Navigation Links
Research at Argonne's Advanced Photon Source reveals structure and behavior of collagen
Date:2/26/2008

ARGONNE, Ill. (February 26, 2008) -- The structure and behavior of one of the most common proteins in our bodies has been resolved at a level of detail never before seen, thanks to new research performed at the Advanced Photon Source (APS) at the U.S. Department of Energys (DOE) Argonne National Laboratory.

Illinois Institute of Technology biologist Joseph Orgel used the high-energy X-rays produced by the APS to examine the structure of collagen, a protein that composes more than a quarter of all protein in the human body and forms the principal component of skin, teeth, ligaments, the heart, blood vessels, bones and cartilage. In these tissues, collagen molecules pack themselves into overlapping bundles called fibrils. These fibrils, which each contain billions of atoms, entwine themselves into collagen fibers that are visible to the naked eye.

Scientists have known the basic molecular structure of collagen since the 1950s, when several different international groups of scientists discovered that it had a triple-stranded helical structure. However, researches had never before had the ability to study the structure of an entire fibril in the same way that they could study an individual collagen molecule, according to Orgel.

Orgel and his team performed diffraction studies on intact collagen fibrils inside the tendons of rat tails in order to understand just how the protein functioned within unbroken tissue.

We tried to draw a highly accurate map of the molecular structure of tissues, Orgel said. By doing so, we hope to transform a very basic understanding that we have of the molecular structure of tissue into a much more tangible form.

Since the scientists kept the tendon tissue intact, they could see how the collagen molecule binds to collagenases, a class of enzymes which when working properly help to regulate the normal growth and development of animals but when malfunctioning can lead to the metastasis of cancerous tumors or rheumatoid arthritis. The visualization of this interaction could help drug developers to create an inhibitor to prevent the pathological action of the enzyme, Orgel said.

Previous studies of the structure of collagen had looked only at crystals of small fragments of the protein, so scientists had little idea of how it looked within intact tissue.

Its impossible to get the information that we did by removing tiny chunks of the tissue, Orgel said. We couldnt obtain this data by single-crystal crystallography. This research was made possible only because of the BioCAT beamline provided by the APS.


'/>"/>

Contact: Steve McGregor
smcgregor@anl.gov
630-252-5580
DOE/Argonne National Laboratory
Source:Eurekalert

Related biology news :

1. Rats on islands disrupt ecosystems from land to sea, researchers find
2. Iowa State researchers help piece together the corn genomes first draft
3. U-M researchers release most detailed global study of genetic variation
4. Haagen-Dazs gift to support Penn State honeybee research
5. LSU researchers challenge analyses on sustainability of Gulf fisheries
6. Researchers probe a DNA repair enzyme
7. Research uncovers the social dynamics of yellow jackets
8. New research reveals shark superhighways and hotspots
9. Managing uncertainty important in ecological balance: ASU researcher
10. Oregon researchers study widespread areas of low oxygen off northwest coast
11. Stanford researchers say living corals thousands of years old hold clues to past climate changes
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:2/2/2016)... Feb. 2, 2016 Technology Enhancements Accelerate Growth of ... of the digital and computed radiography markets in ... and Indonesia (TIM). It provides ... size, as well as regional market drivers and restraints. ... market penetration and market attractiveness, both for digital and ...
(Date:2/1/2016)... 2016  Today, the first day of American Heart ... develop a first of its kind workplace health solution ... In the first application of Watson ... ), and Welltok will create a new offering that ... analytics, delivered on Welltok,s health optimization platform. The effort ...
(Date:1/25/2016)... BLUE BELL, Pa. , Jan. 25, 2016   Unisys ... facial recognition system at John F. Kennedy (JFK) International Airport, ... and Border Protection (CBP) identify imposters attempting to enter ... or do not belong to them. pilot testing ... rolled out initially at three terminals at JFK during January 2016. ...
Breaking Biology News(10 mins):
(Date:2/5/2016)... , February 5, 2016 Amarantus ... biotechnology company focused on developing products for Regenerative Medicine, ... Rare Pediatric Disease Designation (RPDD) from the US Food ... with MANF. MANF was previously granted orphan drug designation ... --> Amarantus BioScience Holdings, Inc. (OTCQB: ...
(Date:2/4/2016)... ... February 04, 2016 , ... Shimadzu Scientific Instruments will showcase ... demos and poster sessions, and present on the analysis of mycotoxins and medical ... 6 to 10 at the Georgia World Congress Center in Atlanta, Georgia. ...
(Date:2/4/2016)... YORK , February 4, 2016 ... QBIO), a biotechnology acceleration company is pleased to provide the ... --> Over the last 3 months we ... and securities purchase agreements exceeding $1,000,000. As a result, we ... our Mannin Research Inc. license agreement and expect that development ...
(Date:2/4/2016)... England , February 4, 2016 ... Bioscience Laboratories (ABL), Inc. --> Strasbourg, France ... Inc. --> PharmaVentures is pleased to announce that ... of its biopharmaceutical manufacturing unit in Strasbourg, France ... Inc. --> --> Transgene ...
Breaking Biology Technology: