Navigation Links
Research by Saint Louis University scientists offers way to disrupt fibrosis
Date:11/10/2013

ST. LOUIS A team of scientists that includes Saint Louis University researchers has identified a new way to intervene in the molecular and cellular cascade that causes fibrosis a condition where the body's natural process of forming scars for wound healing goes into overdrive and causes diseases. The findings, published Nov. 10 in the advance online issue of Nature Medicine, demonstrate a potential novel therapeutic approach to treat fibrotic diseases such as idiopathic pulmonary fibrosis and liver fibrosis.

The research targets a pathway that turns off the trigger for the major molecular mediator of fibrosis, a protein called Transforming Growth Factor (TGF) beta. This protein is normally present in the body in an inactive state and must be turned on to cause fibrosis. Once activated, TGF beta protein stimulates cells called myofibroblasts to produce excess collagen, which is a principle component of scars.

The researchers showed that removing a gene in the myofibroblasts that makes a specific subset of proteins called alpha v integrins blocks the ability of these cells to trigger activation of TGF beta. Furthermore, they were able to replicate the effect of the gene deletion by treatment with a small molecule compound, thus opening the door to a potential new therapy for patients.

"This is the first foray into targeting not just a single integrin, but rather several integrins that appear to be working in concert to promote fibrosis," said David Griggs, Ph.D., Director of Biology at Saint Louis University's Center for World Health and Medicine and an author of the paper.

"We have developed small molecular compounds that selectively inhibit these integrins, which suppress TGF beta protein, and these have been effective in animal models of lung and liver fibrosis."

The small molecule was not only able to prevent fibrosis; it made fibrosis less severe even when the treatment was started after fibrosis had
'/>"/>

Contact: Nancy Solomon
solomonn@slu.edu
314-977-8017
Saint Louis University
Source:Eurekalert

Page: 1 2

Related biology news :

1. Research reveals roles for exercise and diet in aging, depression
2. NSF awards to UT Arlington researchers will fuel sustainable solutions
3. OHSU Vollum Institute research gives new insight into how antidepressants work in the brain
4. Researchers uncover origins of cattle farming in China
5. UT Southwestern researchers identify how body clock affects inflammation
6. Researchers suggest plan to address hypoxia in Gulf of Mexico
7. Researchers advocate for climate adaptation science
8. UMMS researchers answer century old question about 3D structure of mitotic chromosomes
9. NIH funds researchers using light to control and monitor neural activity
10. Researchers regrow hair, cartilage, bone, soft tissues
11. Research shows that the more chocolate you eat, the lower your body fat level is
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:7/14/2014)... How does oxygen control insect body size? What influence does ... first issue of Current Opinion in Insect Science ... questions. , Current Opinion in Insect Science is ... is a review journal that aims to provide specialists with ... of information published in the field of insect science. First ...
(Date:7/14/2014)... Biogerontology Research Foundation (BGRF), a UK-based charity founded ... of a rapidly ageing population, hosted the inaugural ... with Aging Analytics, a company supporting financial decision-making ... The speakers at the forum included: , Dmitry ... on ,Impact Investment to Advance Longevity Research, , ...
(Date:7/14/2014)... Kansas scientists to the discovery and description of Rhipidocyrtus ... specimen, which turned out to represent a new genus and ... wedge beetle from Borneo is discussed in a recent paper ... . , The holotype male, and only known specimen of ... Borneo but subsequent to this it was transferred among several ...
Breaking Biology News(10 mins):BGRF hosts inaugural 21st Century Medicine Forum 2Serendipity at the Smithsonian: The 107-year journey of the beetle Rhipidocyrtus muiri 2Serendipity at the Smithsonian: The 107-year journey of the beetle Rhipidocyrtus muiri 3
... N.C. Feb. 28, 2013 Researchers at Wake ... special population of adult stem cells in bone marrow ... intestine and produce intestinal cells, suggesting their potential to ... (IBD). Up to 1 million Americans have IBD, ...
... -- In a new study, biologists will investigate the ... has killed a record number of frogs, toads and ... received a $595,000 grant from the National Science Foundation ... and a fungus called Batrachochytrium dendrobatidis (Bd). ...
... decimate the normal intestinal microbiota, which may never ... the GI tract vulnerable to being colonized by ... New York, NY, and Centro Superior de Investigacin ... normal microbial diversity largely eliminated vancomycin-resistant enterococci (VRE) ...
Cached Biology News:Research supports promise of cell therapy for bowel disease 2Biologists explore link between amphibian behavior and deadly disease 2Biologists explore link between amphibian behavior and deadly disease 3Good bacteria may expunge vancomycin-resistant bacteria from your gut 2
(Date:7/14/2014)... RESEARCH TRIANGLE PARK, N.C. , July 14, ... company focused on cloud-based drug design and development, ... and development program. The company has been granted ... inhibitors of multiple parasitic targets.  ... at the Argonne Leadership Computing Facility (ALCF), researchers ...
(Date:7/14/2014)... Throughout this past June 100s of ... space, representing 38 countries globally, registered for Xtalks ... Participation in Clinical Trials. Attract. Engage. Retain.” , ... R&D expert, Ken Getz, of Tufts CSDD, who ... through Patient Centricity. , Throughout this complimentary six-part ...
(Date:7/14/2014)... 2014 Minerva Neurosciences (NASDAQ: NERV ... to treat neuropsychiatric diseases and disorders, today announced that ... president of finance and chief accounting officer, effective June ... executive with more than 20 years of experience in ... companies. His background includes the management of compliance and ...
(Date:7/14/2014)... (PRWEB) July 14, 2014 ... registry platform, announced that three PatientCrossroads-based patient ... the Phelan-McDermid Syndrome International Registry; and the ... been awarded contracts by the Patient-Centered Outcomes ... creation of a new health data network ...
Breaking Biology Technology:Cloud Pharmaceuticals Granted 1M Hours of Supercomputer Time to Target Orphan Diseases Including Malaria 2Optimizing Patient Participation in Clinical Trials: Attract. Engage. Retain. – eCongress eBox Archives Now Available 2Optimizing Patient Participation in Clinical Trials: Attract. Engage. Retain. – eCongress eBox Archives Now Available 3Optimizing Patient Participation in Clinical Trials: Attract. Engage. Retain. – eCongress eBox Archives Now Available 4Optimizing Patient Participation in Clinical Trials: Attract. Engage. Retain. – eCongress eBox Archives Now Available 5Minerva Neurosciences Announces Appointment Of Frederick W. Ahlholm As VP Of Finance And Chief Accounting Officer 2PatientCrossroads Fuels Development of New National Clinical Research Network 2PatientCrossroads Fuels Development of New National Clinical Research Network 3
... Suzanne DeCann visits the University of Wisconsin-Eau Claire ... to pick up her newly earned Master of Business Administration ... the first 11 UW-Eau Claire students to earn their MBAs ... shell get her first real look at the campus and ...
... South Carolina , a health insurance provider that ... its evolving document communication needs by designating two ... Esker DeliveryWare Platform and Esker Fax respectively provide ... fax. , ,BlueCross BlueShield has enlisted Esker software ...
... Middleton-based provider of testing instruments used in support of ... announced the purchase of Masthead Imagings assets. ... are the PIPSpro software package and QC-3 phantom, for ... PIPSpro software displays, enhances and analyzes portal images and ...
Cached Biology Technology:UW-Eau Claire graduates first online MBAs 2UW-Eau Claire graduates first online MBAs 3Blue Cross BlueShield of South Carolina implements Esker solutions 2Standard Imaging acquires Canadian PIPSpro radiation treatment technologies 2
... of Taq DNA polymerase. It is a ... Expressed from a gene construct in E. ... 5'-3' exonuclease domain of the DNA polymerase-encoding ... and even more heat-stable DNA polymerase activity ...
... (ELISA) test kits are qualitative one-step kits ... of drugs and/or their metabolites in forensic ... use only. It is recommended that all ... method such as GC/MS. The simple ...
... inhibitor that noncovalently binds and inactivates neutral pancreatic ... RNase 1, T1, T2, H, U1, U2 or ... inhibitor in that it has a more robust ... RNase in the absence of DTT or other ...
...
Biology Products: