Navigation Links
Reprogrammable cell type depends on a single gene to keep its identity
Date:12/1/2008

r, Ph.D., a member of the St. Jude Department of Genetics and Tumor Cell Biology. Differentiation is the process by which genetic activity causes an immature cell type to acquire specific characteristics of a particular mature adult cell type.

"In the last few years, some discoveries have challenged the long-standing belief that cell differentiation is an irreversible final process," said Oliver, the paper's senior author. "St. Jude researchers showed that lymphatic endothelial cells are one of the few examples of differentiated cell types that require constant expression of a specific gene to maintain their identity. This current work builds on our previous results that demonstrated the key role Prox1 plays in the formation of the lymphatic vasculature."

As an important resource for this finding, Oliver's team used a special mouse strain in which the Prox1 genes could be deleted from LECs at different times during development or after birth.

The St. Jude team found that deletion of Prox1 in LECs promoted their reprogramming into BECs as indicated by the expression of specific LEC and BEC proteins. In addition, the newly reprogrammed cells gained some specific features typical of blood vessels. For example, the cells were surrounded by pericytessmall cells that help support endothelial cellsand blood abnormally entered the reprogrammed mutant lymphatic vessels.

Finally, the researchers used a trick that enabled them to block the ability of isolated cultured LECs to produce the Prox1 proteins to further demonstrate that Prox1 activity is required by LECs to maintain their identity.

"The new insights offered by this research will give us a better understanding of how to convert one cell into another and the eventual use of the new therapeutic approaches in pathological conditions and tumors," Oliver said.


'/>"/>

Contact: Summer Freeman
summer.freeman@stjude.org
901-595-3061
St. Jude Children's Research Hospital
Source:Eurekalert

Page: 1 2

Related biology news :

1. Environmental fate of nanoparticles depends on properties of water carrying them
2. Nature study demonstrates that bacterial clotting depends on clustering
3. Model for the assembly of advanced, single-molecule-based electronic components developed at Pitt
4. Single-largest biodiversity survey says primary rainforest is irreplaceable
5. New technique captures chemical reactions in a single living cell at unprecedented resolution
6. Gene study supports single main migration across Bering Strait
7. Baumann lab identifies elusive telomere RNA subunit in single cell model
8. Ebola virus disarmed by excising a single gene
9. Blue-eyed humans have a single, common ancestor
10. Rice scientists make breakthrough in single-molecule sensing
11. Single-celled bacterium works 24-7
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/19/2014)... -- Nxt-ID, Inc. (Nasdaq: NXTD and NXTDW) ("Nxt-ID" ... m-commerce market, updates the "Wocket in Your Pocket" celebrity ad campaign, ... middleweight weight classes, Vinny Pazienza (PAZ). ... of Thrones actor Ciaran Hinds and Sons ... Katey Sagal have been cast in Bleed for This ...
(Date:9/18/2014)... University researchers have developed a unique method to use ... in rural areas. , The first microbe-powered, self-sustaining ... quick way to clean up waste from large farming ... , Professor Haluk Beyenal and graduate student Timothy ... discuss the system in the online edition of ...
(Date:9/18/2014)... BUFFALO, N.Y. A sleep-promoting circuit located deep in ... deep sleep. Discovered by researchers at Harvard School of ... and Biomedical Sciences, this is only the second "sleep ... to be both necessary and sufficient to produce deep ... Neuroscience , the study demonstrates that fully half of ...
Breaking Biology News(10 mins):NXT-ID's Vinny Paz Celebrity Ad Wocket Update: Katey Sagal and Ciaran Hinds Attached to His Upcoming Movie 2NXT-ID's Vinny Paz Celebrity Ad Wocket Update: Katey Sagal and Ciaran Hinds Attached to His Upcoming Movie 3Researchers develop unique waste cleanup for rural areas 2No sedative necessary: Scientists discover new 'sleep node' in the brain 2
... naturalist Charles Darwin on the Galapagos Islands, researchers have ... on a particular island, can lead to the formation ... Natural selection is a process whereby heritable traits ... while unfavorable heritable traits become less common. Over time, ...
... spider silk. Stretch it. Bend it. Soak it. Dry it out. ... and can expand nearly a third greater than its original length ... stronger than Kevlar, the man-made fiber used in bulletproof vests. ... is to know about the remarkable physics of spider silk, but ...
... Preserving genetically diverse local crops in areas where small-scale ... Penn State geographer, who is part of an international ... in hotspots of Bolivia, Peru and Mexico. Hotspots ... crops has exploded over the past decade, noted Karl ...
Cached Biology News:LSU professor discovers how new corals species form in the ocean 2LSU professor discovers how new corals species form in the ocean 3Stanford researcher sheds new light on the mysteries of spider silk 2Stanford researcher sheds new light on the mysteries of spider silk 3Stanford researcher sheds new light on the mysteries of spider silk 4Preserving biodiversity can be compatible with intensive agriculture 2Preserving biodiversity can be compatible with intensive agriculture 3
(Date:9/18/2014)... Sept. 18, 2014 About POCT ... performed outside a clinical laboratory. It helps in ... appropriate treatments and medication. POCT is gaining popularity ... lifestyle diseases such as diabetes, heart disease, and ... devices are standardized to minimize errors during the ...
(Date:9/18/2014)... 18, 2014 A novel robotic system ... scanner is currently being tested as part of a ... in Boston with the aim of determining if the ... prostate cancer biopsies faster, more accurate, less costly, and ... has the potential to deliver prostate cancer therapies with ...
(Date:9/18/2014)... DUBLIN, Ireland , September 18, ... ,Research and Markets ( http://www.researchandmarkets.com/research/czvg3s/biocompatible ) ... "Biocompatible Materials - Global Strategic ... offering. ,     (Logo: http://photos.prnewswire.com/prnh/20130307/600769) ,This report ... Materials in US$ Million by the ...
(Date:9/18/2014)... 2014 On Tuesday, Secretary of Energy ... Risch for National Lab Day on the Hill. The ... national laboratory system. Durbin and Risch also formally launched ... awareness of the reach of the national labs as ... address some of our nation's most pressing challenges. , ...
Breaking Biology Technology:POCT Market in China 2014-2018 2Worcester Polytechnic Institute Participates in Clinical Trial for MRI-Compatible Robot Designed to Improve Accuracy of Prostate Cancer Biopsies 2Worcester Polytechnic Institute Participates in Clinical Trial for MRI-Compatible Robot Designed to Improve Accuracy of Prostate Cancer Biopsies 3Worcester Polytechnic Institute Participates in Clinical Trial for MRI-Compatible Robot Designed to Improve Accuracy of Prostate Cancer Biopsies 4Worcester Polytechnic Institute Participates in Clinical Trial for MRI-Compatible Robot Designed to Improve Accuracy of Prostate Cancer Biopsies 5Worcester Polytechnic Institute Participates in Clinical Trial for MRI-Compatible Robot Designed to Improve Accuracy of Prostate Cancer Biopsies 6Biocompatible Materials - Global Strategic Business Report 2014 2Biocompatible Materials - Global Strategic Business Report 2014 3Lab Day Highlight Labs' Contribution to U.S. Competitiveness and Innovation 2Lab Day Highlight Labs' Contribution to U.S. Competitiveness and Innovation 3
... Sky One,Medical, Inc. ("China Sky One Medical" or ... integrated pharmaceutical company producing over-the-counter,drugs in the People,s ... production at Peng Lai Jin Chuang Company ("Jin ... 14, 2008., Jin Chuang, a subsidiary of ...
... (Nasdaq: NLTX ), today announced interim data from its ... natriuretic,peptide, in patients hospitalized for acute heart failure., ... pressure -- Statistically significant ... right atrial pressure -- Trend toward increase in ...
... Va., Oct. 14 Insmed Inc. (Nasdaq,CM: INSM), a ... will seek shareholder approval to implement a reverse,stock split, ... November,24, 2008, in an effort to meet the minimum ... Market., On September 3, 2008, the Company announced ...
Cached Biology Technology:China Sky One Medical, Inc. Starts Production at Newly Acquired Facility and Reaffirms Guidance 2China Sky One Medical, Inc. Starts Production at Newly Acquired Facility and Reaffirms Guidance 3Nile Therapeutics Announces Positive Interim Data from Phase 2a Study of CD-NP in Patients with Heart Failure 2Nile Therapeutics Announces Positive Interim Data from Phase 2a Study of CD-NP in Patients with Heart Failure 3Nile Therapeutics Announces Positive Interim Data from Phase 2a Study of CD-NP in Patients with Heart Failure 4Nile Therapeutics Announces Positive Interim Data from Phase 2a Study of CD-NP in Patients with Heart Failure 5Insmed to Seek Shareholder Approval for Reverse Split 2Insmed to Seek Shareholder Approval for Reverse Split 3
Cell Culture Flask, 175 cm, tissue-culture treated polystyrene, barcoded...
... an aqueous solution that contains a purified ... a PBS buffer (phosphate buffered saline), pH ... a combination of 0.02% methylisothiazolone and 0.02% ... Stabilizer provides optimum performance for both microsphere ...
... clone K28/86.2, PDZ Domain GenBank ... : GST fusion to residues 77-299 ... Tris pH 7.4, 0.075M NaCl containing ... evaluated by immunoblot on rat brain ...
... The ProteoPrep 20 Plasma Immunodepletion Kit ... proteins from human plasma or serum in ... enables deeper penetration into the plasma proteome ... single or multidimensional chromatography or go straight ...
Biology Products: