Navigation Links
Renewal grant supports genetic research into arthritis of the spine
Date:11/9/2012

An international team of scientists searching for genes that determine the susceptibility and severity of arthritis of the spine has been awarded a five-year renewal grant of $4.3 million from the National Institutes of Health.

The team led by John Reveille, M.D., of The University of Texas Health Science Center at Houston (UTHealth) Medical School, has linked 20-plus genes to this arthritic condition known as ankylosing spondylitis and hopes to use this information to enhance diagnosis and treatment.

Reveille, chairman of the Division of Rheumatology and Clinical Immunogenetics at the UTHealth Medical School and chief of rheumatology at Memorial Hermann-Texas Medical Center, said this information could lead to diagnostic tests to identify high-risk individuals and to new treatments that could potentially correct abnormal activities associated with disease-contributing genes.

"We hope to diagnose the disease earlier and more accurately and to improve outcomes," Reveille said.

The team is tracking the progress of people with this form of inflammatory arthritis. It began with a cohort of 400 people in 2006. Today the investigators are following more than 1,200 patients. The team is studying the genetic makeup of patients, as well as the impact of treatments on their condition.

Ankylosing spondylitis, sometimes mistaken for simple back pain and strain, affects 129 out of every 100,000 people in the United States and affects people of all ages and of both genders. Symptoms include curvature of the spine, weight loss, eye inflammation, fatigue and anemia.

While there is no cure, early diagnosis and proper management can minimize pain and reduce the risk of deformity, said Reveille, the Linda and Ronny Finger Foundation Distinguished Chair in Neuroimmunologic Disorders and the George S. Bruce, Jr. Professor in Arthritis and Other Rheumatic Diseases at the UTHealth Medical School.

Ankylosing spondylitis is often treated with non-steroidal anti-inflammatory drugs and exercise, and, in severe cases, anti-tumor necrosis factor (TNF) agents, he said.


'/>"/>
Contact: Robert Cahill
Robert.Cahill@uth.tmc.edu
713-500-3030
University of Texas Health Science Center at Houston
Source:Eurekalert  

Related biology news :

1. Scientist wins $3 million renewal of one of longest-running NIH grants to Scripps Research
2. Baylor University scientist receives major grants for health research on 1991 Gulf War veterans
3. Carnegie Institution for Science receives Grand Challenges Explorations grant
4. BRI receives Grand Challenges Explorations Grant
5. New grant to establish pan-continental bioinformatics research network in Africa
6. Feinstein Institute receives $1 million grant to study impact of World Trade Center attacks on responders
7. FDA Grants Meridian Laboratories Pre-Ind Meeting for Captisol-Enabled Docetaxel in the Treatment of Cancer
8. Emory receives $20 million NSF grant for chemistry center
9. Mount Sinai researchers awarded Provocative Questions grant from National Cancer Institute
10. UNH labs receive 2 NSF grants totalling $1.35m for research instruments
11. Columbia awarded 1 of first Provocative Questions grants from NCI
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Renewal grant supports genetic research into arthritis of the spine
(Date:4/19/2017)... 2017 The global military biometrics ... marked by the presence of several large global players. ... five major players - 3M Cogent, NEC Corporation, M2SYS ... nearly 61% of the global military biometric market in ... global military biometrics market boast global presence, which has ...
(Date:4/11/2017)... PALM BEACH GARDENS, Fla. , April 11, ... biometric identity management and secure authentication solutions, today ... million contract by Intelligence Advanced Research Projects Activity ... technologies for IARPA,s Thor program. "Innovation ... the onset and IARPA,s Thor program will allow ...
(Date:4/5/2017)...  The Allen Institute for Cell Science today announces ... portal and dynamic digital window into the human cell. ... application of deep learning to create predictive models of ... a growing suite of powerful tools. The Allen Cell ... publicly available resources created and shared by the Allen ...
Breaking Biology News(10 mins):
(Date:10/11/2017)... ... 11, 2017 , ... Disappearing forests and increased emissions are the main causes ... each year. Especially those living in larger cities are affected by air pollution related ... the most pollution-affected countries globally - decided to take action. , “I knew I ...
(Date:10/10/2017)... (PRWEB) , ... October 10, 2017 , ... San Diego-based ... of its corporate rebranding initiative announced today. The bold new look is part ... as the company moves into a significant growth period. , It will also expand ...
(Date:10/10/2017)... ... October 10, 2017 , ... Dr. Bob Harman, founder and CEO of ... Club. The event entitled “Stem Cells and Their Regenerative Powers,” was ... Dr. Harman, DVM, MPVM was joined by two human doctors: Peter B. Hanson, M.D., ...
(Date:10/10/2017)... (PRWEB) , ... October 10, 2017 , ... ... innovation and business process optimization firm for the life sciences and healthcare industries, ... conference in San Francisco. , The presentation, “Automating GxP Validation for Agile ...
Breaking Biology Technology: