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Research at Argonne's Advanced Photon Source reveals structure and behavior of collagen
Date:2/26/2008

cancerous tumors or rheumatoid arthritis. The visualization of this interaction could help drug developers to create an inhibitor to prevent the pathological action of the enzyme, Orgel said.

Previous studies of the structure of collagen had looked only at crystals of small fragments of the protein, so scientists had little idea of how it looked within intact tissue.

Its impossible to get the information that we did by removing tiny chunks of the tissue, Orgel said. We couldnt obtain this data by single-crystal crystallography. This research was made possible only because of the BioCAT beamline provided by the APS.


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Contact: Steve McGregor
smcgregor@anl.gov
630-252-5580
DOE/Argonne National Laboratory
Source:Eurekalert

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