Navigation Links
Reprogrammed stem cells hit a roadblock
Date:2/20/2011

ammed cells exhibit a "genomic instability" that appears to be caused by the process used to return the cells to their embryonic state. Even more serious, the genetic mutations observed resemble mutations that are found in cancer cells. The scientists draw the conclusion that reprogrammed stem cells need to be extensively investigated before they can even be considered for use in regenerative medicine.

The experiments were done using mouse mammary and fibroblast cells. The researchers used three different processes for reprogramming the cells to a "stem," or embryonic, state. The first method was developed expressly for this study, and the others have already been well documented.

Yet all the processes led to the same, implacable conclusion: the genetic anomalies multiplied, in a manner that seems to indicate that they are inherent to the reprogramming process itself, which typically makes use of oncogenes. "Interestingly, oncogenes have the potential to induce genomic instability," the authors explain.

These results underline the necessity of conducting further studies. First, to see if the genetic anomalies are serious enough to compromise the function and stability of cells regenerated using the reprogrammed cells; and second, to "refine the methods used for generating induced pluripotent cells, in order to avoid this problem. These results will thus motivate scientists to come up with a solution," concludes Trono.


'/>"/>

Contact: Emmanuel Barraud
emmanuel.barraud@epfl.ch
41-216-932-190
Ecole Polytechnique Fdrale de Lausanne
Source:Eurekalert

Page: 1 2

Related biology news :

1. FDA funds pediatric trial testing genetically reprogrammed HSV to treat cancer
2. Genetically reprogrammed HSV given systemically shrinks distant sarcomas
3. Reprogrammed human blood cells show promise for disease research
4. Study reveals a reprogrammed role for the androgen receptor
5. Study finds blood cells can be reprogrammed to act as embryonic stem cells
6. Researchers piggyback to safer reprogrammed stem cells
7. Stanford researchers develop new technology for cheaper, more efficient solar cells
8. Sleeping Trojan horse to aid imaging of diseased cells
9. Living in the matrix: Sugar residues regulate growth and survival of nerve cells
10. Clay-armored bubbles may have formed first protocells
11. MicroRNA cocktail helps turn skin cells into stem cells
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:8/29/2014)... - The rise of the Tibetan plateau -- the ... is important for both its profound effect on climate ... published in GSA Bulletin , Katharine Huntington and ... thermometry -- using modern and fossil snail shells to ... southwestern Tibet. , Views range widely on the ...
(Date:8/28/2014)... is pleased to announce the selection of Dr. Fred ... Membership acknowledges those who have served ESA for at ... of the Society that has reached an extraordinary level. ... Governing Board and then voted on by the ESA ... Ceremony at Entomology 2014, ESA,s Annual Meeting in Portland, ...
(Date:8/28/2014)... A new study reports that an expansion of marine ... perform key ecological functions. According to investigators from ... at protecting fish have focused on saving the largest ... species that provide key and difficult-to-replace ecological functions. ... are performed by fish species that also are food ...
Breaking Biology News(10 mins):Snails tell of the rise and fall of the Tibetan Plateau 2Snails tell of the rise and fall of the Tibetan Plateau 3Snails tell of the rise and fall of the Tibetan Plateau 4Snails tell of the rise and fall of the Tibetan Plateau 5Snails tell of the rise and fall of the Tibetan Plateau 6Snails tell of the rise and fall of the Tibetan Plateau 7Fred Baxendale selected as Honorary Member of the Entomological Society of America 2Study finds marine protected areas inadequate for protecting fish and ocean ecology 2
... the intricate structure of cartilage in what they hope will ... one day be treated. , The disease, which affects more ... the wear and tear of the smooth, hard cartilage tissue ... over one another at the joint. , Scientists have ...
... common chemical found in everything from plastics to soaps, ... for the first time, is linked to abdominal obesity ... study by the University of Rochester Medical Center. , ... exposures to phthalates and other common chemicals may be ...
... week of February 12 in an online edition of ... significant insights into normal folding mechanisms as well as ... new insights may lead to the discovery of novel ... and amyloids can play beneficial roles. The subject of ...
Cached Biology News:Cartilage discovery offers arthritis hope 2Phthalates now linked to fat, related health risks 2Scripps research study reveals structural dynamics of single prion molecules 2Scripps research study reveals structural dynamics of single prion molecules 3
(Date:8/28/2014)... A new research platform uses a ... tiny structures undergoing stress and heating, an ... designs for microelectronics and batteries., This new ... about how heating and the surface stress ... Researchers have discussed the merits of surface-stress ...
(Date:8/28/2014)... Willow Grove, PA (PRWEB) August 28, 2014 ... talent, and create a culture that will allow individuals ... that are becoming increasingly important for employers looking to ... life science industries are embracing this trend, as the ... the fabric of a company, which will have real ...
(Date:8/28/2014)... 28, 2014 Sterlitech is proud to ... to its stable of products . These ... cut-offs and include membrane filters with surface charges. ... customer demand for our membrane process testing equipment, and ... flat sheet membranes,” explains Sterlitech President Mark Spatz. ...
(Date:8/28/2014)... Scientists, researchers, and technologists will converge ... Damage 2014 symposium. Marking its 46th year, the ... run 14-17 September. The event is sponsored by ... , The premier conference for basic and applied issues ... materials will engage researchers and engineers from numerous industries ...
Breaking Biology Technology:New analytical technology reveals 'nanomechanical' surface traits 2New analytical technology reveals 'nanomechanical' surface traits 3Klein Hersh International Leads Philadelphia Area Life Science Industry in Company Culture 2Klein Hersh International Leads Philadelphia Area Life Science Industry in Company Culture 3Sterlitech Corporation Enhances Its Selection of Flat Sheet Membrane Filters 2Laser Damage to Draw Researchers, Engineers, Scientists to 46th Annual Conference 2Laser Damage to Draw Researchers, Engineers, Scientists to 46th Annual Conference 3
... unmatched out-of-the-box functionality, BENSALEM, Pa., Oct. ... market leader in providing enterprise-wide,compliance solutions to ... System (QMS) module for Livelink ECM from ... Enterprise Content,Management (ECM) software and solutions. QMS ...
... investors and professionals to share ... sector, FARMINGTON HILLS, Mich., Oct. 18 ... timely information on the,biotechnology sector has expanded its ... the launch of The Biotech Forums. Within,The Biotech ...
... a,biodiagnostics company specializing in glycan biomarkers for diagnosis ... today the,appointment of Dr. Chen Even as Chairman ... board member since 2004, contributes more than a,decade ... very pleased to elevate Dr. Even to the ...
Cached Biology Technology:Stelex Announce QMS Module for Open Text's Livelink ECM 2Stelex Announce QMS Module for Open Text's Livelink ECM 3BiotechWatch Launches The Biotech Forum 2Glycominds Appoints Board of Directors Chairman 2Glycominds Appoints Board of Directors Chairman 3
... is a new product number, ... product number. If showing no ... the old Sigma-Aldrich number (Z71,670-7) ... assistance. ID clarifier: non-barcoded Mfr ...
... kit provides complete components including positive and ... DNA fragmentation in cultured cells and tissue ... procedure provides greater sensitivity than biotinylated or ... flow cytometry. The kit works well with ...
... Whatever your Ion Chromatography requirements, ... more . The newly developed ... sensitivities and exceptionally ultra-low drift . ... regeneration suppression creates even higher ...
... other fluid sources for 8 vessels while ... each individual pump is controlled electronically. Both, ... maintained. ,High-precision controlled miniature pumps can ... allows flow rates between 0 and 420 ...
Biology Products: