Navigation Links
Research by Saint Louis University scientists offers way to disrupt fibrosis
Date:11/10/2013

ST. LOUIS A team of scientists that includes Saint Louis University researchers has identified a new way to intervene in the molecular and cellular cascade that causes fibrosis a condition where the body's natural process of forming scars for wound healing goes into overdrive and causes diseases. The findings, published Nov. 10 in the advance online issue of Nature Medicine, demonstrate a potential novel therapeutic approach to treat fibrotic diseases such as idiopathic pulmonary fibrosis and liver fibrosis.

The research targets a pathway that turns off the trigger for the major molecular mediator of fibrosis, a protein called Transforming Growth Factor (TGF) beta. This protein is normally present in the body in an inactive state and must be turned on to cause fibrosis. Once activated, TGF beta protein stimulates cells called myofibroblasts to produce excess collagen, which is a principle component of scars.

The researchers showed that removing a gene in the myofibroblasts that makes a specific subset of proteins called alpha v integrins blocks the ability of these cells to trigger activation of TGF beta. Furthermore, they were able to replicate the effect of the gene deletion by treatment with a small molecule compound, thus opening the door to a potential new therapy for patients.

"This is the first foray into targeting not just a single integrin, but rather several integrins that appear to be working in concert to promote fibrosis," said David Griggs, Ph.D., Director of Biology at Saint Louis University's Center for World Health and Medicine and an author of the paper.

"We have developed small molecular compounds that selectively inhibit these integrins, which suppress TGF beta protein, and these have been effective in animal models of lung and liver fibrosis."

The small molecule was not only able to prevent fibrosis; it made fibrosis less severe even when the treatment was started after fibrosis had
'/>"/>

Contact: Nancy Solomon
solomonn@slu.edu
314-977-8017
Saint Louis University
Source:Eurekalert

Page: 1 2

Related biology news :

1. Research reveals roles for exercise and diet in aging, depression
2. NSF awards to UT Arlington researchers will fuel sustainable solutions
3. OHSU Vollum Institute research gives new insight into how antidepressants work in the brain
4. Researchers uncover origins of cattle farming in China
5. UT Southwestern researchers identify how body clock affects inflammation
6. Researchers suggest plan to address hypoxia in Gulf of Mexico
7. Researchers advocate for climate adaptation science
8. UMMS researchers answer century old question about 3D structure of mitotic chromosomes
9. NIH funds researchers using light to control and monitor neural activity
10. Researchers regrow hair, cartilage, bone, soft tissues
11. Research shows that the more chocolate you eat, the lower your body fat level is
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:11/21/2014)... DALLAS , November 18, 2014 ... Security Systems Market by Systems (Video, RFID, Access Control, ... (SEZ, Factories, Hotels, Banks, Government), Component Service Geography - ... Security Systems Market is projected to be around $25 ... Billion by 2020, growing at a CAGR of 8.69%. ...
(Date:11/21/2014)... , Nov. 20, 2014 C-Labs LLC, ... the Internet of Things (IoT), today announced the appointment ... chief operating officer. Previously a strategic advisor to the ... and operations. Mr. Traynor is based out of the ... He reports to Chris Muench , Chief Executive ...
(Date:11/18/2014)... 17, 2014   News Highlights: ... to develop The Partners Data Lake, an agile ... Data Lake will allow researcher and clinicians to ... and the lives of patients , The ... activities across the Partners system, breaking down physical ...
Breaking Biology News(10 mins):Industrial Security Systems Market Worth $38 Billion by 2020 2Industrial Security Systems Market Worth $38 Billion by 2020 3C-Labs Names Former Microsoft and Bsquare Executive as Chief Operating Officer 2Partners HealthCare and EMC Unite to Solve Health Care's Toughest Challenges Using Big Data 2Partners HealthCare and EMC Unite to Solve Health Care's Toughest Challenges Using Big Data 3Partners HealthCare and EMC Unite to Solve Health Care's Toughest Challenges Using Big Data 4Partners HealthCare and EMC Unite to Solve Health Care's Toughest Challenges Using Big Data 5
... the University of Leicester are investigating how the stuff of ... the human reproductive system. Hydrogen sulphide partially responsible for ... gas and has been used for chemical warfare. But ... beneficial effects it has in the body- and the potentially ...
... way to turn off a key signaling pathway involved in ... and other diseases. The findings may lead to new treatments ... In the study, which is currently available in the online ... that by activating a receptor in cells called the liver ...
... billionths of a millimeter in size. Exhibiting novel and often ... stream of equally innovative products. In medical therapies, for example, ... into cells. So far, the only way of testing these ... show the activation of a transported gene inside a ...
Cached Biology News:UCLA researchers discover new molecular pathway for targeting cancer, disease 2Chasing tiny vehicles 2Chasing tiny vehicles 3
(Date:12/24/2014)... , December 23, 2014 ... Algeria , out today and available for free download ... actors driving change and growth in the sector today. ... scored notable successes has been in developing a homegrown pharmaceutical ... percent local production still remains some way off. A cursory ...
(Date:12/24/2014)... Dec. 23, 2014  Rock Creek Pharmaceuticals, Inc., (NASDAQ: ... filed a Clinical Trial Application (CTA) with the ... Agency (MHRA) seeking regulatory approval to initiate clinical trials ... Citrate. Contingent on the Company receiving CTA ... I trial to assess the safety, tolerability and dose ...
(Date:12/22/2014)... Brussels (PRWEB) December 22, 2014 The ... the global leader of technical training across the life ... Clinical Data Management (SCDM) to provide the organization's ... certification programs —providing access to the more than 350 ... SCDM members with 10% off when registering for a ...
(Date:12/22/2014)... - RepliCel Life Sciences Inc. (OTCQB: REPCF) (TSX.V: RP), ... development of autologous cell therapies, announced today the publication ... in conjunction with co-authors from Kyoto University and the ... ongoing clinical research using dermal sheath cup (DSC) cells ... The paper entitled " Hair Follicle Dermal Stem Cells ...
Breaking Biology Technology:PharmaBoardroom Releases New Algeria Pharmaceuticals Report 2PharmaBoardroom Releases New Algeria Pharmaceuticals Report 3Rock Creek Pharmaceuticals Files Clinical Trial Application in the UK for Clinical Trials of Anatabine Citrate Formulations 2Rock Creek Pharmaceuticals Files Clinical Trial Application in the UK for Clinical Trials of Anatabine Citrate Formulations 3CfPIE Announces Partnership with the Society for Clinical Data Management 2CfPIE Announces Partnership with the Society for Clinical Data Management 3Newly Released Peer-Reviewed Publication Further Validates RepliCel's Use of Dermal Sheath Cup Cells to Treat Pattern Baldness 2Newly Released Peer-Reviewed Publication Further Validates RepliCel's Use of Dermal Sheath Cup Cells to Treat Pattern Baldness 3Newly Released Peer-Reviewed Publication Further Validates RepliCel's Use of Dermal Sheath Cup Cells to Treat Pattern Baldness 4Newly Released Peer-Reviewed Publication Further Validates RepliCel's Use of Dermal Sheath Cup Cells to Treat Pattern Baldness 5
...  Verenium Corporation (Nasdaq: VRNM ), a leading ... of high-performance enzymes, today announced that James Levine, Executive ... the upcoming Baird 2011 Clean Technology Conference.  The presentation ... Thursday, December 1, 2011 and will take place at ...
... Inc. (OTCBB: MDRM) (the "Company") is pleased to announce ... its closing agreement to acquire all of the common ... Mobility Aids, Inc. is a Nevada-based Company whose strategic ... Bio-Pharma sector as well as scalable manufacturing in niche ...
... Santa Barbara, Calif. Professor Kaustav Banerjee, a ... the Nanoelectronics Research Lab at the University of California, ... international research award by the Electrostatic Discharge Association (ESDA). ... competitive and meant to recognize cutting edge research ideas ...
Cached Biology Technology:Verenium to Present at Baird Clean Technology Conference 2Verenium to Present at Baird Clean Technology Conference 3Modern Mobility Aids, Inc. Secures Financing to Close Acquisition Agreement of LumiGene Technologies 2Modern Mobility Aids, Inc. Secures Financing to Close Acquisition Agreement of LumiGene Technologies 3UCSB professor receives award for graphene electronics research 2
... Contents include: Microarray hybridization chamber ... chamber top, clamp, thumbscrew) Microarray chamber user ... and are intended to be cleaned and ... with Agilents Catalog Oligo Microarray kits and ...
Formula variant: With the macro- and micronutrients as described by Lloyd and McCown (1981). Preparation Quantity Equivalency: Formulated to contain 2.3 grams of powder per liter of medium. Physical ...
... Staining Kit is a very sensitive immunohistochemical ... cells, containing both anti-von Willebrand Factor and ... a variety of species. This AP kit ... staining of frozen and paraffin-embedded sections in ...
... For separation ... proteins Efficient separation of nuclei ... reduction in sample complexity, greatly ... proteins Subfractionation of nucleic acid ...
Biology Products: