Navigation Links
Repeat negative CT scan for lung cancer does not encourage ex-smokers to resume the habit
Date:12/2/2009

PHILADELPHIA Assurance of a cancer-free status did not prompt people participating in a long-term computerized tomography (CT) lung-cancer screening program to pick up their cigarettes again, researchers wrote in a study published in Cancer Epidemiology, Biomarkers & Prevention, a journal of the American Association for Cancer Research. The December issue contains a special focus on tobacco.

These findings should negate widespread concern in the lung screening community that reassurance provided by screening, and particularly by a negative screening result, might reduce the motivation to quit smoking among current smokers or lead to resumption of smoking among former smokers, according to the researchers.

"For some reason, people have thought that those who do well in lung cancer screening will feel reassured enough to begin smoking again, but there is no evidence of that in our study," said the senior investigator David M. Burns, M.D., professor emeritus at the University of California, San Diego. "This evidence should provide some comfort that CT scanning does not result in a deleterious effect on cessation."

Lung cancer death is the largest cause of cancer death in the United States, and late stage of disease at diagnosis results in five-year survival rates of only 13 percent, according to the researchers. Therefore, screening for lung cancer is "an attractive target for early detection," they wrote. But evidence on cessation activity from studies of screened populations is scarce, and follow-up has been limited to three years.

The study is part of the Early Lung Cancer Action Program (ELCAP), in which 2,078 participants received annual screenings and periodic smoking-behavior surveys over a follow-up period as long as 12 years. In this substudy, abstinence was examined among 730 smokers, 1,227 former smokers who quit for one year or more at enrollment in the study and 155 smokers who quit during the study's follow-up.

The reassurance provided by lung cancer screening was assessed by comparing smoking behaviors of those with negative scans to those with positive scans, which further testing showed was not malignant. The goal of the study was to define whether consistently negative screening results were associated with less cessation and more relapse over a six-year interval in participants undergoing annual CT screening for lung cancer.

Researchers found that participants who consistently received a negative CT scan had a 28 percent lower likelihood of abstinence from one follow-up to another, compared to those who had a positive result. But over a six-year period, that difference disappeared. There was no significant difference in likelihood of relapse between those with positive and negative scans among any of these groups: former smokers, recent quitters or current smokers who quit during the study.

The 30 percent smoking abstinence rate from this group was also higher than the 23 percent rate reported from a match sample of the U.S population, Burns said.

"This is the first examination of smoking cessation outcomes in a population of individuals being screened for lung cancer with follow-up that is longer than three years, and it shows us that reassurance provided by a negative scan may not be a factor determining long-term abstinence," he said.


'/>"/>

Contact: Jeremy Moore
jeremy.moore@aacr.org
267-646-0557
American Association for Cancer Research
Source:Eurekalert

Related biology news :

1. Repeat C-section before 39 weeks raises risk of neonatal illness
2. Biologists discover link between CGG repeats in DNA and neurological disorders
3. Uncharged organic molecule can bind negatively charged ions
4. Arable land can have a negative impact on air quality
5. Fat intake negatively influences the sleep pattern in healthy adults
6. Caloric intake negatively influences healthy adults sleep patterns
7. New Study Reveals the Emotional Impact and Effectiveness of Negative Campaigning
8. Caltech-led researchers find negative cues from appearance alone matter for real elections
9. Ireland Cancer Center researcher finds most triple-negative breast cancers express muc-1 target
10. MIT: Why we have difficulty recognizing faces in photo negatives
11. Study finds multidrug-resistant gram-negative bacteria high in long-term care
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/16/2016)... , May 16, 2016   EyeLock LLC , ... announced the opening of an IoT Center of Excellence ... and expand the development of embedded iris biometric applications. ... level of convenience and security with unmatched biometric accuracy, ... identity aside from DNA. EyeLock,s platform uses video technology ...
(Date:5/9/2016)... 9, 2016 Elevay is currently ... expanding freedom for high net worth professionals seeking travel ... globally connected world, there is still no substitute for ... duplicate sealing your deal with a firm handshake. This ... taking advantage of citizenship via investment programs like those ...
(Date:4/28/2016)... India , April 28, 2016 ... Infosys (NYSE: INFY ), and Samsung SDS, a ... that will provide end customers with a more secure, ... services.      (Logo: http://photos.prnewswire.com/prnh/20130122/589162 ) , ... services, but it also plays a fundamental part in enabling ...
Breaking Biology News(10 mins):
(Date:6/27/2016)... ... ... Parallel 6 , the leading software as a service (SaaS) provider ... Patient Encounter CONSULT module which enables both audio and video telemedicine communication between the ... the CONSULT module, patients and physicians can schedule a face to face virtual patient ...
(Date:6/27/2016)... , June 27, 2016   Ginkgo Bioworks ... to industrial engineering, was today awarded as one ... selection of the world,s most innovative companies. Ginkgo ... scale for the real world in the nutrition, ... engineers work directly with customers including Fortune 500 ...
(Date:6/24/2016)... ... June 24, 2016 , ... Researchers at the Universita ... miRNAs in people with peritoneal or pleural mesothelioma. Their findings are the subject of ... now. , Diagnostic biomarkers are signposts in the blood, lung fluid or tissue ...
(Date:6/23/2016)... , June 23, 2016 /PRNewswire/ - FACIT ... Ontario biotechnology company, Propellon Therapeutics ... development and commercialization of a portfolio of first-in-class ... Epigenetic targets such as WDR5 represent an exciting ... significantly in precision medicine for cancer patients. Substantial ...
Breaking Biology Technology: