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Reportlinker Adds Enzymes in Drug Manufacturing
Date:5/30/2011

9

Introduction 70

Implementing biocatalysis in drug manufacturing 70

Using enzymatic resolution 73

Enzymes with a track record in the chemical pharmaceutical industry 74

Lipases 75

Oxidoreductases 76

Nitrilases 78

Epoxide hydrolases 78

Hydroxynitrile lyases 78

Aldolases, glycosidases, and glycosyltransferases 79

Amidases 80

The synthesis of chiral amines 80

A comparison of chemical and biocatalysis routes 81

Chapter 6 Case histories of biocatalysis 82

Summary 82

Introduction 83

Specific case studies 83

Pregabalin 83

Aliskiren 84

Posaconazole 85

Ribavirin 86

Beta-lactam antibiotics 87

Biocatalysis in GW's antiviral program 88

Lamivudine 88

Zanamavir 89

Indinavir 91

Aprepitant 92

Paroxetine 92

Levetiracetam 92

Examples of whole-cell biotransformations in drug manufacturing 92

Chapter 7 Industrial enzymes from extremophiles 96

Summary 96

Extremophiles – a largely unexplored resource for industry 97

Case history of a potential industrial enzyme 100

Examples of extremozymes for the pharmaceutical industry 100

The future of extremophile research and its applications 104

Chapter 8 The way forward 106

Summary 106

Introduction 107

Reducing waste 108

A whole-industry approach 108

Making more enzyme tools available 109

Enzymes for pharma – a growing market? 110

Chapter 9 Enzyme companies and their products 112

Summary 112

Introduction 113

Aquapharm Biodiscovery (Oban, UK) 114

ArcticZymes AS (Tromso, Norway) 115

Codexis (Redwood City, CA) 115

DSM Pharmaceutical Products (Parsippany, NJ) 116

Dyadic International Inc (Jupiter, FA) 117

Genecor (Copenhagen, Denmark) 117

Novozymes (Bagsvaerd, Denmark) 118'/>"/>

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