Navigation Links
Rensselaer leads effort to replace 1 of the most widely used drugs in American hospitals
Date:9/17/2009

Troy, N.Y. In early 2008, there was a frightening failure in drug safety processes. In just a few weeks, more than 100 Americans had died after being administered contaminated doses of the common blood thinner heparin. The contaminant, present in heparin manufactured in China and discovered with the help of scientists from Rensselaer Polytechnic Institute, was so structurally similar to pure heparin that is was undetectable to all but the most sophisticated detection techniques. As a result, many people became seriously ill or died around the world and the several hundred thousand patients that receive the drug every day in the U.S. were put at risk.

The health crisis pointed to very large problems with the safety processes surrounding heparin, which is one of the most commonly administered drugs in American hospitals today. Most notably, it called worldwide attention to the risks posed by a product made nearly entirely of material from the guts of foreign livestock in less stringently regulated overseas factories. With a $4.6 million grant from the National Institutes of Health (under the Bioengineering Research Partnership program), research led by Rensselaer Polytechnic Institute will make its important final steps toward the development of a safer, synthetic alternative to current heparin. The researchers believe that kilogram quantities of the new drug could be developed in under five years.

"Our goal is to create a bioengineered heparin that is chemically and biologically equivalent to pharmaceutical heparin currently prepared from pig intestines," said Jonathan Dordick , one of the lead researchers for the study, who is the Howard P. Isermann Professor of Chemical and Biological Engineering and Director of the Center for Biotechnology and Interdisciplinary Studies (CBIS). "Our process will improve the safety and uniformity of heparin and prevent future contamination or adulteration of the important drug."

Dordick will be joined
'/>"/>

Contact: Gabrielle DeMarco
demarg@rpi.edu
518-276-6542
Rensselaer Polytechnic Institute
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Deadly dose: Rensselaer heparin expert helps uncover source of lethal contamination
2. Trustee makes donation to start new solar energy research center at Rensselaer
3. Rensselaer receives more than $2 million from New York State to fund stem cell research
4. Meth exposure in young adults leads to long-term behavioral consequences
5. Seattle Childrens Hospital leads $23.7 million NIH grant to study gene repair
6. UD leads $5.3-million research project on rice epigenetics
7. UD leads $5.3-million research project on rice epigenetics
8. Nature leads the way for the next generation of paints, cosmetics and holograms
9. Massive microRNA scan uncovers leads to treating muscle degeneration
10. Scripps Research discovery leads to broad potential applications in CovX-Pfizer deal
11. The construction of heart modelling leads path to new therapies
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:4/22/2014)... Consortium Ltd.,s nanotechnology expert will present a poster ... at the 7th International Nanotoxicology Congress to ... , Dr. Monita Sharma will outline a strategy consistent ... of Sciences, " Toxicity Testing in the 21st Century: ... of non-animal methods involving human cells and cell lines ...
(Date:4/22/2014)... presented Beaumont Health System with prestigious, competitive research ... athletic and nonathletic injuries. , The American ... grant to fund stem cell-based research that could ... ruptured knee anterior cruciate ligament, or ACL. According ... cruciate ligament injury is the over-stretching or tearing ...
(Date:4/22/2014)... at the University of Kentucky has discovered new methods ... , The research, led by Peixuan Guo, professor ... the UK College of Pharmacy and Markey Cancer Center, ... Boiling-Resistant Anionic Polymer Material To Build Robust Structures with ... and Daniel L. Jasinski. , The article, which will ...
Breaking Biology News(10 mins):Beaumont awarded grants to study sports-related injury treatment, improve recovery 2RNA shows potential as boiling-resistant anionic polymer material for nanoarchitectures 2
... has discovered the first identified droplets of spider blood in ... , Two droplets of blood, technically known as haemolymph, have ... - Filistatidae - a family commonly found in South America ... examples of spider blood ever found in an amber fossil. ...
... painkiller prompts brain to release endorphins, bringing real relief ... medicine will relieve pain is enough to prompt the ... painful sensations, a new University of Michigan study finds. ... the brain's own pain-fighting chemicals, called endorphins, play a ...
... completed 60 days of voluntary bedrest in order to ... body. The research team in Toulouse, France, is now ... continue and enhance the research. , At the beginning ... of the WISE study (Women International Simulation Experiment), were ...
Cached Biology News:Spider blood found in 20 million year old fossil 2Thinking the pain away? Study shows the brain's painkillers may cause 'placebo effect' 2Thinking the pain away? Study shows the brain's painkillers may cause 'placebo effect' 3Thinking the pain away? Study shows the brain's painkillers may cause 'placebo effect' 4Female volunteers prepare for a second 'bedrest' 2
(Date:1/14/2014)... As pet owners drew up their lists of New Year,s resolutions ... care of my furry companion." Nowadays there are pet salons, dog ... to take the little canine or feline darlings along wherever mommy ... some pricey toys at the pet store. But anyone who has ...
(Date:1/14/2014)... BETHESDA, Md. , Jan. 14, 2014 ... two institutes from the National Institutes of Health (NIH) ... safer, more effective treatments to patients on a faster ... Advancing Translational Sciences (NCATS) and the National Eye Institute ...
(Date:1/14/2014)... 2014  RXi Pharmaceuticals Corporation (OTCQX: RXII), a biotechnology ... therapies addressing major unmet medical needs using RNA-targeted ... of Allowance from the United States Patent and ... (sd-rxRNA®), for the treatment of fibrosis. The patent ...
(Date:1/14/2014)... 13, 2014 Bob Hainsey, a semiconductor ... 20 years in the industry, has joined SPIE, ... will serve as the society’s Science and Technology Strategist. ... SPIE as our Technology Strategist, further strengthening the technical ...
Breaking Biology Technology:New Year's Resolution: Give Pets the Gift of Top-Notch Health Care 2Organovo Announces Collaboration with National Institutes of Health 2Organovo Announces Collaboration with National Institutes of Health 3RXi Pharmaceuticals Receives US Notice of Allowance for a Key Patent Relating to its Self-Delivering Technology with sd-rxRNAs targeting CTGF, including RXI-109, for the Treatment of Fibrotic Disorders 2RXi Pharmaceuticals Receives US Notice of Allowance for a Key Patent Relating to its Self-Delivering Technology with sd-rxRNAs targeting CTGF, including RXI-109, for the Treatment of Fibrotic Disorders 3Photonics R&D Leader Bob Hainsey Joins SPIE Technical Staff 2
... has launched PATHT HTS, a new platform for high-throughput ... the microarray industry's annual conference, Chips To Hits in ... the performance of PATH protein microarray slides," said Robert ... BioSurfaces. "PATH HTS was designed to meet the ...
... The NeuronFarm, a developer of Web-based applications intended ... immediate availability of its flagship product, 3D-Readers. , ... third through eighth graders in several school studies, ... automated text scoring, engaging simulations and immediate feedback ...
... As more organizations look at what needs to be ... an area that has come under the spotlight is ... corporate governance issues have become issues even within the ... Act (SOX) has become a reason to organize and ...
Cached Biology Technology:NeuronFarm's 3D-Reader ready to ship 2Sarbox necessitating ECM software, but beware of `best practices' 2Sarbox necessitating ECM software, but beware of `best practices' 3
Recombinant Rat Leptin, CF...
delta-like 1 homolog (Drosophila)...
... 71-18 mutS and ES1301 mutS are mismatch ... of these strains prevents repair of the ... high mutation efficiencies and making them helpful ... Altered Sites II Mutagenesis Systems. Both ES1301 ...
Request Info...
Biology Products: