INC. FIRST QUARTER 2009 EARNINGS CONFERENCE CALL SCHEDULED FOR MAY 7, 2009 2Failing to Demonstrate Value of Innovation is Top Risk Facing Life Sciences Sector, According to Ernst & Young 2Failing to Demonstrate Value of Innovation is Top Risk Facing Life Sciences Sector, According to Ernst & Young 3Failing to Demonstrate Value of Innovation is Top Risk Facing Life Sciences Sector, According to Ernst & Young 4Former GE Healthcare Director, Per Foss Appointed CEO for HUNT Biosciences 2
... Simplify the process and you reduce ... built into the CEQ 8000. Developed using ... and leadership in capillary electrophoresis technology, the ... analysis system. This system automatically fills the ...
The external laser upgrade for the Molecular Imager FX adds a 635 nm external laser; the 555 nm long pass filter is replaced with a 605 nm band pass filter to distinguish Cy5 from 532 nm excitable dy...
... The APO-BRDU Kit is a 2-color ... total cellular DNA to detect apoptotic cells ... instructions and reagents required for measuring apoptosis ... cells for assessing reagent performance; washing, reaction ...
... The BioGenex VISION Sytem is a ... comes with proprietary digital imaging and ... digital image acquisition, analysis, archving/retrieval and ... a state-of-the-art digital imaging system that ...
Biology Products: