Navigation Links
Rensselaer leads effort to replace 1 of the most widely used drugs in American hospitals
Date:9/17/2009

Troy, N.Y. In early 2008, there was a frightening failure in drug safety processes. In just a few weeks, more than 100 Americans had died after being administered contaminated doses of the common blood thinner heparin. The contaminant, present in heparin manufactured in China and discovered with the help of scientists from Rensselaer Polytechnic Institute, was so structurally similar to pure heparin that is was undetectable to all but the most sophisticated detection techniques. As a result, many people became seriously ill or died around the world and the several hundred thousand patients that receive the drug every day in the U.S. were put at risk.

The health crisis pointed to very large problems with the safety processes surrounding heparin, which is one of the most commonly administered drugs in American hospitals today. Most notably, it called worldwide attention to the risks posed by a product made nearly entirely of material from the guts of foreign livestock in less stringently regulated overseas factories. With a $4.6 million grant from the National Institutes of Health (under the Bioengineering Research Partnership program), research led by Rensselaer Polytechnic Institute will make its important final steps toward the development of a safer, synthetic alternative to current heparin. The researchers believe that kilogram quantities of the new drug could be developed in under five years.

"Our goal is to create a bioengineered heparin that is chemically and biologically equivalent to pharmaceutical heparin currently prepared from pig intestines," said Jonathan Dordick , one of the lead researchers for the study, who is the Howard P. Isermann Professor of Chemical and Biological Engineering and Director of the Center for Biotechnology and Interdisciplinary Studies (CBIS). "Our process will improve the safety and uniformity of heparin and prevent future contamination or adulteration of the important drug."

Dordick will be joined
'/>"/>

Contact: Gabrielle DeMarco
demarg@rpi.edu
518-276-6542
Rensselaer Polytechnic Institute
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Deadly dose: Rensselaer heparin expert helps uncover source of lethal contamination
2. Trustee makes donation to start new solar energy research center at Rensselaer
3. Rensselaer receives more than $2 million from New York State to fund stem cell research
4. Meth exposure in young adults leads to long-term behavioral consequences
5. Seattle Childrens Hospital leads $23.7 million NIH grant to study gene repair
6. UD leads $5.3-million research project on rice epigenetics
7. UD leads $5.3-million research project on rice epigenetics
8. Nature leads the way for the next generation of paints, cosmetics and holograms
9. Massive microRNA scan uncovers leads to treating muscle degeneration
10. Scripps Research discovery leads to broad potential applications in CovX-Pfizer deal
11. The construction of heart modelling leads path to new therapies
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:9/18/2014)... A novel robotic system that can operate inside ... tested as part of a biomedical research partnership program ... aim of determining if the robot, in conjunction with ... more accurate, less costly, and less discomforting for the ... deliver prostate cancer therapies with greater precision. , Developed ...
(Date:9/18/2014)... starts a "frequent flyers" program, fruit flies surely would ... has hosted increasing numbers of fruit fly research studies. ... in April, and another is scheduled launch to the ... launch in December. , Fruit flies are biomedical research ... space. Model organisms can reveal the basis for health ...
(Date:9/18/2014)... foliage season that prompts millions of Americans to undertake jaunts ... possibly last a little longer within a century, according to ... in some areas of the United States as summer temperatures ... the journal Global Ecology and Biogeography . For instance, ... the state tree of New Hampshire could change color ...
Breaking Biology News(10 mins):Trial begins for MRI-compatible robot designed to improve accuracy of prostate biopsies 2Trial begins for MRI-compatible robot designed to improve accuracy of prostate biopsies 3Trial begins for MRI-compatible robot designed to improve accuracy of prostate biopsies 4Trial begins for MRI-compatible robot designed to improve accuracy of prostate biopsies 5Buzzing with activity: Fruit flies orbit Earth for science 2Buzzing with activity: Fruit flies orbit Earth for science 3Buzzing with activity: Fruit flies orbit Earth for science 4Fall foliage season may be later, but longer on warmer Earth 2Fall foliage season may be later, but longer on warmer Earth 3Fall foliage season may be later, but longer on warmer Earth 4
... at the University of South Florida (USF) College of Public ... rodent model that the earliest form of malaria parasites can ... recover, following treatment with the antimalarial drug artesunate. The ... PLoS ONE , suggests that this early-stage dormancy phenomenon ...
... 25, 2011 DST Health Solutions ... Community Health Plan (CCHP) has implemented its PowerMHC® ... Suite to help meet new market requirements and enhance ... implement a nurse assist line service for CCHP, which ...
... is getting even harder to find in the Sierra Nevada, ... the U.S. Forest Service and Oregon State University. A new ... have dropped 60 percent since the 1980sa decrease that may ... which they live, researchers say. Their findings appeared in the ...
Cached Biology News:Dormant malaria parsites in red blood cells may contribute to treatment failure 2DST Health Solutions' Integrated Care Management Suite Improves Care Quality, Population Management of 31,000+ Member Health Plan 2DST Health Solutions' Integrated Care Management Suite Improves Care Quality, Population Management of 31,000+ Member Health Plan 3Fewer marten detections in California forest linked to decline in habitat 2
(Date:9/19/2014)... 19, 2014 , The first ... for Paediatric Endocrinology (ESPE) Meeting  Investment supports ... research in the field of growth  , ... Germany , today announced the first recipients ... The awards were announced during a Satellite Symposium organized ...
(Date:9/18/2014)... September 18, 2014 HealthTronics, ... and interventional radiology products and services, announced that ... cryotherapy and cryoablation) versus external beam radiotherapy (EBRT) ... the American Urological Association (MAAUA) Annual Meeting in ... Relative Effectiveness of Cryosurgery and External Beam Radiation ...
(Date:9/18/2014)... 2014 A novel robotic system that ... is currently being tested as part of a biomedical ... Boston with the aim of determining if the robot, ... cancer biopsies faster, more accurate, less costly, and less ... the potential to deliver prostate cancer therapies with greater ...
(Date:9/18/2014)... Texas (PRWEB) September 18, 2014 ... Chancellor John Sharp, Texas A&M Health Science Center ... U.S. Department of Health and Human Services (HHS), ... dedicated a national pandemic influenza vaccine manufacturing facility ... as an anchor for the Texas A&M Biocorridor ...
Breaking Biology Technology:EMD Serono Awards Grant for Growth Innovation (GGI) for the First Time 2EMD Serono Awards Grant for Growth Innovation (GGI) for the First Time 3HealthTronics Announces Data Comparing Cryotherapy Versus Radiation for Treating Prostate Cancer Poster Presented at the American Urological Association Regional Meeting 2Worcester Polytechnic Institute Participates in Clinical Trial for MRI-Compatible Robot Designed to Improve Accuracy of Prostate Cancer Biopsies 2Worcester Polytechnic Institute Participates in Clinical Trial for MRI-Compatible Robot Designed to Improve Accuracy of Prostate Cancer Biopsies 3Worcester Polytechnic Institute Participates in Clinical Trial for MRI-Compatible Robot Designed to Improve Accuracy of Prostate Cancer Biopsies 4Worcester Polytechnic Institute Participates in Clinical Trial for MRI-Compatible Robot Designed to Improve Accuracy of Prostate Cancer Biopsies 5Worcester Polytechnic Institute Participates in Clinical Trial for MRI-Compatible Robot Designed to Improve Accuracy of Prostate Cancer Biopsies 6Texas A&M Dedicates National Pandemic Influenza Vaccine Manufacturing Facility, on Track for 2016 Start-Up Phase 2Texas A&M Dedicates National Pandemic Influenza Vaccine Manufacturing Facility, on Track for 2016 Start-Up Phase 3Texas A&M Dedicates National Pandemic Influenza Vaccine Manufacturing Facility, on Track for 2016 Start-Up Phase 4
... -- Cingular Wireless will invest more than $300 ... Wisconsin -- including turning on-air 110 new cell sites, ... will spend $6.2 billion to enhance and expand its ... year, Cingular put into service 22 cell ...
... Attorney Joe Hildebrandt has been a part of ... some close at home and others in the financial ... the years, Hildebrandt told a legislative committee last week, ... state" that neither wants nor welcomes investors. , ,Lately, ...
... Wis. - Milton Silva-Craig has joined the board ... reported on Monday. , ,Neurognostics, which spun out of ... resonance imaging (fMRI) products and services , ,Silva-Craig is ... which he joined in March, 2001. Emageon ...
Cached Biology Technology:State's investment in early-stage businesses is changing perceptions 2State's investment in early-stage businesses is changing perceptions 3
... your protein is in solution or in a ... mass spectrometry. Proteins will be digested to produce ... of the peptides are determined by MALDI-TOF, and ... peaks (peptides) from MALDI-TOF will be determined by ...
OmniSlide Heated Wash Module. 2 independent chambers with precise temperature control from ambient of 5C to 70C. Each chamber holds 1 slide rack (20 slides). Includes 2 x Wash Sleeves, 1 x Slide R...
For cleavage of 6xHis tags from proteins containing a Factor Xa Protease recognition site Efficient 6xHis tag cleavage (greater than 90%), ...
Request Info...
Biology Products: