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Reportlinker Adds Global Biochip Markets: Microarrays and Lab-on-a-Chip
Date:12/14/2010

TRODUCTION 137

DRIVING FORCES FOR ADOPTION OF BIOCHIP DIAGNOSTIC PLATFORMS 137

BIOMARKER DISCOVERY AND VALIDATION 137

CLINICAL ACCEPTANCE OF BIOMARKER-BASED TESTS 138

TABLE 60 RATE OF ADOPTION OF DNA MICROARRAY DIAGNOSTICS TESTS 139

MICROARRAY STANDARDIZATION EFFORTS 140

Microarray Quality Control Project 140

External RNA Controls Consortium (ERCC) Study 141

Association of Bimolecular Resource Facilities (ABRF) CGH Microarray Platform Study 142

TABLE 61 COMPARISON OF ARRAY-CGH PLATFORMS 142

OVERVIEW OF MDX 143

INTRODUCTION 143

BENEFITS OF BIOCHIPS AS AN MDX PLATFORM 144

Benefits of Biochips as an MDX Platform (Continued) 145

FIGURE 23 BIOCHIPS TARGET HIGH GROWTH, HIGH MARGIN PORTION OF THE IVD MARKET 146

TABLE 62 BIOTECHNOLOGY DRUGS APPROVED BY THE FDA, 1980–2008 (NUMBER) 147

PHARMACOGENOMICS TESTS 147

Pharmacogenomics Tests (Continued) 148

STRATEGIES FOR COMMERCIALIZING PGX TESTS 149

MDX MARKET PENETRATION CHALLENGES 150

TABLE 63 COMPARISON OF DNA-BASED MDX PLATFORMS 151

TABLE 64 FACTORS AFFECTING PENETRATION OF BIOCHIPS INTO THE MDX MARKET 152

MDX Market Penetration Challenges (Continued) 153

MDX MARKET SEGMENTS 154

MDX TEST SENSITIVITY AND SPECIFICITY 155

FIGURE 24 SENSITIVITY AND SPECIFICITY 156

STATUS OF BIOCHIPS DIAGNOSTICS BY INDICATION 157

SUMMARY OF BIOCHIPS DIAGNOSTICS 157

CANCER OVERVIEW 157

TABLE 65 U.S. INCIDENCE AND TREATMENT DECISIONS FOR SELECTED CANCERS, 2009 157

HEMATOLOGICAL CANCERS 158

BLADDER CANCER 158

BREAST CANCER 159

Breast Cancer Screening 159

Prognosis and Pharmacogenetics Tests 160

FIGURE 25 BREAST CANCER TREATMENT DECISION TREE FOR ONCOTYPE DX 161

TABLE 66 ESTIMATED NUMBER OF ANNUAL BREAST CANCER TREATMENT DECISIONS IN THE U.
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SOURCE S OF COMPETITIVE ADVANTAGE IN DNA MICROARRAYS 265
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