Navigation Links
Reprogramming stem cells to a more basic form results in more effective transplant, study shows
Date:11/2/2011

This release is also available in Chinese on EurekAlert! Chinese.

Durham, NC November 2011 Chinese stem cell scientists have published new research that improves the survival and effectiveness of transplanted stem cells. The research led by Dr Hsiao Chang Chan, from the Chinese University of Hong Kong, is published in Stem Cells.

Research into differentiation has led to a variety of breakthroughs as stem cell researchers harvest cells from one part of the body and genetically adapt them to fulfill a specialized role. However, if the implanted cells are too much like the cells of the targeted area they may not have the plasticity to engraft and repair the injured tissue.

"Stem cell differentiation and transplantation has been shown to improve function in conditions including degenerative diseases and blood supply disorders," said Dr Chan. "However, the survival rate of transplanted cells in patients limits their overall effectiveness, which is a barrier to clinical use."

To overcome this issue Dr Chan's team explored de-differentiation, a process that reverts specialized, differentiated cells back to a more primitive cell.

The team focused their research on multipotent stem cells, (MSCs) which can be altered into a variety of cell types through differentiation. Bone marrow MSCs have the potential to differentiate into each of the three basic types of lineage cells which form bone (osteocytes), cartilage (chondrocytes) and fat tissue (adipocytes).

The team first differentiated bone marrow MSCs towards a neuronal lineage, but then removed the differentiation conditions, allowing the cell to revert back to a form with more basic cellular characteristics.

Following this process the team recorded increased cell survival rates following
'/>"/>

Contact: Ben Norman
Lifesciencenews@wiley.com
44-124-377-0375
Wiley-Blackwell
Source:Eurekalert

Page: 1 2

Related biology news :

1. Yamanaka eliminates viral vector in stem cell reprogramming
2. Reprogramming human cells without inserting genes
3. Tumor suppressor pulls double shift as reprogramming watchdog
4. Fate Therapeutics announces creation of small molecule platform for commercial-scale reprogramming
5. Massachusetts General Hospitals Warren Triennial Prize to honor pioneers of cellular reprogramming
6. Plasticity of hormonal response permits rapid gene expression reprogramming
7. Jefferson scientists deliver toxic genes to effectively kill pancreatic cancer cells
8. NSF funds new Center for the Physics of Living Cells at Illinois
9. When cells go bad
10. The role of stem cells in renewing the cornea
11. Breast cancer cells recycle to escape death by hormonal therapy
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/18/2014)... millions of Americans to undertake jaunts into the countryside each ... longer within a century, according to new research. , Climate ... the United States as summer temperatures linger later into the ... Ecology and Biogeography . For instance, the paper birch ... New Hampshire could change color one to three weeks ...
(Date:9/18/2014)... colleagues have built the first smartphone app that ... behavioral trends. In other words, your smartphone knows ... don,t -- and how that affects you. , ... depression and loneliness to their academic performance, also ... for example, to monitor mental health, trigger intervention ...
(Date:9/18/2014)... seem to be cheerful, happy-go-lucky characters, so you might ... life. , In fact some dogs are distinctly ... Sydney shows. , "This research is exciting because ... objectively and non-invasively. It offers researchers and dog owners ... that changes," said Dr Melissa Starling, from the Faculty ...
Breaking Biology News(10 mins):Fall foliage season may be later, but longer on warmer Earth 2Fall foliage season may be later, but longer on warmer Earth 3Fall foliage season may be later, but longer on warmer Earth 4New Dartmouth smartphone app reveals users' mental health, performance, behavior 2New Dartmouth smartphone app reveals users' mental health, performance, behavior 3New Dartmouth smartphone app reveals users' mental health, performance, behavior 4Dogs can be pessimists too 2Dogs can be pessimists too 3
... Mich. A new study finds that African ancestry ... type of cancer that has fewer treatment options. ... found that, among women with breast cancer, 82 percent ... African-Americans were and 16 percent of white Americans were. ...
... crocodiles and navigating around massive submerged trees, a team ... pools of Cara Blanca, Belize, which were important to ... divers found fossilized animal remains, bits of pottery and ... underwater cave. [Click here to see a ...
... years ago when the American Society for Cell Biology (ASCB) ... This year over 7,000 scientists from throughout the world ... Dec. 11 to 15 for ASCB,s 50th Annual Meeting. ... research on the cell, ASCB,s conferences are the largest yearly ...
Cached Biology News:Study links African ancestry to high-risk breast cancer 2Extreme archaeology: Divers plumb the mysteries of sacred Maya pools 2Extreme archaeology: Divers plumb the mysteries of sacred Maya pools 3Cell biology society celebrates 50th 2
(Date:9/19/2014)... 2014 Cereal grain scientists, quality ... gather October 5–8, 2014, for the AACC International ... Center in Providence, Rhode Island. The comprehensive scientific ... food scientists, chemists, microbiologists, nutritionists, and those interested ... management. To date, 1,000 attendees have registered for ...
(Date:9/18/2014)... Washington, USA (PRWEB) September 18, 2014 ... Representatives of a bill designed to stimulate development and ... jobs is being praised by leaders of SPIE, ... bill, the Revitalizing American Manufacturing and Innovation (RAMI) Act, ... The bill’s authors have said they are optimistic that ...
(Date:9/18/2014)... 2014 A novel robotic system that ... is currently being tested as part of a biomedical ... Boston with the aim of determining if the robot, ... cancer biopsies faster, more accurate, less costly, and less ... the potential to deliver prostate cancer therapies with greater ...
(Date:9/18/2014)... On Tuesday, Secretary of Energy Ernest Moniz joined ... Lab Day on the Hill. The event highlighted several ... Durbin and Risch also formally launched the Senate National ... reach of the national labs as leaders in developing ... our nation's most pressing challenges. , "The national labs ...
Breaking Biology Technology:Latest Research on Cereal Grain Quality, Health Benefits and Food Production to be Presented During the AACC International Annual Meeting 2Latest Research on Cereal Grain Quality, Health Benefits and Food Production to be Presented During the AACC International Annual Meeting 3House passage of high-tech manufacturing bill is move toward stronger economy, say SPIE leaders 2House passage of high-tech manufacturing bill is move toward stronger economy, say SPIE leaders 3Worcester Polytechnic Institute Participates in Clinical Trial for MRI-Compatible Robot Designed to Improve Accuracy of Prostate Cancer Biopsies 2Worcester Polytechnic Institute Participates in Clinical Trial for MRI-Compatible Robot Designed to Improve Accuracy of Prostate Cancer Biopsies 3Worcester Polytechnic Institute Participates in Clinical Trial for MRI-Compatible Robot Designed to Improve Accuracy of Prostate Cancer Biopsies 4Worcester Polytechnic Institute Participates in Clinical Trial for MRI-Compatible Robot Designed to Improve Accuracy of Prostate Cancer Biopsies 5Worcester Polytechnic Institute Participates in Clinical Trial for MRI-Compatible Robot Designed to Improve Accuracy of Prostate Cancer Biopsies 6Lab Day Highlight Labs' Contribution to U.S. Competitiveness and Innovation 2Lab Day Highlight Labs' Contribution to U.S. Competitiveness and Innovation 3
... ATLANTA, Sept. 29, 2011 GeoVax Labs, Inc. (OTCQB/OTCBB: ... and fight Human Immunodeficiency Virus (HIV) infections, announces that ... to receive academic honors on September 26 and October ... Officer Harriet L. Robinson, PhD, was honored as a ...
... as a symbol of long-lasting love. But semiconductor makers ... of long-lasting micromachines if a new method developed at ... carving these tough, capable crystals proves its worth.* The ... in a diamond surface, yielding potential benefits in both ...
... PLC (AIM: GTL) today conducted its annual meeting in London, ... Henderson, the non-executive chairman of the U.S. based bio-refining company, ... "GTL is pleased to report that margins ... period ending September 30, 2011 closely tracked the seasonal margins ...
Cached Biology Technology:GeoVax Labs' CSO and Chairman Receive Academic Honors 2GeoVax Labs' CSO and Chairman Receive Academic Honors 3NIST polishes method for creating tiny diamond machines 2
CD69/CD3 50 tests...
PURA Immunogen: PURA (NP_005850, 183 a.a. ~ 293 a.a) partial recombinant protein with GST tag. Storage: -20 C, Avoid Freeze/Thaw Cycles *Available for distribution in the US only...
Rat polyclonal to Vitamin B3 ( Abpromise for all tested applications). Antigen: Chemical / Small Molecule, Vitamin B3 conjugated to BSA....
Goat polyclonal to Glucose Dehydrogenase ( Abpromise for all tested applications). Antigen: Glucose Dehydrogenase (Bacillus species)...
Biology Products: