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Research becomes a reality for Rett syndrome through new funding
Date:10/1/2010

Cincinnati, (OH) - The International Rett Syndrome Foundation (IRSF) announced today that it will award an additional $1.5M in research grants, bringing the 2010 total to $2.15 million for innovative basic and translational research that moves treatments for Rett syndrome a step closer to the clinic. IRSF is the world's largest private source of Rett syndrome research funding and with the addition of these awards the Foundation has cumulatively provided $23 million for Rett syndrome research.

Rett syndrome is an Autism Spectrum Disorder (ASD), characterized by distinguishing symptoms which begin to manifest in early childhood resulting in seriously debilitating neurological impairments in those affected. October 4th 2010 will mark 11 years since the landmark discovery, made in the laboratory of Dr. Huda Y. Zoghbi, that a single gene, MECP2, is responsible for the majority of cases of Rett syndrome. Since that time the pace of research has been rapid, resulting in recent work demonstrating genetic reversibility of the disease in mice. This year, regular research grant awards will be provided to the following exceptional scientific programs to further advance our understanding of the underlying causes of Rett syndrome:

  • "Pharmacological treatment of respiratory disorders in a mouse model of Rett syndrome", John M. Bissonnette, MD and Julian FR Paton, PhD, Oregon Health & Science University and the University of Bristol UK
  • "Epigenetic regulation of gene expression by MeCP2 in the mouse brain", Natalie G. Brub, PhD, University of Western Ontario
  • "Disruption of experience-dependent dendritic spine plasticity in MeCP2 mutant mice", Wen Biao Gan, PhD, New York University, School of Medicine
  • "Elucidation of Epigenetic Mechanisms in Rett Syndrome", Lisa Monteggia, PhD, University of Texas Southwestern Medical Center
  • "Using ChIA-PET to unravel high order chromatin regulatory functions of MeCP2", Yijun Ruan, PhD, The Genome Instit
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Contact: Stephen Bajardi
sbajardi@rettsyndrome.org
International Rett Syndrome Foundation
Source:Eurekalert

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