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Reportlinker Adds Biomarkers - technologies, markets and companies
Date:9/7/2010

olymorphisms 29

Haplotyping 29

Cell biomarkers of disease 30

Stem cell biomarkers 30

Association of stem cell biomarkers with disease 30

Cancer stem cell biomarkers 30

Endoglin as a functional biomarker of stem cells 31

p75NTR as a biomarker to isolate adipose tissue-derived stem cells 31

Protein expression profile as biomarker of stem cells 31

STEMPRO? EZChek? for analysis of biomarkers of hESCs 32

SSEA-4 as biomarker of MSCs 32

Gaseous mediators as biomarkers of disease 32

Autoantibodies as biomarkers of autoimmune diseases 32

Comparison of various types of biomarkers 33

Biomarkers and systems biology 33

Systems biology approach to biomarker identification 35

Relation of biomarkers to other technologies and healthcare 35

Biomarkers and translational medicine 36

Limitations of use of biomarkers in healthcare 36

2. Technologies for Discovery of Biomarkers 39

Introduction 39

The ideal biomarker 39

Genomic technologies 39

Gene expression 39

Whole genome expression array 40

Gene expression profiling on whole blood samples 41

Profiling gene expression patterns of white blood cells 41

Tissue microarrays for study of biomarkers 41

Epigenomic technologies 42

Discovery of methylation biomarkers 42

Proteomic technologies 43

2D GE 44

Biomarker Amplification Filter 45

CellCarta® proteomics platform 45

Isotope-coded affinity tags 46

Liquid chromatography-MS/MS 46

Lucid Proteomics System 46

Magnetics beads for protein biomarker discovery 47

MASStermind™ 47

Mass spectrometry 47

2D PAGE and mass spectrometry 48

Imaging mass spectrometry 48

MALDI mass spectrometry for biomarker discovery 49

Quantitative tandem MS 50

Single-molecule mass spectrometry using a nanopore 50
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