Navigation Links
'Remote control' for cholesterol regulation discovered in brain
Date:6/6/2010

CINCINNATICirculation of cholesterol is regulated in the brain by the hunger-signaling hormone ghrelin, researchers say. The finding points to a new potential target for the pharmacologic control of cholesterol levels.

The animal study, led by Matthias Tschp, MD, professor in the University of Cincinnati (UC) endocrinology division, appears online ahead of print Sunday, June 6, 2010, in Nature Neuroscience.

"We have long thought that cholesterol is exclusively regulated through dietary absorption or synthesis and secretion by the liver," says Tschp. "Our study shows for the first time that cholesterol is also under direct 'remote control' by specific neurocircuitry in the central nervous system."

The hormone ghrelin inhibits the melanocortin 4 receptor (MC4R) in the hypothalamus and is important for the regulation of food intake and energy expenditure. Tschp and his team found that increased levels of ghrelin in mice caused the animals to develop increased levels of blood-circulating cholesterol. This, the authors say, is due to a reduction in the uptake of cholesterol by the liver.

The research team next tested the effects of genetically deleting or chemically blocking MC4R in the central nervous system. This test also yielded increased levels of cholesterol, suggesting that MC4R was the central element of the "remote control."

"We were stunned to see that by switching MC4R off in the brain, we could even make injected cholesterol remain in the blood much longer," says Tschp, a researcher at UC's Metabolic Diseases Institute.

Cholesterol is a type of naturally occurring fat needed by the body, but too much cholesterol can lead to atherosclerosis, a buildup of plaque in the arteries. There are two types of cholesterol in humans―HDL (high-density lipoprotein) and LDL (low-density lipoprotein). LDL is considered the "bad" kind of cholesterol responsible for plaque buildup. HDL is the "good" kind that, in high levels, can prevent atherosclerosis.

Atherosclerosis can lead to heart attack. The American Heart Association estimates that a heart attack occurs every 34 seconds in the United States.

Due to the differences in the make-up of mice and human cholesterol, Tschp and his team say more work is needed before their studies could be directly applied to humans, but they say their finding adds to a growing body of evidence for the central nervous system's direct control over essential metabolic processes.


'/>"/>

Contact: Dama Kimmon
dama.kimmon@uc.edu
513-558-4519
University of Cincinnati Academic Health Center
Source:Eurekalert

Related biology news :

1. Using remote sensing to track invasive trees
2. Scientists report first remote, underwater detection of harmful algae, toxins
3. Robo-bats with metal muscles may be next generation of remote control flyers
4. Ultrasound shown to exert remote control of brain circuits
5. Remote technology sees through ice, snow and hot air to monitor power plants
6. Scientists use remote satellite imaging to predict outbreaks of infectious disease
7. Digital cameras, remote satellites measure crop water demand
8. Harlequin frog rediscovered in remote region of Colombia
9. Climates remote control on hurricanes
10. MIT: Remote-control nanoparticles deliver drugs directly into tumors
11. Parus Interactive Awarded Patent for Speech-Activated Remote System Management
Post Your Comments:
*Name:
*Comment:
*Email:
(Date:3/31/2016)... 2016  Genomics firm Nabsys has completed a financial ... Bready , M.D., who returned to the company in ... leadership team, including Chief Technology Officer, John Oliver ... Nurnberg and Vice President of Software and Informatics, ... Dr. Bready served as CEO of Nabsys from ...
(Date:3/22/2016)... 2016 According to ... for Consumer Industry by Type (Image, Motion, Pressure, ... & IT, Entertainment, Home Appliances, & Wearable ... 2022", published by MarketsandMarkets, the market for ... USD 26.76 Billion by 2022, at a ...
(Date:3/18/2016)... , March 18, 2016 --> ... of Biometrics, ICT, Manned & Unmanned Vehicles, Physical infrastructure and ... security companies in the border security market and the continuing ... and Europe has led visiongain to ... improved success. --> defence & security companies ...
Breaking Biology News(10 mins):
(Date:5/18/2016)... ... 2016 , ... STACS DNA Inc., the sample tracking software company, today announced ... kit processing to help them save time and reduce errors. , Sexual Assault kits ... processed and victims informed of results. Due to a previous lack of tools, many ...
(Date:5/17/2016)... , May 18, 2016 ... 2.0 prefilled pen following approval by EMA, the European ... leading science and technology company, the new pen version ... an increased level of confidence to patients during use. ... GONAL-f® prefilled pen easier to handle with a larger ...
(Date:5/17/2016)... ... May 17, 2016 , ... The Children’s Tumor Foundation ... monuments across the globe will show their support in the fight against neurofibromatosis (NF) ... NF, is a genetic disorder that causes tumors to grow on nerves throughout the ...
(Date:5/17/2016)... ... May 17, 2016 , ... HOLLOWAY AMERICA, a stainless steel pressure ... Tech Ed Day on Thursday, May 19 in St. Louis, Missouri. The event will ... will participate in a vendor showcase during the early afternoon of the event, where ...
Breaking Biology Technology: