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Reportlinker Adds Enzymes in Drug Manufacturing
Date:5/30/2011

enzyme toolkit 23

Genome and metagenome databases 23

Enzyme engineering and directed evolution 24

Host expression technology 24

Pathway engineering 25

Synthetic biology 25

Regulatory changes favoring biocatalysis 25

Introduction to stereochemistry 26

Structural isomerism 27

Stereoisomerism 28

Cis-trans isomerism 28

Enantiomerism 29

Diastereoisomerism 30

Important functional groups in medicinal chemistry/drug manufacturing 32

The history of the use of enzymes in drug manufacturing 33

Chapter 2 Industrial Biotechnology 34

Summary 34

Introduction 34

Defining industrial biotechnology 35

Enzymes 36

A growing market 37

Government initiatives 38

The US and IB 39

Europe and IB 40

IB – the future 43

Norway – from blue to white biotech 44

Focus on Russia 45

Chapter 3 Green chemistry in drug manufacturing 47

Summary 47

Introduction 47

The growth of green chemistry 48

Enzymes and the rules of green chemistry 49

Green chemistry and big pharma 50

Green chemistry and catalysts 51

Green chemistry infrastructure 53

CoEBio3 53

The Green Chemistry Centre for Industry 55

Drivers and barriers to widespread adoption of green chemistry 55

Patent protection 56

Environmental regulation 57

Education 57

Presidential Green Challenge 57

Green chemistry and vitamin C synthesis 58

Chapter 4 Enzymes and the enzyme industry 60

Summary 60

Introduction 60

The enzyme tool kit 62

Metagenomics 64

Sequence-based discovery 65

Improving on nature's enzymes for industry 65

Rational enzyme design 66

Directed evolution 66

Case study – Lipitor 67

Chapter 5 Overview of the use of enzymes in drug manufacturing 69

Summary 6
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