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Research breakthrough on the question of life expectancy
Date:8/5/2010

Why do we grow old and what can we do to stop it? This is the question asked by many, but it appears that we are now closer to an answer thanks to new research published by Monash University researcher Dr Damian Dowling.

According to the research published in the August edition of the prestigious journal, the American Naturalist, a small set of genes in mitochondria (a membrane-enclosed organelle found in most eukaryotic cells), passed only from mothers to offspring, plays a more dynamic role in predicting life expectancies than ever previously anticipated.

The research discovered that particular mitochondrial haplotypes were linked to the life expectancies of females in the beetle species Callosobruchus maculatus.

"What we found in these beetles that some combinations of mitochondrial and nuclear genomes confer long life in virgin females, but these are not the same combinations that result in long life in females that mate once, or in females that mate many times," Dr Dowling said.

"Clearly, the genetic determinants underlying life expectancies are complex.

"As we unravel this complexity, we draw closer to the day in which we might use the genetic information encoded in the mitochondria to assist in the development of therapies that slow the onset of ageing in humans," Dr Dowling said.

In animals, most of the genetic material that controls bodily functions is found inside the cell nucleus. This is the nuclear genome it is passed on from generation to generation through both mothers and fathers, and it encodes somewhere between 14 thousand and 40 thousand proteins.

However, a separate genome exists that is found only within the energy-producing factories of our cells the mitochondria. To put things in perspective, the mitochondrial genome is tiny, encoding just 13 proteins. Despite being so small, it can pack a punch when it comes to its ability to affect a range of fundamental biologi
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Contact: Megan Gidley
megan.gidley@monash.edu
61-039-903-4843
Monash University
Source:Eurekalert

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