Navigation Links
Research breakthrough selectively represses the immune system
Date:11/18/2012

Reporters, please see "For news media only" box at the end of the release for embargoed sound bites of researchers.

In a mouse model of multiple sclerosis (MS), researchers funded by the National Institutes of Health have developed innovative technology to selectively inhibit the part of the immune system responsible for attacking myelinthe insulating material that encases nerve fibers and facilitates electrical communication between brain cells.

Autoimmune disorders occur when T-cellsa type of white blood cell within the immune systemmistake the body's own tissues for a foreign substance and attack them. Current treatment for autoimmune disorders involves the use of immunosuppressant drugs which tamp down the overall activity of the immune system. However, these medications leave patients susceptible to infections and increase their risk of cancer as the immune system's normal ability to identify and destroy aberrant cells within the body is compromised.

Supported by the National Institute of Biomedical Imaging and Bioengineering (NIBIB) at NIH, Drs. Stephen Miller and Lonnie Shea at Northwestern University, Evanston, teamed up with researchers at the University of Sydney, and the Myelin Repair Foundation in Saratoga, Calif. to come up with a novel way of repressing only the part of the immune system that causes autoimmune disorders while leaving the rest of the system intact.

The new research takes advantage of a natural safeguard employed by the body to prevent autoreactive T-cellswhich recognize and have the potential to attack the body's healthy tissuesfrom becoming active. They report their results in the Nov. 18 online edition of Nature Biotechnology.

"We're trying to do something that interfaces with the natural processes in the body," said Shea. "The body has natural mechanisms for shutting down an immune response that is inappropriate, and we're really just looking to tap into that."

O
'/>"/>

Contact: Margot Kern
nibibpress@mail.nih.gov
301-496-3500
NIH/National Institute of Biomedical Imaging & Bioengineering
Source:Eurekalert

Page: 1 2 3 4

Related biology news :

1. Notre Dame research could improve sustainability and cost effectiveness of wastewater treatment
2. USDA funded research leads to key discoveries in the pig genome
3. Dartmouth research: The clocks are ticking and the climate is changing
4. A class of RNA molecules protects germ cells from damage, Penn vet researchers show
5. Researchers sequence swine genome, discover associations that may advance animal and human health
6. Researchers uncover some good news for BCs troubled salmon populations
7. Researchers use GPS tracking to monitor crab behavior
8. University of Michigan, Michigan State University award grants for Great Lakes climate change research
9. GW Research chosen as paper of the week for blood coagulation discovery
10. Researchers tap into CO2 storage potential of mine waste
11. NIH awards Penn scientists $10 million over 5 years for innovative research on single cells
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:12/10/2014)... , Dec. 08, 2014 Research and Markets ... addition of the "Biometrics Market in Japan ... http://photos.prnewswire.com/prnh/20130307/600769 The ... such as rural banking and upgradation of the ... witnessed in the market. Besides the aforementioned projects, ...
(Date:12/3/2014)... 2, 2014   Marvin Test Solutions , ... solutions for military, aerospace, and manufacturing organizations, today ... successful TS-900 PXI semiconductor test platform . ... high-end systems to customers at a fraction of ... traditional ATE. "Our semiconductor customers ...
(Date:11/21/2014)... 2014 C-Labs LLC, a leading provider of ... (IoT), today announced the appointment of John Traynor ... a strategic advisor to the firm, Mr. Traynor will ... is based out of the C-Labs office in ... Chris Muench , Chief Executive Officer. Photo ...
Breaking Biology News(10 mins):Biometrics Market in Japan 2014-2018: Key Vendors are DDS, Fujitsu, Hitachi and NEC 2Marvin Test Solutions Brings New Capabilities to PXI-Based Semiconductor Test with TS-960 2Marvin Test Solutions Brings New Capabilities to PXI-Based Semiconductor Test with TS-960 3C-Labs Names Former Microsoft and Bsquare Executive as Chief Operating Officer 2
... & Science University researchers have identified some of the ... caused by multiple sclerosis (MS), complications of premature birth, ... clues about why the nervous system fails to repair ... of brain damage could be reversed. The research is ...
... information can be processed unconsciously when the area of ... temporarily shut down, according to research at Rice University ... Oct. 31 in the Proceedings of the National Academy ... has more than one pathway along which visual information ...
... identified some of the key factors that prevent the ... complications of premature birth, and other diseases and conditions. ... system fails to repair itself and suggest ways that ... reversed. The research is published in the August edition ...
Cached Biology News:Molecular Partners Required For Appropriate Neuronal Gene Repression 2Molecular Partners Required For Appropriate Neuronal Gene Repression 3Molecular Partners Required For Appropriate Neuronal Gene Repression 4Out of sight, out of mind? Not necessarily 2OHSU researchers discover potential mechanism to repair brain damage linked to Multiple Sclerosis 2OHSU researchers discover potential mechanism to repair brain damage linked to Multiple Sclerosis 3OHSU researchers discover potential mechanism to repair brain damage linked to Multiple Sclerosis 4
(Date:12/24/2014)... Texas (PRWEB) December 23, 2014 ... methyl mercaptan such as its definition, classification, ... presents product specification, manufacturing process, and product ... technology and applications. The analysis also covers ... marketing channels, industry development trend and proposals. ...
(Date:12/24/2014)... Pipette.com announces their Holiday in the ... their #HolidayInTheLab pictures for a chance to win pipette-themed ... those struggling to think of a holiday gift for ... Lab Contest provides the ideal holiday presents. The #HolidayInTheLab ... pictures of their chemistree, holiday sweaters, as well as ...
(Date:12/24/2014)... -- PharmaBoardroom,s new report, , Healthcare ... for free download , digs deep into this vibrant ... the sector today. One area where ... developing a homegrown pharmaceutical manufacturing base, even if the government,s ... way off. A cursory comparison with neighboring Morocco ...
(Date:12/24/2014)... and NEW YORK , ... from its open-label pilot study of mazindol in children ... Development and Therapy in December 2014 . ... mazindol in children with attention deficit/hyperactivity disorder" ( Konofal ... 2014 Dec 1;8:2321-2332. eCollection 2014 ) shows ...
Breaking Biology Technology:Worldwide Methyl Mercaptan Market 2015-2020 Forecasts on Development & Trends Now Available at ReportsnReports.com 2Major Pipette Distributor Pipette.com Announces their Holiday in the Lab Contest 2PharmaBoardroom Releases New Algeria Pharmaceuticals Report 2PharmaBoardroom Releases New Algeria Pharmaceuticals Report 3Redefining ADHD: A New Approach & A Shift of Paradigm in ADHD Therapeutics 2Redefining ADHD: A New Approach & A Shift of Paradigm in ADHD Therapeutics 3
... led by Professor Andre Geim, a recipient of the 2010 ... a flow of electrons can magnetise graphene. ... potentially huge breakthrough in the field of spintronics. Spintronics ... spin of the electron, in addition to its fundamental electric ...
... IRVINE, Calif., April 15, 2011 CryoLife, Inc. (NYSE: ... and cardiovascular tissue processing company, today announced it has ... of Cardiogenesis Corporation ("Cardiogenesis") to acquire only 49.9 percent ... On April 14, 2011, Cardiogenesis, CryoLife and CryoLife,s wholly-owned ...
... Therapeutics, a company that manufactures novel blood plasma-based biomaterials ... on a Series A financing it will use to ... early clinical validation for the Company,s first products. ... Capital Partners, a private investment firm that invests in ...
Cached Biology Technology:New spin on graphene 2CryoLife Amends Tender Offer Related to its Proposed Acquisition of Cardiogenesis Corporation 2CryoLife Amends Tender Offer Related to its Proposed Acquisition of Cardiogenesis Corporation 3CryoLife Amends Tender Offer Related to its Proposed Acquisition of Cardiogenesis Corporation 4CryoLife Amends Tender Offer Related to its Proposed Acquisition of Cardiogenesis Corporation 5CryoLife Amends Tender Offer Related to its Proposed Acquisition of Cardiogenesis Corporation 6CryoLife Amends Tender Offer Related to its Proposed Acquisition of Cardiogenesis Corporation 7Carmell Therapeutics Completes Series A Financing to Advance the Development of Novel Bioactive Plastics 2Carmell Therapeutics Completes Series A Financing to Advance the Development of Novel Bioactive Plastics 3
... Microarrays designed for RNA aptamer screening and ... and powerful Paraflo microfluidic on-chip synthesis platform. ... be synthesized on-chip and LC Sciences can ... microarrays are available as part of our ...
... a synthetic peptide whose sequence is from the C-terminal end of the ... extends from amino acids 429 to 448 of RAR*. The sequence ... - V - S - P - S - S - V ... - Q - S - P - L - L - Q ...
... The ELx50 is a fast and versatile ... with our patented Dual-ActionTM 16-channel manifold. This ... the dispense and aspiration manifolds for overfill ... and 384-well formats. The problem of fitting ...
... glutathione-S-transferase (GST) is commonly used as a ... coli (1). The GSTTag sequence has been ... some cases the solubility of its fusion ... folded form, GSTTag fusion proteins can be ...
Biology Products: