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Reportlinker Adds Enzymes in Drug Manufacturing
Date:5/30/2011

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Specialty Enzymes and Biotechnologies (Chino, CA) 119

ZyGEM Corporation (Hamilton, New Zealand) 119

Appendix 120

Scope 120

Methodology 120

Primary research 120

Secondary research 120

Glossary/Abbreviations 121

References 122

Other sources 127

Table of figures

Figure 1: Illustration of structural isomerism 28

Figure 2: Illustration of cis-trans isomerism 29

Figure 3: Illustration of enantiomerism 29

Figure 4: Illustration of diastereoisomerism 31

Figure 5: Main principles of green chemistry 49

Figure 6: Green chemistry drivers and barriers 56

Figure 7: Synthetic biocatalytic route to vitamin C 58

Figure 8: BASF process for producing chirally pure amines 75

Figure 9: Enzymatic resolution using an esterase en route to aliskiren 85

Figure 10: Enzymatic resolution of a racemic alcohol using a lipase 87

Figure 11: Enzymatic steps in the production of zanamavir 91

Figure 12: Challenges and opportunities for extremophiles 105

Table of tables

Table 1: Top 20 pharmaceutical products in the market by sales ($bn), 2009 21

Table 2: Chemical sales by segment, 2007–2012 38

Table 3: White biotech industry growth, 2007–2012 38

Table 4: US biobased chemicals penetration of global market (%), 2010–2025 39

Table 5: Enzymes used in drug manufacturing 73

Table 6: Enzymes often used in resolution processes 74

Table 7: Commercial drugs using biotransformation processes 95

Table 8: Categories of extremophiles 98

Table 9: Examples of extremozymes 104

Table 10: Revenues of leading enzyme companies 114

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