Navigation Links
Research at Argonne's Advanced Photon Source reveals structure and behavior of collagen
Date:2/26/2008

ARGONNE, Ill. (February 26, 2008) -- The structure and behavior of one of the most common proteins in our bodies has been resolved at a level of detail never before seen, thanks to new research performed at the Advanced Photon Source (APS) at the U.S. Department of Energys (DOE) Argonne National Laboratory.

Illinois Institute of Technology biologist Joseph Orgel used the high-energy X-rays produced by the APS to examine the structure of collagen, a protein that composes more than a quarter of all protein in the human body and forms the principal component of skin, teeth, ligaments, the heart, blood vessels, bones and cartilage. In these tissues, collagen molecules pack themselves into overlapping bundles called fibrils. These fibrils, which each contain billions of atoms, entwine themselves into collagen fibers that are visible to the naked eye.

Scientists have known the basic molecular structure of collagen since the 1950s, when several different international groups of scientists discovered that it had a triple-stranded helical structure. However, researches had never before had the ability to study the structure of an entire fibril in the same way that they could study an individual collagen molecule, according to Orgel.

Orgel and his team performed diffraction studies on intact collagen fibrils inside the tendons of rat tails in order to understand just how the protein functioned within unbroken tissue.

We tried to draw a highly accurate map of the molecular structure of tissues, Orgel said. By doing so, we hope to transform a very basic understanding that we have of the molecular structure of tissue into a much more tangible form.

Since the scientists kept the tendon tissue intact, they could see how the collagen molecule binds to collagenases, a class of enzymes which when working properly help to regulate the normal growth and development of animals but when malfunctioning can lead to the metastasis of
'/>"/>

Contact: Steve McGregor
smcgregor@anl.gov
630-252-5580
DOE/Argonne National Laboratory
Source:Eurekalert

Page: 1 2

Related biology news :

1. Rats on islands disrupt ecosystems from land to sea, researchers find
2. Iowa State researchers help piece together the corn genomes first draft
3. U-M researchers release most detailed global study of genetic variation
4. Haagen-Dazs gift to support Penn State honeybee research
5. LSU researchers challenge analyses on sustainability of Gulf fisheries
6. Researchers probe a DNA repair enzyme
7. Research uncovers the social dynamics of yellow jackets
8. New research reveals shark superhighways and hotspots
9. Managing uncertainty important in ecological balance: ASU researcher
10. Oregon researchers study widespread areas of low oxygen off northwest coast
11. Stanford researchers say living corals thousands of years old hold clues to past climate changes
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/22/2014)... antioxidants and can reduce free radical damage. ... oxidative stress? Jianbo Zhao and co-workers from ... University, China discovered that green tea polyphenol ... apoptosis, indicating green tea polyphenols play a ... oxidative stress. The relevant study has been ...
(Date:8/21/2014)... smog-producing toxins in past decade, GTA still violates ... that while the Greater Toronto Area (GTA) has ... to smog, the city continues to violate the ... can cause or aggravate health problems such as ... a set of complex photochemical reactions involving volatile ...
(Date:8/21/2014)... dandruff, eczema and other itchy, flaky maladies in humans ... Hawaiian coral reefs and the extreme environments of arctic ... the scientific journal PLOS Pathogens considers the ... genus Malassezia in light of new insights ... world. , University of Hawai,i at Mānoa scientist Anthony ...
Breaking Biology News(10 mins):Despite a significant reduction in smog-producing toxins, the Greater Toronto Area still violates Canada's standards for ozone air pollution 2From dandruff to deep sea vents, an ecologically hyper-diverse fungus 2
... for recent global warming and the rise in sea levels. ... found that this same increase in CO 2 may ... the planet,s most valuable ecosystemswetlands. The team,s findings are being ... Sciences the week of March 23. The team ...
... Mittermeier, renowned wildlife biologist and president of Conservation ... annual Roger Tory Peterson Medal presented by the ... deliver the Roger Tory Peterson Memorial Lecture on ... developing criteria for biodiversity "hotspots" as a conservation ...
... CellThera, a biotechnology company located in Worcester Polytechnic ... Park, has received a contract from the U.S. ... its research program in tissue regeneration. Under the ... of WPI,s Bioengineering Institute (BEI), and the university ...
Cached Biology News:Scientists find climate change to have paradoxical effects in coastal wetlands 2Scientists find climate change to have paradoxical effects in coastal wetlands 3Wildlife biologist named Roger Tory Peterson Medal recipient, speaker 2CellThera and WPI advance in regeneration study 2
(Date:8/22/2014)... “Our nation's healthcare system is ... disgrace. Furthermore, every governmental and professional entity that ... state of unorganized dysfunction shares in that enormous ... serve as a device to use in an ... that have accumulated through the years leading to ...
(Date:8/21/2014)... international research team including DESY scientists has observed tiny ... team reports in the journal Science that ... inside the nanodroplets. It is the first time that ... larger samples of what is known as superfluid helium, ... our best expectations," says Andrey Vilesov of the University ...
(Date:8/21/2014)... COLD SPRING, N.Y. , Aug. 21, 2014 ... today the launch of their Nutraceutical "TELO-20 for ... first and only Telomere-lengthening supplement in the world ... the ends of every chromosome in the body. ... the world,s leading experts in Telomere Science and ...
(Date:8/21/2014)... 21, 2014 OTC Markets Group ... a biotechnology company, on its approval to list ... on OTCQX®, the best marketplace for established U.S. ... Logo - http://photos.prnewswire.com/prnh/20110118/MM31963LOGO ... execution of its growth strategy and achievement of ...
Breaking Biology Technology:5 Great Mistakes in Healthcare and How to Fix Them by Dr. Ira Williams 2Scientists observe quantum vortices in cold helium droplets 2Telomere Biosciences Announces: TELO-20 for Dogs, the World's First Telomere-Lengthening Supplement for Dogs, to Promote Healthy Aging and Longevity 2Telomere Biosciences Announces: TELO-20 for Dogs, the World's First Telomere-Lengthening Supplement for Dogs, to Promote Healthy Aging and Longevity 3OTC Markets Group Congratulates Immune Pharmaceuticals on NASDAQ Listing 2
... ... Drug safety specialty firm BioSoteria announced that its Vice President ... Performance™ (CPLP) credential from the American Society for Training and Development ... of medical communications and health care training experience and is responsible ...
... ... of interest to anyone working in continuous flow chemistry processing, will deal with the application ... Professor Ley,s work of over 670 publications has been recognized with several prestigious prizes ... ...
... , PETERSBURG, Va., Nov. 4 Star Scientific, ... the company plans to introduce the CigRx(TM) nutraceutical product developed ... sales in partnership with inVentiv Health, Inc ... of commercialization solutions for every stage of the product lifecycle, ...
Cached Biology Technology:BioSoteria eLearning Executive Michelle Nolin Flewell Earns Certification 2BioSoteria eLearning Executive Michelle Nolin Flewell Earns Certification 3BioSoteria eLearning Executive Michelle Nolin Flewell Earns Certification 4Professor Steven Ley of University of Cambridge will Present Free Webinar, 'Application of the ReactIR Flow Cell to Continuous Processing Technology' 2Professor Steven Ley of University of Cambridge will Present Free Webinar, 'Application of the ReactIR Flow Cell to Continuous Processing Technology' 3Star Scientific Plans Worldwide Marketing and Sales of CigRx(TM) Nutraceutical in Partnership with inVentiv Health 2Star Scientific Plans Worldwide Marketing and Sales of CigRx(TM) Nutraceutical in Partnership with inVentiv Health 3Star Scientific Plans Worldwide Marketing and Sales of CigRx(TM) Nutraceutical in Partnership with inVentiv Health 4
geminin, DNA replication inhibitor...
Normal human serum, single donor...
One-step, microplate or cuvet, colorimetric, linear detection range 0.1 mg/dL to 100 mg/dL. Procedure: 20 min....
... Certified USDA Research Registered OLAW Assured AAALAC ... AALAS Certified Technicians Documentation ... Upon Request Focus CRP is ... your custom immunology service needs. We ...
Biology Products: