Navigation Links
Research elucidates way lungs fight bacteria and prevent infection
Date:1/23/2009

NEW YORK (Jan. 23, 2009) Actor and pancreatic cancer patient Patrick Swayze's recent hospitalization with pneumonia as a result of his compromised immune system underscores the sensitivity of the lungs: many patients die from lung complications of a disease, rather than the disease itself.

Lungs are delicate and exposed to the environment, almost like an open wound. Consequently, the body has developed an elaborate immuno-defense system to combat inhaled pathogens and bacteria in a healthy individual, this system effectively blocks hundreds of potentially sickening assaults daily.

It works like this: airway epithelial cells initiate an immune response to inhaled bacteria by signaling for white blood cells to move from the bloodstream into the lungs and airway to fight potential infection.

For the first time, researchers at Columbia University Medical Center have demonstrated that this signaling cascade includes the activation of epithelial proteases, a type of enzyme capable of opening the junctions between the cells in the airway mucosa, to enable the white blood cells to get through to the site of the infection. The opening of these junctions is initiated by a change in calcium levels.

The work by Drs. Jarin Chun and Alice Prince in the Departments of Pharmacology and Pediatrics at Columbia's College of Physicians and Surgeons was published Jan. 22, 2009 in the journal Cell Host & Microbe.

Getting white blood cells to the site of an infection, however, is often a double-edged sword. On the one hand, having as many white blood cells as possible at the site of an infection is beneficial, but on the other hand too many white blood cells can lead to excessive inflammation, interfering with breathing and damaging the airways.

Cystic fibrosis is one disease where this work might have particular import, Dr. Chun says. People with cystic fibrosis possess an abnormal gene that causes normal mucus to become
'/>"/>

Contact: Alex Lyda
mal2133@columbia.edu
212-305-0820
Columbia University Medical Center
Source:Eurekalert

Page: 1 2

Related biology news :

1. 2009 Damon Runyon-Rachleff Innovation Awards granted for pioneering ideas in cancer research
2. Researchers genetically link Lou Gehrigs disease in humans to dog disease
3. Texas Medical Center researchers win collaborative grants
4. Research exposes the risk to infants from the chemicals used in liquid medicines
5. UD research study to shed light on emerging seaborne pathogen
6. Researchers describe protease inhibitor that may aid in diabetic retinopathy treatment
7. Researchers examine developing hearts in chickens to find solutions for human heart abnormalities
8. CIC to Host Webinar Featuring Independent Research Firm: Enabling Straight Through Processing - Why the Insurance Industry Needs Electronic Signature Technology
9. Leading research agencies announce new international competition: "The digging into data challenge"
10. JDRF-funded researchers discover proteins regulating human beta cell replication
11. New infant feeding and obesity research adds insight to ongoing issue
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:6/23/2015)... Minn. , June 23, 2015   ... company that supports the entire spectrum of clinical ... iMedNet ™ , the company,s intuitive, ... been awarded a Silver 2015 Stevie® Award by ... Health Products & Services Website category.  The American ...
(Date:6/18/2015)... June 18, 2015 NXT-ID, Inc. (NASDAQ: NXTD ... on the growing mobile commerce market announces that its Wocket® ... on "Money on the Mark", scheduled to air on WABC ... June 20 th . The broadcast air- ... 7:00 to 8:00pm EST. NXT-ID, Inc.,s CEO Gino Pereira ...
(Date:6/16/2015)... , June 16, 2015 /CNW Telbec/ - handyem ... centralized around the incorporation of handyem,s HPC-150 portable ... laboratory, the Mo-POD™. This unprecedented model of mobile ... Conference at the Pennsylvania ... June 15 th to 18 th ...
Breaking Biology News(10 mins):MedNet Solutions' iMedNet eClinical Wins Silver Stevie Award 2NXT-ID, Inc.'s CEO Gino Pereira Talks About the Wocket Smart Wallet on WABC Radio, New York City, June 20th 2NXT-ID, Inc.'s CEO Gino Pereira Talks About the Wocket Smart Wallet on WABC Radio, New York City, June 20th 3handyem and FlowMetric Diagnostics announce their partnership in the development of Flow Cytometry- Based Solutions in diagnostic capabilities 2handyem and FlowMetric Diagnostics announce their partnership in the development of Flow Cytometry- Based Solutions in diagnostic capabilities 3
... -- A two-year study of college students at ... learn better and develop higher-level skills by participating ... teaching methods. Elsa Snchez and Richard Craig, ... surveyed students enrolled from 2003-2005 in their Plant ...
... -- We love it fresh, canned and frozen. It,s grown ... by the American Society of Horticultural Science, adds up to ... In other words, sweet corn is big business. Fresh ... July, with only ten percent of the annual volume marketed ...
... Two common dietary molecules found in legumes and ... of radiation, researchers from the University of Maryland ... human skin cells and a skin cancer-prone mouse ... damaging radiation found in sunlight, the team reported ...
Cached Biology News:Teamwork improves learning and career success 2How sweet is it? 2Antioxidants could provide all-purpose radiation protection 2Antioxidants could provide all-purpose radiation protection 3
(Date:6/29/2015)... and Manhattan, KS (PRWEB) , ... June 29, ... ... acquired US PATENT 7736892 B2. Under the terms of the agreement, MediVet will ... Cord Matrix Stem Cells (UCMSCs). MB-007 is currently in pre-clinical development as a ...
(Date:6/29/2015)... Md. , June 29, 2015  Neuralstem, Inc. ... cell technology to develop small molecule and cell therapy ... it has been approved for listing on the NASDAQ ... stock will continue to trade on the NYSE MKT ... on the NASDAQ Capital Market is expected to commence ...
(Date:6/29/2015)... 2015 Elsevier , a ... and services, today announced the highlights of its journal ... Journal Citation Reports® (JCR) published by Thomson Reuters, Elsevier ... 2013 to 2014, ahead of the aggregate across other ... in 62 subject categories, up from 61 in 2013. ...
(Date:6/26/2015)... STRASBURG, Va. , June 26, 2015  A ... release two products made with synthetic rhino horn: beer ... in Vietnam . In response to ... oppose the manufacture, marketing and sale of synthetic rhino ... (IRF) and Save the Rhino International ...
Breaking Biology Technology:MediVet Biologics Acquires Exclusive Patent License from Kansas State University 2MediVet Biologics Acquires Exclusive Patent License from Kansas State University 3Neuralstem, Inc. Announces Approval for Listing on the NASDAQ Capital Market 2Neuralstem, Inc. Announces Approval for Listing on the NASDAQ Capital Market 3Elsevier Announces 2014 Citation Impact Highlights 2Elsevier Announces 2014 Citation Impact Highlights 3Rhino Experts Oppose Synthetic Rhino Horn as Solution to Poaching Crisis 2
... chemists from the University of Valencia (UV) has confirmed that ... remains at Lixus, in Morocco, was pine resin. The scientists ... could be fragments of material used for iron-working. In ... sealed amphora among the remains at Lixus, an ancient settlement ...
... , Feb. 5 Transgenomic, Inc. (OTC Bulletin Board: TBIO) ... will be presenting a corporate overview of the company at the 12th ... 11:30 a.m. EST on Tuesday, February 9, 2010 ... , About Transgenomic, Inc. , Transgenomic, Inc. ...
... and PALO ALTO, Calif. , Feb. 5 ... Philip Haworth , Ph.D., chief executive officer, will deliver a corporate ... Conference.  The conference will be held February 8-9, 2010 at ... will take place at 11:00 a.m. Eastern on Monday, ...
Cached Biology Technology:Chemical analyses uncover secrets of an ancient amphora 2Transgenomic Presents at 12th Annual BIO CEO & Investor Conference 2Silence Therapeutics to Present at 12th Annual BIO CEO & Investor Conference 2Silence Therapeutics to Present at 12th Annual BIO CEO & Investor Conference 3
Curcumin is an extract of turmeric root with antioxidant, anti-tumor promoter, and anti-inflammatory properties. Curcumin inhibits the induction of NOS in macrophages....
UGT1A6 (D-20)...
... is the smallest electronic pressure controller available ... Parker configured this unit specifically for the ... Used in carrier gas flow control, microfluidic ... and hydro-dynamic focusing, the OEM-EPC offers external ...
... Thrust Slide is designed for heavy duty ... limited and substantial side-loading is present. Standard ... millions of trouble-free cycles even in high ... or recirculating ball bearings , Optional corrosion ...
Biology Products: