Navigation Links
Rensselaer leads effort to replace 1 of the most widely used drugs in American hospitals
Date:9/17/2009

Troy, N.Y. In early 2008, there was a frightening failure in drug safety processes. In just a few weeks, more than 100 Americans had died after being administered contaminated doses of the common blood thinner heparin. The contaminant, present in heparin manufactured in China and discovered with the help of scientists from Rensselaer Polytechnic Institute, was so structurally similar to pure heparin that is was undetectable to all but the most sophisticated detection techniques. As a result, many people became seriously ill or died around the world and the several hundred thousand patients that receive the drug every day in the U.S. were put at risk.

The health crisis pointed to very large problems with the safety processes surrounding heparin, which is one of the most commonly administered drugs in American hospitals today. Most notably, it called worldwide attention to the risks posed by a product made nearly entirely of material from the guts of foreign livestock in less stringently regulated overseas factories. With a $4.6 million grant from the National Institutes of Health (under the Bioengineering Research Partnership program), research led by Rensselaer Polytechnic Institute will make its important final steps toward the development of a safer, synthetic alternative to current heparin. The researchers believe that kilogram quantities of the new drug could be developed in under five years.

"Our goal is to create a bioengineered heparin that is chemically and biologically equivalent to pharmaceutical heparin currently prepared from pig intestines," said Jonathan Dordick , one of the lead researchers for the study, who is the Howard P. Isermann Professor of Chemical and Biological Engineering and Director of the Center for Biotechnology and Interdisciplinary Studies (CBIS). "Our process will improve the safety and uniformity of heparin and prevent future contamination or adulteration of the important drug."

Dordick will be joined
'/>"/>

Contact: Gabrielle DeMarco
demarg@rpi.edu
518-276-6542
Rensselaer Polytechnic Institute
Source:Eurekalert

Page: 1 2 3

Related biology news :

1. Deadly dose: Rensselaer heparin expert helps uncover source of lethal contamination
2. Trustee makes donation to start new solar energy research center at Rensselaer
3. Rensselaer receives more than $2 million from New York State to fund stem cell research
4. Meth exposure in young adults leads to long-term behavioral consequences
5. Seattle Childrens Hospital leads $23.7 million NIH grant to study gene repair
6. UD leads $5.3-million research project on rice epigenetics
7. UD leads $5.3-million research project on rice epigenetics
8. Nature leads the way for the next generation of paints, cosmetics and holograms
9. Massive microRNA scan uncovers leads to treating muscle degeneration
10. Scripps Research discovery leads to broad potential applications in CovX-Pfizer deal
11. The construction of heart modelling leads path to new therapies
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:5/22/2015)... Inc. (NASDAQ: NXTD ) ("NXT-ID" or the "Company") announces ... pricing and making the Wocket generally available for $229 via ... of Marketing said, "We,ve extended the opportunity to take advantage ... To get your wocket at this special price, submit your ... June 1, you,ll receive a unique code that gives you ...
(Date:5/20/2015)... , May 20, 2015 ... ) has announced the addition of ... Global Iris Recognition Market"  report to ... ,This research service analyses trends in ... government and commercial sectors, globally. Despite ...
(Date:5/19/2015)... , May 19, 2015 ... has announced the addition of the  "Genetic ... offering.  ,     (Logo: http://photos.prnewswire.com/prnh/20130307/600769) , ,A recent ... an in-depth analysis of the current and ... of gene-based tests, their working principles and ...
Breaking Biology News(10 mins):NXT-ID, Inc Announces Retail Price For Wocket Smart Wallet And Extends Discounted Promotional Price Till End Of May 2NXT-ID, Inc Announces Retail Price For Wocket Smart Wallet And Extends Discounted Promotional Price Till End Of May 3Global Iris Recognition Market Report 2015 - 5-Year Opportunity Analysis 2Global Genetic Testing Market Outlook 2018 2
... -- Wild migratory birds may indeed play a role in ... avian influenza H5N1. A study by the U.S. ... the Chinese Academy of Sciences used satellites, outbreak data and ... birds, poultry and the movement of the often-deadly virus. ...
... from climate change in the Southwest will likely eliminate Joshua ... to 90 years, according to a new study led by ... used models of future climate, an analysis of the climatic ... fossil record to project the future distribution of Joshua trees. ...
... release is available in German . , The ... estimation of population sizes. However, the monitoring of population sizes, ... and effective conservation action. Scientists from the Max Planck Institute ... and female parti-colored bats ( Vespertilio murinus ) and found ...
Cached Biology News:New research suggests wild birds may play a role in the spread of bird flu 2Uncertain future for Joshua trees projected with climate change 2Bats keep separate households 2Bats keep separate households 3
(Date:6/1/2015)... IL (PRWEB) June 01, 2015 ... developing and manufacturing of chiral stationary phases (CSPs) ... options for its current and presenting solutions for ... to its portfolio. This valuable addition to its ... and effective advantage that can tackle projects for ...
(Date:6/1/2015)... June 1, 2015  Boston-based Veritas Genetics is ... industry and bring personalized medicine and prevention to ... of their health. Beginning with its first product, ... cancer risk, Veritas Genetics is making its products ... the amount of genetic data which will be ...
(Date:6/1/2015)... 2015 Sistemic Ltd. and RoosterBio ... a commercial collaboration agreement and signed a memorandum ... technologies and work together towards advancing the field ... and Sistemic will collaborate on utilizing microRNA (miRNA)-based ... precise and relevant characterization panels for hMSC products ...
(Date:6/1/2015)... DIEGO , June 1, 2015   Epic ... and develops products and offerings to personalize and advance ... it has expanded the available credit under its existing ... The amended agreement increases the available capacity of the ... extended the maturity by 27 months to April 1, ...
Breaking Biology Technology:Regis Technologies Offers Chiral Chromatography Service 2Regis Technologies Offers Chiral Chromatography Service 3Veritas Genetics To Advance Precision Medicine And Disease Prevention 2Veritas Genetics To Advance Precision Medicine And Disease Prevention 3Sistemic and RoosterBio Inc Announce Broad Collaboration Agreement to Advance miRNA and Mesenchymal Stem/Stromal Cell (MSC) Regenerative Technology 2Sistemic and RoosterBio Inc Announce Broad Collaboration Agreement to Advance miRNA and Mesenchymal Stem/Stromal Cell (MSC) Regenerative Technology 3Sistemic and RoosterBio Inc Announce Broad Collaboration Agreement to Advance miRNA and Mesenchymal Stem/Stromal Cell (MSC) Regenerative Technology 4Epic Sciences Expands Silicon Valley Bank Credit Facility 2Epic Sciences Expands Silicon Valley Bank Credit Facility 3
... Metavante Corp. said it has ... which makes software that handles bank transactions and check ... & Isley Corp, said in October that it ... software company into a wholly owned subsidiary. The move ...
... the home stretch of the year with just December to go. ... are in reality about two weeks left in the year as ... as IPOs go) by the middle of December. New activity won't ... like a promising and valiant biotech IPO market has fizzled out ...
... new CEO will draw investment to its work in gene mapping, ... CEO of medical firms Quantech and Cathra International. , ,I think ... serious funds, and we hope he continues to do the same ... a professor of genetics at the University of Wisconsin-Madison. Hes the ...
Cached Biology Technology:Midwest life-science company Perrigo globalizes under the radar 2Midwest life-science company Perrigo globalizes under the radar 3Midwest life-science company Perrigo globalizes under the radar 4Midwest life-science company Perrigo globalizes under the radar 5OpGen recruits CEO to further gene-mapping business 2
Monoclonal mouse antibody for immunihistology, clone AD12, Isotype IgG 1, purified, specific for rat pyruvatekinase type L, no cross-reactivities with other pyruvate kinase isoenzymes have been obser...
For testing the AQUA technique on your MS instruments....
A robust formulation of Taq Polymerase supplied with a 10X colored reaction buffer which allows Direct Gel-Loading...
... Synonym: Dinitro-5,5'-dithiodibenzoic acid , DTNB , ... 396.36 g/mol , *CAS-No.: 69-78-3 ... a product with a reactive grouping not present ... include a reagent which will react directly with ...
Biology Products: