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Reportlinker Adds Enzymes in Drug Manufacturing
Date:5/30/2011

ials and other inputs by improving efficiency and allowing reactions to take place under milder conditions. Biocatalytic steps often offer a powerful solution to the problem of controlling stereochemistry.

Both green chemistry and industrial biotechnology are important emerging trends worldwide. Enzymes are central to both disciplines so developments are likely to increase the focus on biocatalysis and encourage its wider implementation within industry.

There are many potential sources of innovative enzymes that could meet the needs of pharma. These include organisms from extreme environments and genomic databases. New and old enzymes can be optimized for their properties using technologies such as directed evolution.

Key reasons to purchase this research

- What benefits do enzymes offer compared with conventional chemical synthesis?

- How can an enzymatic steps be integrated into an existing manufacturing process and what are the challenges in so doing?

- Why are enzymes such a key focus in both green chemistry and industrial biotechnology?

- How can a natural enzyme be modified so that its properties are compatible with process conditions typically found in the pharmaceutical industry?

- What sectors of industry currently make the best use of enzymes in their processes and can pharma follow suit?

Table of Contents

About the author 2

Disclaimer 2

Executive summary 11

Introduction 11

Industrial biotechnology 11

Green chemistry in drug manufacturing 12

Enzymes and the enzyme industry 13

Overview of the use of enzymes in drug manufacturing 13

Case histories of biocatalysis 14

Industrial enzymes from extremophiles 15

The way forward 16

Enzyme companies and their products 17

Chapter 1 Introduction 18

Summary 18

Introduction 18

Technical advantages of biocatalysis 21

Expanding the
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