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Reportlinker Adds Biomarkers - technologies, markets and companies

arkers in drug safety studies 96

Genomic technologies for toxicology biomarkers 97

Proteomic technologies for toxicology biomarkers 97

Metabonomic technologies for toxicology biomarkers 98

Integration of genomic and metabonomic data to develop toxicity biomarkers 98

Toxicology studies based on biomarkers 98

Biomarkers of hepatotoxicity 99

Biomarkers of nephrotoxicity 100

Cardiotoxicity 102

Neurotoxicity 102

Applications of biomarkers for drug development 103

Application of metabonomics/metabolomics for drug development 103

Role of pharmacokinetic/pharmacodynamic biomarkers in drug development 103

Molecular imaging as a biomarker in drug development 104

Molecular imaging in preclinical studies 104

Molecular imaging in clinical trials 105

Prospects of molecular imaging in drug discovery and development 106

Biomarkers in clinical trials 106

NIH recommendations on the use of biomarkers in clinical trials 107

Advantages of biomarkers for drug development 108

Limitations and problems with use of biomarkers in clinical trials 109

Application of biomarkers by the pharmaceutical companies 109

Use of biomarkers in relation to stage of drug discovery and development 110

Drug development in cardiovascular disorders 111

Drug development in neurological disorders 111

Future prospects of biomarker-based drug development 112

The Biomarker Alliance 112

Molecular Libraries and Imaging Roadmap of NIH 112

Biomarkers Consortium 113

Pharmacogenomic biomarker information in drug labels 114

5. Role of Biomarkers in Healthcare 115

Introduction 115

Biomarkers of inflammation 115

ESR and CRP as biomarkers of inflammation 116

Biomarkers of oxidative stress 116

1,4-dihydroxynonane-mercapturic acid 116

Oxidative DNA damage 117

Proteins as bi

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