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Research discovers frequent mutations of chromatin remodeling genes in TCC of the bladder
Date:8/7/2011

unknown to be mutated in TCC." said Professor Yaoting Gui,the co-leading author of the study and Vice-Director of the Institute of Urology at Peking University Shenzhen Hospital, "Another interesting finding is that eight genes among them are associated with chromatin remodeling, which could be related with frequent mutations in the majority of TCCs."

"We identified the genetic aberrations of the chromatin remodeling genes in 59% of the 97 individuals with TCC, and discovered one gene, UTX, could be altered substantially more frequently in tumors with low stages and grades." said Guangwu Guo, one of the co-leading authors of the study and PI of this project at BGI. "This study indicates UTX may pose a potential role in the classification and diagnosis of bladder cancer."

As we all know, aberrations of the chromatin remodeling genes may directly lead to the misregulation of multiple downstream effector genes, consequently promoting the tumor genesis process. "In our study, the newly discovered genetic mutations in the chromatin remodeling genes, except for UTX, are previous unknown in the primary tumors of TCC." said professor Cai. "Our results demonstrate that the disruption of the chromatin remodeling machinery may be one of the main mechanisms that lead to TCC."

Professor Jun Wang, Executive Director of BGI, said, "This study provides further understanding of bladder cancer and other human cancers through the comprehensive analysis of genetic alterations in TCC. It also implicates the necessity to enhance the epigenomics research in the field of cancer studies in the future. "


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Contact: Lei Su
BGI-Marketing@genomics.cn
86-075-525-283-805
Beijing Genomics Institute
Source:Eurekalert

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