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Reproductive scientists create mice from 2 fathers
Date:12/8/2010

be valuable for preserving species when no females remain.

In the future, it may also be possible to generate human oocytes from male iPS cells in vitro. Used in conjunction with in vitro fertilization, this would eliminate the need for female XO/XX chimeras, although a surrogate mother would still be needed to carry the two-father pregnancy to term.

Using a variation of the iPS technique, the researchers say "it may also be possible to generate sperm from a female donor and produce viable male and female progeny with two mothers."

The authors also caution that the "generation of human iPS cells still requires significant refinements prior to their use for therapeutic purposes."


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Contact: Dr. Richard R. Behringer
rrb@mdanderson.org
713-634-6337
Society for the Study of Reproduction
Source:Eurekalert

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