Navigation Links
Renewal grant supports genetic research into arthritis of the spine
Date:11/9/2012

An international team of scientists searching for genes that determine the susceptibility and severity of arthritis of the spine has been awarded a five-year renewal grant of $4.3 million from the National Institutes of Health.

The team led by John Reveille, M.D., of The University of Texas Health Science Center at Houston (UTHealth) Medical School, has linked 20-plus genes to this arthritic condition known as ankylosing spondylitis and hopes to use this information to enhance diagnosis and treatment.

Reveille, chairman of the Division of Rheumatology and Clinical Immunogenetics at the UTHealth Medical School and chief of rheumatology at Memorial Hermann-Texas Medical Center, said this information could lead to diagnostic tests to identify high-risk individuals and to new treatments that could potentially correct abnormal activities associated with disease-contributing genes.

"We hope to diagnose the disease earlier and more accurately and to improve outcomes," Reveille said.

The team is tracking the progress of people with this form of inflammatory arthritis. It began with a cohort of 400 people in 2006. Today the investigators are following more than 1,200 patients. The team is studying the genetic makeup of patients, as well as the impact of treatments on their condition.

Ankylosing spondylitis, sometimes mistaken for simple back pain and strain, affects 129 out of every 100,000 people in the United States and affects people of all ages and of both genders. Symptoms include curvature of the spine, weight loss, eye inflammation, fatigue and anemia.

While there is no cure, early diagnosis and proper management can minimize pain and reduce the risk of deformity, said Reveille, the Linda and Ronny Finger Foundation Distinguished Chair in Neuroimmunologic Disorders and the George S. Bruce, Jr. Professor in Arthritis and Other Rheumatic Diseases at the UTHealth Medical School.

Ankylosing spondylitis is often treated with non-steroidal anti-inflammatory drugs and exercise, and, in severe cases, anti-tumor necrosis factor (TNF) agents, he said.


'/>"/>
Contact: Robert Cahill
Robert.Cahill@uth.tmc.edu
713-500-3030
University of Texas Health Science Center at Houston
Source:Eurekalert  

Related biology news :

1. Scientist wins $3 million renewal of one of longest-running NIH grants to Scripps Research
2. Baylor University scientist receives major grants for health research on 1991 Gulf War veterans
3. Carnegie Institution for Science receives Grand Challenges Explorations grant
4. BRI receives Grand Challenges Explorations Grant
5. New grant to establish pan-continental bioinformatics research network in Africa
6. Feinstein Institute receives $1 million grant to study impact of World Trade Center attacks on responders
7. FDA Grants Meridian Laboratories Pre-Ind Meeting for Captisol-Enabled Docetaxel in the Treatment of Cancer
8. Emory receives $20 million NSF grant for chemistry center
9. Mount Sinai researchers awarded Provocative Questions grant from National Cancer Institute
10. UNH labs receive 2 NSF grants totalling $1.35m for research instruments
11. Columbia awarded 1 of first Provocative Questions grants from NCI
Post Your Comments:
*Name:
*Comment:
*Email:
Related Image:
Renewal grant supports genetic research into arthritis of the spine
(Date:6/2/2016)... 2, 2016   The Weather Company , an IBM ... an industry-first capability in which consumers will be able to ... ask questions via voice or text and receive relevant information ... Marketers have long sought an advertising solution that ... be personal, relevant and valuable; and can scale across millions ...
(Date:5/20/2016)... May 20, 2016  VoiceIt is excited to ... VoicePass. By working together, VoiceIt and ... VoiceIt and VoicePass take slightly different approaches to ... both security and usability. ... this new partnership. "This marketing and ...
(Date:5/3/2016)... VILNIUS, Lithuania , May 3, 2016 /PRNewswire/ ... today released the MegaMatcher Automated Biometric Identification ... deployment of large-scale multi-biometric projects. MegaMatcher ABIS can ... and accuracy using any combination of fingerprint, face ... of MegaMatcher SDK and MegaMatcher ...
Breaking Biology News(10 mins):
(Date:6/23/2016)... TORONTO , June 23, 2016 /PRNewswire/ - ... Ontario biotechnology company, Propellon ... the development and commercialization of a portfolio of ... cancers. Epigenetic targets such as WDR5 represent an ... contribute significantly in precision medicine for cancer patients. ...
(Date:6/23/2016)...  The Biodesign Challenge (BDC), a university competition that ... living systems and biotechnology, announced its winning teams at ... New York City . The teams, ... at MoMA,s Celeste Bartos Theater during the daylong summit. ... curator of architecture and design, and Suzanne Lee ...
(Date:6/23/2016)... 23, 2016 Apellis Pharmaceuticals, Inc. today ... trials of its complement C3 inhibitor, APL-2. The ... ascending dose studies designed to assess the safety, ... injection in healthy adult volunteers. Forty ... a single dose (ranging from 45 to 1,440mg) ...
(Date:6/23/2016)... Pleasant Prairie, WI (PRWEB) , ... June 23, ... ... sciences consultancy focused on quality, regulatory and technical consulting, provides a free ... webinar is presented on July 13, 2016 at 12pm CT at no charge. ...
Breaking Biology Technology: