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Reportlinker Adds Biomarkers - technologies, markets and companies
Date:9/7/2010

biomarkers 79

Role of bioinformatics in detection of cancer biomarkers 79

Biomarker databases 80

Gene networks as biomarkers 80

3. Biomarkers and Molecular Diagnostics 81

Introduction 81

Molecular diagnostic technologies 81

Polymerase chain reaction 81

Amplification 81

Target selection 82

Detection of amplified DNA 82

Limitations of PCR 82

Real-time PCR systems 83

Limitations of real-time PCR 83

Future applications of real-time Q-PCR 84

Combined PCR-ELISA 84

Non-PCR methods 84

Linked Linear Amplification 85

Transcription mediated amplification 85

Rapid analysis of gene expression 85

WAVE nucleic acid fragment analysis system 85

DNA probes with conjugated minor groove binder 86

Rolling circle amplification technology 86

Gene-based diagnostics through RCAT 87

RCAT-immunodiagnostics 87

RCAT-biochips 88

RCAT-pharmacogenomics 88

Circle-to-circle amplification 88

Biochips and microarrays 88

Applications of biochips/microarrays 89

Role of biochip/microarrays in discovery of biomarkers 89

Biomarkers and high throughput molecular screening 90

Detection and expression profiling of miRNA 90

Real-time PCR for expression profiling of miRNAs 91

Real-time PCR for expression profiling of miRNAs 91

Use of LNA to explore miRNA 91

Microarrays for analysis of miRNA gene expression 91

4. Biomarkers for Drug Discovery & Development 93

Introduction 93

Biomarker technologies for drug discovery 94

Proteomics-based biomarkers for drug discovery 94

Chemoproteomics 94

Activity-based chemical proteomics 94

Transcriptomics for drug discovery 95

Metabolomics for drug discovery 95

Biomarkers and drug safety 96

Biomarkers of adverse drug reactions 96

Applications of biom
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